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167 related items for PubMed ID: 34959647

  • 1. Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening.
    Bobrovs R, Kanepe I, Narvaiss N, Patetko L, Kalnins G, Sisovs M, Bula AL, Grinberga S, Boroduskis M, Ramata-Stunda A, Rostoks N, Jirgensons A, Tars K, Jaudzems K.
    Pharmaceuticals (Basel); 2021 Nov 30; 14(12):. PubMed ID: 34959647
    [Abstract] [Full Text] [Related]

  • 2. A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases.
    Samrat SK, Bashir Q, Zhang R, Huang Y, Liu Y, Wu X, Brown T, Wang W, Zheng YG, Zhang QY, Chen Y, Li Z, Li H.
    Emerg Microbes Infect; 2023 Dec 30; 12(1):2204164. PubMed ID: 37060263
    [Abstract] [Full Text] [Related]

  • 3. Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
    Bobiļeva O, Bobrovs R, Kaņepe I, Patetko L, Kalniņš G, Šišovs M, Bula AL, Gri Nberga S, Borodušķis MR, Ramata-Stunda A, Rostoks N, Jirgensons A, Ta Rs K, Jaudzems K.
    ACS Med Chem Lett; 2021 Jul 08; 12(7):1102-1107. PubMed ID: 34257831
    [Abstract] [Full Text] [Related]

  • 4. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
    Ahmed-Belkacem R, Sutto-Ortiz P, Guiraud M, Canard B, Vasseur JJ, Decroly E, Debart F.
    Eur J Med Chem; 2020 Sep 01; 201():112557. PubMed ID: 32563813
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  • 6. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
    Klima M, Khalili Yazdi A, Li F, Chau I, Hajian T, Bolotokova A, Kaniskan HÜ, Han Y, Wang K, Li D, Luo M, Jin J, Boura E, Vedadi M.
    Protein Sci; 2022 Sep 01; 31(9):e4395. PubMed ID: 36040262
    [Abstract] [Full Text] [Related]

  • 7. Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19.
    Selvaraj C, Dinesh DC, Panwar U, Abhirami R, Boura E, Singh SK.
    J Biomol Struct Dyn; 2021 Aug 01; 39(13):4582-4593. PubMed ID: 32567979
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  • 10. Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
    Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M.
    SLAS Discov; 2021 Oct 01; 26(9):1200-1211. PubMed ID: 34192965
    [Abstract] [Full Text] [Related]

  • 11. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases.
    Hausdorff M, Delpal A, Barelier S, Nicollet L, Canard B, Touret F, Colmant A, Coutard B, Vasseur JJ, Decroly E, Debart F.
    Eur J Med Chem; 2023 Aug 05; 256():115474. PubMed ID: 37192550
    [Abstract] [Full Text] [Related]

  • 12. 3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors.
    Bobileva O, Bobrovs R, Sirma EE, Kanepe I, Bula AL, Patetko L, Ramata-Stunda A, Grinberga S, Jirgensons A, Jaudzems K.
    Molecules; 2023 Jan 12; 28(2):. PubMed ID: 36677825
    [Abstract] [Full Text] [Related]

  • 13. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.
    Ahmed-Belkacem R, Hausdorff M, Delpal A, Sutto-Ortiz P, Colmant AMG, Touret F, Ogando NS, Snijder EJ, Canard B, Coutard B, Vasseur JJ, Decroly E, Debart F.
    J Med Chem; 2022 Apr 28; 65(8):6231-6249. PubMed ID: 35439007
    [Abstract] [Full Text] [Related]

  • 14. Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
    Kottur J, White KM, Rodriguez ML, Rechkoblit O, Quintana-Feliciano R, Nayar A, García-Sastre A, Aggarwal AK.
    PLoS Pathog; 2023 Jul 28; 19(7):e1011546. PubMed ID: 37523415
    [Abstract] [Full Text] [Related]

  • 15. Computational Analysis of SAM Analogs as Methyltransferase Inhibitors of nsp16/nsp10 Complex from SARS-CoV-2.
    Balieiro AM, Anunciação ELS, Costa CHS, Qayed WS, Silva JRA.
    Int J Mol Sci; 2022 Nov 12; 23(22):. PubMed ID: 36430451
    [Abstract] [Full Text] [Related]

  • 16. Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16).
    Kumar M, Roy A, Rawat RS, Alok A, Tetala KKR, Biswas NR, Kaur P, Kumar S.
    J Biomol Struct Dyn; 2022 Nov 12; 40(24):13965-13975. PubMed ID: 34766876
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  • 17. Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10.
    Zhao H, Liu J, He L, Zhang L, Yu R, Kang C.
    Biochem Biophys Res Commun; 2022 Oct 20; 626():114-120. PubMed ID: 35988295
    [Abstract] [Full Text] [Related]

  • 18. In silico validation of coumarin derivatives as potential inhibitors against Main Protease, NSP10/NSP16-Methyltransferase, Phosphatase and Endoribonuclease of SARS CoV-2.
    Maurya AK, Mishra N.
    J Biomol Struct Dyn; 2021 Nov 20; 39(18):7306-7321. PubMed ID: 32835632
    [Abstract] [Full Text] [Related]

  • 19. Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
    Devkota K, Schapira M, Perveen S, Yazdi AK, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M.
    bioRxiv; 2021 Feb 19. PubMed ID: 33619486
    [Abstract] [Full Text] [Related]

  • 20. Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus.
    Jiang Y, Liu L, Manning M, Bonahoom M, Lotvola A, Yang Z, Yang ZQ.
    J Biomol Struct Dyn; 2022 Feb 19; 40(3):1331-1346. PubMed ID: 33016237
    [Abstract] [Full Text] [Related]

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