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185 related items for PubMed ID: 34743025

  • 1. Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR.
    Gährs M, Schrenk D.
    Toxicology; 2021 Dec; 464():153023. PubMed ID: 34743025
    [Abstract] [Full Text] [Related]

  • 2. Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes.
    Gährs M, Roos R, Andersson PL, Schrenk D.
    Toxicol Appl Pharmacol; 2013 Oct 01; 272(1):77-85. PubMed ID: 23770461
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of apoptosis in rat hepatocytes treated with 'non-dioxin-like' polychlorinated biphenyls.
    Bohnenberger S, Wagner B, Schmitz HJ, Schrenk D.
    Carcinogenesis; 2001 Oct 01; 22(10):1601-6. PubMed ID: 11576998
    [Abstract] [Full Text] [Related]

  • 4. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Toxicology; 2018 May 01; 400-401():20-27. PubMed ID: 29548889
    [Abstract] [Full Text] [Related]

  • 5. Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes.
    Li Z, Li L, Heyward S, Men S, Xu M, Sueyoshi T, Wang H.
    Cells; 2021 Dec 01; 10(12):. PubMed ID: 34943889
    [Abstract] [Full Text] [Related]

  • 6. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Xenobiotica; 2019 Feb 01; 49(2):227-238. PubMed ID: 29424600
    [Abstract] [Full Text] [Related]

  • 7. Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
    Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG.
    Toxicology; 2018 Mar 01; 396-397():23-32. PubMed ID: 29425889
    [Abstract] [Full Text] [Related]

  • 8. Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance.
    Goettel M, Werner C, Honarvar N, Gröters S, Fegert I, Haines C, Chatham LR, Vardy A, Lake BG.
    Toxicology; 2024 Jun 01; 505():153828. PubMed ID: 38740169
    [Abstract] [Full Text] [Related]

  • 9. Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
    Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.
    PLoS One; 2013 Jun 01; 8(4):e61802. PubMed ID: 23626729
    [Abstract] [Full Text] [Related]

  • 10. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
    Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.
    J Biol Chem; 2002 Jan 25; 277(4):2908-15. PubMed ID: 11706036
    [Abstract] [Full Text] [Related]

  • 11. Tumor promoters as inhibitors of apoptosis in rat hepatocytes.
    Schrenk D, Schmitz HJ, Bohnenberger S, Wagner B, Wörner W.
    Toxicol Lett; 2004 Apr 01; 149(1-3):43-50. PubMed ID: 15093247
    [Abstract] [Full Text] [Related]

  • 12. Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor.
    Wang Z, Li X, Wu Q, Lamb JC, Klaunig JE.
    J Appl Toxicol; 2017 Aug 01; 37(8):967-975. PubMed ID: 28218408
    [Abstract] [Full Text] [Related]

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  • 15. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner.
    Al-Salman F, Plant N.
    Toxicol Appl Pharmacol; 2012 Aug 15; 263(1):7-13. PubMed ID: 22664347
    [Abstract] [Full Text] [Related]

  • 16. The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.
    Shizu R, Ishimura M, Nobusawa S, Hosaka T, Sasaki T, Kakizaki S, Yoshinari K.
    Arch Toxicol; 2021 Mar 15; 95(3):1089-1102. PubMed ID: 33398415
    [Abstract] [Full Text] [Related]

  • 17. Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.
    Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M.
    Toxicol Sci; 2014 Aug 01; 140(2):259-70. PubMed ID: 24863967
    [Abstract] [Full Text] [Related]

  • 18. Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats.
    Goettel M, Fegert I, Honarvar N, Vardy A, Haines C, Chatham LR, Lake BG.
    Toxicology; 2020 Mar 30; 433-434():152394. PubMed ID: 32027962
    [Abstract] [Full Text] [Related]

  • 19. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
    Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG.
    Crit Rev Toxicol; 2014 Jan 30; 44(1):64-82. PubMed ID: 24180433
    [Abstract] [Full Text] [Related]

  • 20. Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance.
    Lake BG, Price RJ, Scott MP, Chatham LR, Vardy A, Osimitz TG.
    Toxicology; 2020 Jun 30; 439():152465. PubMed ID: 32320717
    [Abstract] [Full Text] [Related]

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