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169 related items for PubMed ID: 34781297

  • 1. Lentivirus-shRNA Mediated Prolyl Hydroxylase 2 Knockdown Increases HIF-1α and Inhibits Nucleus Pulposus Cells Degeneration.
    Chen Q, Shi F, Yang C, Mao G, Zhou C, Liu L, Yang X, Song Y.
    Cells Tissues Organs; 2023; 212(2):185-193. PubMed ID: 34781297
    [Abstract] [Full Text] [Related]

  • 2. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia.
    Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV.
    J Biol Chem; 2012 May 11; 287(20):16975-86. PubMed ID: 22451659
    [Abstract] [Full Text] [Related]

  • 3. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.
    Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV.
    J Biol Chem; 2015 Mar 13; 290(11):7195-207. PubMed ID: 25635047
    [Abstract] [Full Text] [Related]

  • 4. Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc.
    Schoepflin ZR, Shapiro IM, Risbud MV.
    J Bone Miner Res; 2016 Jun 13; 31(6):1287-99. PubMed ID: 26765925
    [Abstract] [Full Text] [Related]

  • 5. HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc.
    Fujita N, Chiba K, Shapiro IM, Risbud MV.
    J Bone Miner Res; 2012 Feb 13; 27(2):401-12. PubMed ID: 21987385
    [Abstract] [Full Text] [Related]

  • 6. PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study.
    Chen S, Fang XQ, Wang Q, Wang SW, Hu ZJ, Zhou ZJ, Xu WB, Wang JY, Qin A, Fan SW.
    Lab Invest; 2016 May 13; 96(5):561-9. PubMed ID: 26901836
    [Abstract] [Full Text] [Related]

  • 7. PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis.
    Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV.
    FASEB J; 2017 Sep 13; 31(9):3831-3847. PubMed ID: 28495754
    [Abstract] [Full Text] [Related]

  • 8. [Comparative study on biological characteristics between different generations of rabbit nucleus pulposus cells].
    Chen Q, Shi F, Yang X, Liu L, Song Y.
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2018 Jun 15; 32(6):660-667. PubMed ID: 29905041
    [Abstract] [Full Text] [Related]

  • 9. Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.
    Huang Y, Wang Y, Wu C, Tian W.
    Life Sci; 2019 Sep 01; 232():116565. PubMed ID: 31251999
    [Abstract] [Full Text] [Related]

  • 10. Hypoxia-inducible factor-lα mediates aggrecan and collagen Π expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration.
    Liu Z, Li C, Meng X, Bai Y, Qi J, Wang J, Zhou Q, Zhang W, Zhang X.
    Biochem Biophys Res Commun; 2017 Jul 01; 488(3):554-561. PubMed ID: 28526405
    [Abstract] [Full Text] [Related]

  • 11. Effects of hypoxia on differentiation from human placenta-derived mesenchymal stem cells to nucleus pulposus-like cells.
    Ni L, Liu X, Sochacki KR, Ebraheim M, Fahrenkopf M, Shi Q, Liu J, Yang H.
    Spine J; 2014 Oct 01; 14(10):2451-8. PubMed ID: 24662208
    [Abstract] [Full Text] [Related]

  • 12. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk.
    Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV.
    Am J Physiol Cell Physiol; 2007 Aug 01; 293(2):C621-31. PubMed ID: 17442734
    [Abstract] [Full Text] [Related]

  • 13. [Effect of Biantie pretreatment on serum level of PHD2/HIF-1α and brain tissue damage in rats during acute hypobaric hypoxia exposure].
    Li XY, Wu CH, Yan YJ, Wang DH, Wang MJ, Hou ZW.
    Zhongguo Zhen Jiu; 2022 Nov 12; 42(11):1278-84. PubMed ID: 36397226
    [Abstract] [Full Text] [Related]

  • 14. SHH-dependent knockout of HIF-1 alpha accelerates the degenerative process in mouse intervertebral disc.
    Wu WJ, Zhang XK, Zheng XF, Yang YH, Jiang SD, Jiang LS.
    Int J Immunopathol Pharmacol; 2013 Nov 12; 26(3):601-9. PubMed ID: 24067457
    [Abstract] [Full Text] [Related]

  • 15. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.
    Han WQ, Zhu Q, Hu J, Li PL, Zhang F, Li N.
    Biochim Biophys Acta; 2013 Jun 12; 1833(6):1454-62. PubMed ID: 23466866
    [Abstract] [Full Text] [Related]

  • 16. HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
    He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z.
    Autophagy; 2021 Nov 12; 17(11):3338-3360. PubMed ID: 33455530
    [Abstract] [Full Text] [Related]

  • 17. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.
    Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV.
    J Biol Chem; 2013 May 03; 288(18):12654-66. PubMed ID: 23530034
    [Abstract] [Full Text] [Related]

  • 18. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells.
    Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV.
    FASEB J; 2014 Jun 03; 28(6):2455-65. PubMed ID: 24558194
    [Abstract] [Full Text] [Related]

  • 19. [Effect of "nape seven needles" on expression of hypoxia inducible factor-1α and Notch1 in cervical intervertebral disc degeneration rats].
    Ding FF, Lu Y.
    Zhen Ci Yan Jiu; 2022 Oct 25; 47(10):872-7. PubMed ID: 36301163
    [Abstract] [Full Text] [Related]

  • 20. Activation of Hypoxia-Inducible Factor-1α Signaling Pathway Has the Protective Effect of Intervertebral Disc Degeneration.
    Kim JW, An HJ, Yeo H, Jeong Y, Lee H, Lee J, Nam K, Lee J, Shin DE, Lee S.
    Int J Mol Sci; 2021 Oct 21; 22(21):. PubMed ID: 34768786
    [Abstract] [Full Text] [Related]

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