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199 related items for PubMed ID: 34943889

  • 1. Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes.
    Li Z, Li L, Heyward S, Men S, Xu M, Sueyoshi T, Wang H.
    Cells; 2021 Dec 01; 10(12):. PubMed ID: 34943889
    [Abstract] [Full Text] [Related]

  • 2. SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver.
    Li L, Li H, Garzel B, Yang H, Sueyoshi T, Li Q, Shu Y, Zhang J, Hu B, Heyward S, Moeller T, Xie W, Negishi M, Wang H.
    Mol Pharmacol; 2015 Apr 01; 87(4):674-82. PubMed ID: 25628225
    [Abstract] [Full Text] [Related]

  • 3. Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.
    Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H.
    Mol Pharmacol; 2019 Sep 01; 96(3):345-354. PubMed ID: 31436536
    [Abstract] [Full Text] [Related]

  • 4. Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
    Preiss LC, Liu R, Hewitt P, Thompson D, Georgi K, Badolo L, Lauschke VM, Petersson C.
    Drug Metab Dispos; 2021 Aug 01; 49(8):668-678. PubMed ID: 34035124
    [Abstract] [Full Text] [Related]

  • 5. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
    Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.
    J Biol Chem; 2002 Jan 25; 277(4):2908-15. PubMed ID: 11706036
    [Abstract] [Full Text] [Related]

  • 6. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Toxicology; 2018 May 01; 400-401():20-27. PubMed ID: 29548889
    [Abstract] [Full Text] [Related]

  • 7. Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR.
    Bell AW, Michalopoulos GK.
    Hepatology; 2006 Jul 01; 44(1):186-94. PubMed ID: 16799975
    [Abstract] [Full Text] [Related]

  • 8. Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.
    Tamasi V, Juvan P, Beer M, Rozman D, Meyer UA.
    Mol Pharm; 2009 Jul 01; 6(5):1573-81. PubMed ID: 19708687
    [Abstract] [Full Text] [Related]

  • 9. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
    Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.
    Toxicol Sci; 2014 Jun 01; 139(2):501-11. PubMed ID: 24690595
    [Abstract] [Full Text] [Related]

  • 10. Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
    Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.
    PLoS One; 2013 Jun 01; 8(4):e61802. PubMed ID: 23626729
    [Abstract] [Full Text] [Related]

  • 11. Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR.
    Gährs M, Schrenk D.
    Toxicology; 2021 Dec 01; 464():153023. PubMed ID: 34743025
    [Abstract] [Full Text] [Related]

  • 12. Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.
    de Boussac H, Gondeau C, Briolotti P, Duret C, Treindl F, Römer M, Fabre JM, Herrero A, Ramos J, Maurel P, Templin M, Gerbal-Chaloin S, Daujat-Chavanieu M.
    Drug Metab Dispos; 2018 Mar 01; 46(3):223-236. PubMed ID: 29269410
    [Abstract] [Full Text] [Related]

  • 13. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
    Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O.
    Drug Metab Dispos; 2006 Oct 01; 34(10):1756-63. PubMed ID: 16837569
    [Abstract] [Full Text] [Related]

  • 14. Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
    Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG.
    Toxicology; 2018 Mar 01; 396-397():23-32. PubMed ID: 29425889
    [Abstract] [Full Text] [Related]

  • 15. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
    Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA.
    Mol Pharmacol; 2008 Apr 01; 73(4):1282-9. PubMed ID: 18187584
    [Abstract] [Full Text] [Related]

  • 16. The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.
    Shizu R, Ishimura M, Nobusawa S, Hosaka T, Sasaki T, Kakizaki S, Yoshinari K.
    Arch Toxicol; 2021 Mar 01; 95(3):1089-1102. PubMed ID: 33398415
    [Abstract] [Full Text] [Related]

  • 17. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
    Krausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P.
    Biochem Pharmacol; 2011 Dec 01; 82(11):1771-80. PubMed ID: 21920351
    [Abstract] [Full Text] [Related]

  • 18. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation.
    Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W.
    Pharm Res; 2013 Sep 01; 30(9):2199-208. PubMed ID: 23896737
    [Abstract] [Full Text] [Related]

  • 19. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
    Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL.
    J Biol Chem; 2003 Apr 18; 278(16):14146-52. PubMed ID: 12571232
    [Abstract] [Full Text] [Related]

  • 20. Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.
    Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.
    Antimicrob Agents Chemother; 2013 Mar 18; 57(3):1332-8. PubMed ID: 23274663
    [Abstract] [Full Text] [Related]

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