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Journal Abstract Search

158 related items for PubMed ID: 34562469

  • 1. Breakdown of chemo-immune resistance by a TDO2-targeted Pt(IV) prodrug via attenuating endogenous Kyn-AhR-AQP4 metabolic circuity and TLS-promoted genomic instability.
    Chen F, Xu G, Tian W, Gou S.
    Biochem Pharmacol; 2021 Nov; 193():114785. PubMed ID: 34562469
    [Abstract] [Full Text] [Related]

  • 2. Targeting the IDO1/TDO2-KYN-AhR Pathway for Cancer Immunotherapy - Challenges and Opportunities.
    Cheong JE, Sun L.
    Trends Pharmacol Sci; 2018 Mar; 39(3):307-325. PubMed ID: 29254698
    [Abstract] [Full Text] [Related]

  • 3. Circumventing drug resistance through a CK2-targeted combination via attenuating endogenous AhR-TLS-promoted genomic instability in human colorectal cancer cells.
    Chen F, Wang Z, Wang Y, Gou S.
    Food Chem Toxicol; 2023 Jun; 176():113774. PubMed ID: 37037410
    [Abstract] [Full Text] [Related]

  • 4. Emerging JWA-targeted Pt(IV) prodrugs conjugated with CX-4945 to overcome chemo-immune-resistance.
    Chen F, Pei S, Wang X, Zhu Q, Gou S.
    Biochem Biophys Res Commun; 2020 Jan 15; 521(3):753-761. PubMed ID: 31703842
    [Abstract] [Full Text] [Related]

  • 5. Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner.
    Li F, Zhao Z, Zhang Z, Zhang Y, Guan W.
    BMC Cancer; 2021 Oct 17; 21(1):1112. PubMed ID: 34657603
    [Abstract] [Full Text] [Related]

  • 6. Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.
    Du L, Xing Z, Tao B, Li T, Yang D, Li W, Zheng Y, Kuang C, Yang Q.
    Signal Transduct Target Ther; 2020 Feb 21; 5(1):10. PubMed ID: 32296044
    [Abstract] [Full Text] [Related]

  • 7. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.
    D'Amato NC, Rogers TJ, Gordon MA, Greene LI, Cochrane DR, Spoelstra NS, Nemkov TG, D'Alessandro A, Hansen KC, Richer JK.
    Cancer Res; 2015 Nov 01; 75(21):4651-64. PubMed ID: 26363006
    [Abstract] [Full Text] [Related]

  • 8. Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-κB pathways.
    Chen F, Qin X, Xu G, Gou S, Jin X.
    Biochem Pharmacol; 2017 Jul 01; 135():50-68. PubMed ID: 28288821
    [Abstract] [Full Text] [Related]

  • 9. Targeting of neuroblastoma cells through Kynurenine-AHR pathway inhibition.
    Dos Santos IL, Mitchell M, Nogueira PAS, Lafita-Navarro MC, Perez-Castro L, Eriom J, Kilgore JA, Williams NS, Guo L, Xu L, Conacci-Sorrell M.
    FEBS J; 2024 May 01; 291(10):2172-2190. PubMed ID: 38431776
    [Abstract] [Full Text] [Related]

  • 10. TDO2 and tryptophan metabolites promote kynurenine/AhR signals to facilitate glioma progression and immunosuppression.
    Zhong C, Peng L, Tao B, Yin S, Lyu L, Ding H, Yang X, Peng T, He H, Zhou P.
    Am J Cancer Res; 2022 May 01; 12(6):2558-2575. PubMed ID: 35812057
    [Abstract] [Full Text] [Related]

  • 11. Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating AhR-TLS-promoted genomic instability in human colon cancer cells.
    Wang Z, Chen F, Wang Y, Gou S.
    Toxicol Appl Pharmacol; 2023 Sep 15; 475():116647. PubMed ID: 37543059
    [Abstract] [Full Text] [Related]

  • 12. Synergetic impact of combined navoximod with cisplatin mitigates chemo-immune resistance via blockading IDO1+ CAFs-secreted Kyn/AhR/IL-6 and pol ζ-prevented CIN in human oral squamous cell carcinoma.
    Chen F, Zhao D, Huang Y, Wen X, Feng S.
    Life Sci; 2023 Dec 15; 335():122239. PubMed ID: 37944638
    [Abstract] [Full Text] [Related]

  • 13. TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway.
    Zhao L, Wang B, Yang C, Lin Y, Zhang Z, Wang S, Ye Y, Shen Z.
    Gene; 2021 Aug 05; 792():145736. PubMed ID: 34051337
    [Abstract] [Full Text] [Related]

  • 14. Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer.
    Wu C, Spector SA, Theodoropoulos G, Nguyen DJM, Kim EY, Garcia A, Savaraj N, Lim DC, Paul A, Feun LG, Bickerdike M, Wangpaichitr M.
    Cancer Metab; 2023 May 24; 11(1):7. PubMed ID: 37226257
    [Abstract] [Full Text] [Related]

  • 15. TDO2 promotes bladder cancer progression via AhR-mediated SPARC/FILIP1L signaling.
    Ding X, Jin Y, Shi X, Wang Y, Jin Z, Yin L, Gao S, Lei Y, Yang J.
    Biochem Pharmacol; 2024 May 24; 223():116172. PubMed ID: 38552852
    [Abstract] [Full Text] [Related]

  • 16. TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway.
    Li L, Wang T, Li S, Chen Z, Wu J, Cao W, Wo Q, Qin X, Xu J.
    Front Oncol; 2020 May 24; 10():562823. PubMed ID: 33542896
    [Abstract] [Full Text] [Related]

  • 17. Constitutive TDO2 expression promotes liver cancer progression by an autocrine IL-6 signaling pathway.
    Wu Z, Yan L, Lin J, Ke K, Yang W.
    Cancer Cell Int; 2021 Oct 17; 21(1):538. PubMed ID: 34657635
    [Abstract] [Full Text] [Related]

  • 18. Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis.
    Hsu YL, Hung JY, Chiang SY, Jian SF, Wu CY, Lin YS, Tsai YM, Chou SH, Tsai MJ, Kuo PL.
    Oncotarget; 2016 May 10; 7(19):27584-98. PubMed ID: 27050278
    [Abstract] [Full Text] [Related]

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  • 20. Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor.
    Abuin-Martínez C, Vidal R, Gutiérrez-López MD, Pérez-Hernández M, Giménez-Gómez P, Morales-Puerto N, O'Shea E, Colado MI.
    Neuropharmacology; 2021 Apr 01; 187():108490. PubMed ID: 33607146
    [Abstract] [Full Text] [Related]

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