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Journal Abstract Search

139 related items for PubMed ID: 34818997

  • 1. The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles.
    Teffera Y, Liu J, Krolikowski P, Zhao Z.
    Drug Metab Lett; 2021; 14(2):126-136. PubMed ID: 34818997
    [Abstract] [Full Text] [Related]

  • 2. In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
    Zhang JW, Deng HB, Zhang CY, Dai JQ, Li Q, Zheng QG, Wan HX, Yu HP, He F, Xu YC, Zhao S, Zhang JYJ.
    Eur J Drug Metab Pharmacokinet; 2019 Oct; 44(5):669-680. PubMed ID: 31030415
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  • 3. Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate.
    Li AC, Cui D, Yu E, Dobson K, Hellriegel ET, Robertson P.
    Xenobiotica; 2019 Mar; 49(3):302-312. PubMed ID: 29473769
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  • 4. Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase.
    Asano D, Shibayama T, Shiozawa H, Inoue SI, Shinozuka T, Murata S, Watanabe N, Yoshinari K.
    Xenobiotica; 2021 Sep; 51(9):1060-1070. PubMed ID: 34330191
    [Abstract] [Full Text] [Related]

  • 5. Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
    Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D.
    Drug Metab Dispos; 2023 Dec; 51(12):1591-1606. PubMed ID: 37751998
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  • 6. A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates.
    De Sousa Mendes M, L Orton A, Humphries HE, Jones B, Gardner I, Neuhoff S, Pilla Reddy V.
    Drug Metab Dispos; 2020 Nov; 48(11):1231-1238. PubMed ID: 32893186
    [Abstract] [Full Text] [Related]

  • 7. Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
    Strelevitz TJ, Orozco CC, Obach RS.
    Drug Metab Dispos; 2012 Jul; 40(7):1441-8. PubMed ID: 22522748
    [Abstract] [Full Text] [Related]

  • 8. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
    Hosogi J, Ohashi R, Maeda H, Tashiro S, Fuse E, Yamamoto Y, Kuwabara T.
    Drug Metab Pharmacokinet; 2017 Oct; 32(5):255-264. PubMed ID: 28751116
    [Abstract] [Full Text] [Related]

  • 9. The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
    Morrison RD, Blobaum AL, Byers FW, Santomango TS, Bridges TM, Stec D, Brewer KA, Sanchez-Ponce R, Corlew MM, Rush R, Felts AS, Manka J, Bates BS, Venable DF, Rodriguez AL, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2012 Sep; 40(9):1834-45. PubMed ID: 22711749
    [Abstract] [Full Text] [Related]

  • 10. The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition.
    Tang LWT, Shi Y, Sharma R, Obach RS.
    Drug Metab Dispos; 2024 Aug 14; 52(9):1020-1028. PubMed ID: 38889967
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  • 13. Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Crouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2016 Aug 14; 44(8):1296-303. PubMed ID: 26936972
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  • 17. Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.
    Inoue K, Mizuo H, Kawaguchi S, Fukuda K, Kusano K, Yoshimura T.
    Drug Metab Dispos; 2014 Aug 14; 42(8):1326-33. PubMed ID: 24914245
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  • 18. Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant).
    Crouch RD, Blobaum AL, Felts AS, Conn PJ, Lindsley CW.
    Drug Metab Dispos; 2017 Dec 14; 45(12):1245-1259. PubMed ID: 28939686
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  • 19. Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans.
    Akabane T, Tanaka K, Irie M, Terashita S, Teramura T.
    Xenobiotica; 2011 May 14; 41(5):372-84. PubMed ID: 21385103
    [Abstract] [Full Text] [Related]

  • 20. Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs.
    Subash S, Singh DK, Ahire DS, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Heyward S, Cronin CN, Prasad B.
    Drug Metab Dispos; 2023 Oct 14; 51(10):1362-1371. PubMed ID: 37429730
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