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165 related items for PubMed ID: 3496045

  • 1. Comparative toxicity and antioxidant activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its monoamine oxidase B-generated metabolites in isolated hepatocytes and liver microsomes.
    Ekström G, Di Monte D, Sandy MS, Smith MT.
    Arch Biochem Biophys; 1987 May 15; 255(1):14-8. PubMed ID: 3496045
    [Abstract] [Full Text] [Related]

  • 2. Role of 1-methyl-4-phenylpyridinium ion formation and accumulation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity to isolated hepatocytes.
    Di Monte D, Ekström G, Shinka T, Smith MT, Trevor AJ, Castagnoli N.
    Chem Biol Interact; 1987 May 15; 62(2):105-16. PubMed ID: 3496169
    [Abstract] [Full Text] [Related]

  • 3. Mutagenicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolites.
    Cashman JR.
    Toxicology; 1987 Feb 15; 43(2):173-82. PubMed ID: 2949395
    [Abstract] [Full Text] [Related]

  • 4. Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+.
    Wu E, Shinka T, Caldera-Munoz P, Yoshizumi H, Trevor A, Castagnoli N.
    Chem Res Toxicol; 1988 Feb 15; 1(3):186-94. PubMed ID: 2979730
    [Abstract] [Full Text] [Related]

  • 5. MPTP and MPTP analogs induced cell death in cultured rat hepatocytes involving the formation of pyridinium metabolites.
    Singh Y, Swanson E, Sokoloski E, Kutty RK, Krishna G.
    Toxicol Appl Pharmacol; 1988 Nov 15; 96(2):347-59. PubMed ID: 3143167
    [Abstract] [Full Text] [Related]

  • 6. Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.
    Heikkila RE, Nicklas WJ, Vyas I, Duvoisin RC.
    Neurosci Lett; 1985 Dec 18; 62(3):389-94. PubMed ID: 3912685
    [Abstract] [Full Text] [Related]

  • 7. Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Singer TP, Salach JI, Crabtree D.
    Biochem Biophys Res Commun; 1985 Mar 15; 127(2):707-12. PubMed ID: 3872126
    [Abstract] [Full Text] [Related]

  • 8. 1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium.
    Shi H, Noguchi N, Xu Y, Niki E.
    FEBS Lett; 1999 Nov 19; 461(3):196-200. PubMed ID: 10567696
    [Abstract] [Full Text] [Related]

  • 9. Comparative toxicity of MPTP, MPP+ and 3,3-dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigra.
    Sayre LM, Arora PK, Iacofano LA, Harik SI.
    Eur J Pharmacol; 1986 May 13; 124(1-2):171-4. PubMed ID: 3487462
    [Abstract] [Full Text] [Related]

  • 10. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
    Kass GE, Wright JM, Nicotera P, Orrenius S.
    Arch Biochem Biophys; 1988 Feb 01; 260(2):789-97. PubMed ID: 2963592
    [Abstract] [Full Text] [Related]

  • 11. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes.
    Di Monte D, Jewell SA, Ekström G, Sandy MS, Smith MT.
    Biochem Biophys Res Commun; 1986 May 29; 137(1):310-5. PubMed ID: 3487319
    [Abstract] [Full Text] [Related]

  • 12. Fructose prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced ATP depletion and toxicity in isolated hepatocytes.
    Di Monte D, Sandy MS, Blank L, Smith MT.
    Biochem Biophys Res Commun; 1988 Jun 16; 153(2):734-40. PubMed ID: 3260098
    [Abstract] [Full Text] [Related]

  • 13. MPTP, MPP+ and mitochondrial function.
    Nicklas WJ, Youngster SK, Kindt MV, Heikkila RE.
    Life Sci; 1987 Feb 23; 40(8):721-9. PubMed ID: 3100899
    [Abstract] [Full Text] [Related]

  • 14. Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Dramatic effect of beta-mercaptoethanol on substrate turnover and enzyme inactivation.
    Hiebert CK, Sayre LM, Silverman RB.
    J Biol Chem; 1989 Dec 25; 264(36):21516-21. PubMed ID: 2600079
    [Abstract] [Full Text] [Related]

  • 15. Bioactivation of MPTP: reactive metabolites and possible biochemical sequelae.
    Trevor AJ, Castagnoli N, Caldera P, Ramsay RR, Singer TP.
    Life Sci; 1987 Feb 23; 40(8):713-9. PubMed ID: 3492651
    [Abstract] [Full Text] [Related]

  • 16. Toxicity of the 1-methyl-4-phenyl-2,3-dihydropyridinium and 1-methyl-4-phenylpyridinium species in primary cultures of mouse astrocytes.
    Wu EY, Langston JW, Di Monte DA.
    J Pharmacol Exp Ther; 1992 Jul 23; 262(1):225-30. PubMed ID: 1625201
    [Abstract] [Full Text] [Related]

  • 17. Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases.
    Singer TP, Salach JI, Castagnoli N, Trevor A.
    Biochem J; 1986 May 01; 235(3):785-9. PubMed ID: 3489461
    [Abstract] [Full Text] [Related]

  • 18. Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Peterson LA, Caldera PS, Trevor A, Chiba K, Castagnoli N.
    J Med Chem; 1985 Oct 01; 28(10):1432-6. PubMed ID: 3876442
    [Abstract] [Full Text] [Related]

  • 19. Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates.
    Ríos C, Tapia R.
    Neurosci Lett; 1987 Jun 26; 77(3):321-6. PubMed ID: 3497366
    [Abstract] [Full Text] [Related]

  • 20. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Castagnoli N, Chiba K, Trevor AJ.
    Life Sci; 1985 Jan 21; 36(3):225-30. PubMed ID: 3871243
    [Abstract] [Full Text] [Related]

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