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121 related items for PubMed ID: 34664502

  • 1. Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid.
    Mellott DM, Torres D, Krieger IV, Cameron SA, Moghadamchargari Z, Laganowsky A, Sacchettini JC, Meek TD, Harris LD.
    J Am Chem Soc; 2021 Oct 27; 143(42):17666-17676. PubMed ID: 34664502
    [No Abstract] [Full Text] [Related]

  • 2. Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid.
    Pham TV, Mellott DM, Moghadamchargari Z, Chen K, Krieger I, Laganowsky A, Sacchettini JC, Meek TD.
    ACS Chem Biol; 2021 Mar 19; 16(3):463-470. PubMed ID: 33688722
    [Abstract] [Full Text] [Related]

  • 3. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
    Pham TV, Murkin AS, Moynihan MM, Harris L, Tyler PC, Shetty N, Sacchettini JC, Huang HL, Meek TD.
    Proc Natl Acad Sci U S A; 2017 Jul 18; 114(29):7617-7622. PubMed ID: 28679637
    [Abstract] [Full Text] [Related]

  • 4. The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.
    Ray S, Kreitler DF, Gulick AM, Murkin AS.
    ACS Chem Biol; 2018 Jun 15; 13(6):1470-1473. PubMed ID: 29782144
    [Abstract] [Full Text] [Related]

  • 5. Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate.
    Moynihan MM, Murkin AS.
    Biochemistry; 2014 Jan 14; 53(1):178-87. PubMed ID: 24354272
    [Abstract] [Full Text] [Related]

  • 6. Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
    Sharma V, Sharma S, Hoener zu Bentrup K, McKinney JD, Russell DG, Jacobs WR, Sacchettini JC.
    Nat Struct Biol; 2000 Aug 14; 7(8):663-8. PubMed ID: 10932251
    [Abstract] [Full Text] [Related]

  • 7. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence.
    Muñoz-Elías EJ, McKinney JD.
    Nat Med; 2005 Jun 14; 11(6):638-44. PubMed ID: 15895072
    [Abstract] [Full Text] [Related]

  • 8. Solvent isotope-induced equilibrium perturbation for isocitrate lyase.
    Quartararo CE, Hadi T, Cahill SM, Blanchard JS.
    Biochemistry; 2013 Dec 23; 52(51):9286-93. PubMed ID: 24261638
    [Abstract] [Full Text] [Related]

  • 9. Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism.
    Kwon S, Chun HL, Ha HJ, Lee SY, Park HH.
    PLoS One; 2021 Dec 23; 16(5):e0251067. PubMed ID: 33951112
    [Abstract] [Full Text] [Related]

  • 10. Advances in mycobacterial isocitrate lyase targeting and inhibitors.
    Krátký M, Vinšová J.
    Curr Med Chem; 2012 Dec 23; 19(36):6126-37. PubMed ID: 23092127
    [Abstract] [Full Text] [Related]

  • 11. Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor.
    Sriram D, Yogeeswari P, Methuku S, Vyas DR, Senthilkumar P, Alvala M, Jeankumar VU.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5149-54. PubMed ID: 21840711
    [Abstract] [Full Text] [Related]

  • 12. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.
    Gould TA, van de Langemheen H, Muñoz-Elías EJ, McKinney JD, Sacchettini JC.
    Mol Microbiol; 2006 Aug 15; 61(4):940-7. PubMed ID: 16879647
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of isocitrate lyase by 3-nitropropionate, a reaction-intermediate analogue.
    Schloss JV, Cleland WW.
    Biochemistry; 1982 Aug 31; 21(18):4420-7. PubMed ID: 7126549
    [No Abstract] [Full Text] [Related]

  • 14. Structure-based screening and molecular dynamics simulations offer novel natural compounds as potential inhibitors of Mycobacterium tuberculosis isocitrate lyase.
    Shukla R, Shukla H, Sonkar A, Pandey T, Tripathi T.
    J Biomol Struct Dyn; 2018 Jun 31; 36(8):2045-2057. PubMed ID: 28605994
    [Abstract] [Full Text] [Related]

  • 15. Regulation of the icl1 Gene Encoding the Major Isocitrate Lyase in Mycobacterium smegmatis.
    Ko EM, Kim JY, Lee S, Kim S, Hwang J, Oh JI.
    J Bacteriol; 2021 Nov 05; 203(23):e0040221. PubMed ID: 34516281
    [Abstract] [Full Text] [Related]

  • 16. Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis.
    Höner Zu Bentrup K, Miczak A, Swenson DL, Russell DG.
    J Bacteriol; 1999 Dec 05; 181(23):7161-7. PubMed ID: 10572116
    [Abstract] [Full Text] [Related]

  • 17. Identification of a novel inhibitor of isocitrate lyase as a potent antitubercular agent against both active and non-replicating Mycobacterium tuberculosis.
    Liu Y, Zhou S, Deng Q, Li X, Meng J, Guan Y, Li C, Xiao C.
    Tuberculosis (Edinb); 2016 Mar 05; 97():38-46. PubMed ID: 26980494
    [Abstract] [Full Text] [Related]

  • 18. Isocitrate lyase of Mycobacterium tuberculosis is inhibited by quercetin through binding at N-terminus.
    Shukla H, Kumar V, Singh AK, Rastogi S, Khan SR, Siddiqi MI, Krishnan MY, Akhtar MS.
    Int J Biol Macromol; 2015 Mar 05; 78():137-41. PubMed ID: 25869309
    [Abstract] [Full Text] [Related]

  • 19. Structure-function insights into elusive Mycobacterium tuberculosis protein Rv1916.
    Antil M, Sharma J, Brissonnet Y, Choudhary M, Gouin S, Gupta V.
    Int J Biol Macromol; 2019 Dec 01; 141():927-936. PubMed ID: 31505209
    [Abstract] [Full Text] [Related]

  • 20. Microbiology. A weak link in TB bacterium is found.
    Helmuth L.
    Science; 2000 Aug 18; 289(5482):1123-5. PubMed ID: 10970221
    [Abstract] [Full Text] [Related]

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