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Journal Abstract Search

199 related items for PubMed ID: 34943889

  • 21. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Xenobiotica; 2019 Feb; 49(2):227-238. PubMed ID: 29424600
    [Abstract] [Full Text] [Related]

  • 22. Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins.
    Cuko L, Duniec-Dmuchowski Z, Rondini EA, Pant A, Fallon JK, Wilson EM, Peraino NJ, Westrick JA, Smith PC, Kocarek TA.
    Drug Metab Dispos; 2021 Aug; 49(8):706-717. PubMed ID: 34011532
    [Abstract] [Full Text] [Related]

  • 23. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.
    Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PR, Lehmler HJ, Negishi M, Birnbaum LS.
    Toxicol Sci; 2014 Feb; 137(2):292-302. PubMed ID: 24218150
    [Abstract] [Full Text] [Related]

  • 24. Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.
    Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M.
    Toxicol Sci; 2014 Aug 01; 140(2):259-70. PubMed ID: 24863967
    [Abstract] [Full Text] [Related]

  • 25. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
    Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG.
    Crit Rev Toxicol; 2014 Jan 01; 44(1):64-82. PubMed ID: 24180433
    [Abstract] [Full Text] [Related]

  • 26. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.
    Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O.
    Br J Pharmacol; 2012 Mar 01; 165(5):1595-608. PubMed ID: 21913896
    [Abstract] [Full Text] [Related]

  • 27. Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor.
    Wang Z, Li X, Wu Q, Lamb JC, Klaunig JE.
    J Appl Toxicol; 2017 Aug 01; 37(8):967-975. PubMed ID: 28218408
    [Abstract] [Full Text] [Related]

  • 28. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.
    Drug Metab Dispos; 2007 Jul 01; 35(7):1032-41. PubMed ID: 17392393
    [Abstract] [Full Text] [Related]

  • 29. An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.
    Li L, Sinz MW, Zimmermann K, Wang H.
    J Pharmacol Exp Ther; 2012 Mar 01; 340(3):688-97. PubMed ID: 22171088
    [Abstract] [Full Text] [Related]

  • 30. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.
    Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E.
    J Biol Chem; 2004 Jul 09; 279(28):29295-301. PubMed ID: 15123723
    [Abstract] [Full Text] [Related]

  • 31. The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes.
    Davidson BP, Dogra SC, May BK.
    Mol Pharmacol; 2001 Aug 09; 60(2):274-81. PubMed ID: 11455014
    [Abstract] [Full Text] [Related]

  • 32. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.
    Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.
    J Biochem Mol Toxicol; 2009 Aug 09; 23(1):43-58. PubMed ID: 19202563
    [Abstract] [Full Text] [Related]

  • 33. Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
    Hu Q, Yao N, Wu J, Liu M, Liu F, Zhang H, Xiong Y, Xia C.
    Biochem Pharmacol; 2019 Jan 09; 159():32-39. PubMed ID: 30414935
    [Abstract] [Full Text] [Related]

  • 34. Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes.
    Moscovitz JE, Kalgutkar AS, Nulick K, Johnson N, Lin Z, Goosen TC, Weng Y.
    J Pharmacol Exp Ther; 2018 May 09; 365(2):262-271. PubMed ID: 29440451
    [Abstract] [Full Text] [Related]

  • 35. Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.
    Li D, Mackowiak B, Brayman TG, Mitchell M, Zhang L, Huang SM, Wang H.
    Biochem Pharmacol; 2015 Nov 01; 98(1):190-202. PubMed ID: 26275810
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  • 36. Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.
    Watanabe K, Sakurai K, Tsuchiya Y, Yamazoe Y, Yoshinari K.
    Biochem Pharmacol; 2013 Aug 01; 86(3):428-36. PubMed ID: 23732298
    [Abstract] [Full Text] [Related]

  • 37. Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
    Yoshinari K, Shizu R.
    Drug Metab Dispos; 2022 Jul 01; 50(7):1019-1026. PubMed ID: 35184041
    [Abstract] [Full Text] [Related]

  • 38. Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.
    Li Y, Buckley D, Wang S, Klaassen CD, Zhong XB.
    Drug Metab Dispos; 2009 Sep 01; 37(9):1978-86. PubMed ID: 19541828
    [Abstract] [Full Text] [Related]

  • 39. Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.
    Roth A, Looser R, Kaufmann M, Meyer UA.
    Pharmacogenet Genomics; 2008 Apr 01; 18(4):325-37. PubMed ID: 18334917
    [Abstract] [Full Text] [Related]

  • 40. Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
    Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR.
    Toxicol Sci; 2010 Aug 01; 116(2):452-66. PubMed ID: 20403969
    [Abstract] [Full Text] [Related]

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