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Journal Abstract Search

181 related items for PubMed ID: 34974334

  • 1. Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse.
    Kido Y, Nanchi I, Fusamae Y, Matsuzaki T, Akazawa T, Sawada H, Iwasaki M, Nishida K, Tsuchiya E, Okuda T.
    Drug Metab Pharmacokinet; 2022 Feb; 42():100426. PubMed ID: 34974334
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  • 3. Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios.
    Sato S, Matsumiya K, Tohyama K, Kosugi Y.
    AAPS J; 2021 Jun 03; 23(4):81. PubMed ID: 34085128
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  • 4. Impact of P-Glycoprotein-Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates.
    Nagaya Y, Katayama K, Kusuhara H, Nozaki Y.
    Drug Metab Dispos; 2020 Nov 03; 48(11):1183-1190. PubMed ID: 32862147
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  • 7. Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model.
    Peng J, Ladumor MK, Unadkat JD.
    Drug Metab Dispos; 2022 May 03; 50(5):613-623. PubMed ID: 35149540
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  • 11. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
    Ye D, Harder A, Fang Z, Weinheimer M, Laplanche L, Mezler M.
    Pharm Res; 2020 Sep 11; 37(10):194. PubMed ID: 32918191
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  • 12. A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery.
    Huang L, Wells MC, Zhao Z.
    Drug Metab Lett; 2019 Sep 11; 13(2):78-94. PubMed ID: 30854983
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  • 13. Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
    Nagaya Y, Nozaki Y, Kobayashi K, Takenaka O, Nakatani Y, Kusano K, Yoshimura T, Kusuhara H.
    Drug Metab Pharmacokinet; 2014 Sep 11; 29(5):419-26. PubMed ID: 24806821
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  • 14. Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo.
    Zhang Y, Shipkova PA, Warrack BM, Nelson DM, Wang L, Huo R, Chen J, Panfen E, Chen XQ, Fancher RM, Ruan Q, Christopher LJ, Xue Y, Sinz M, Shen H.
    Drug Metab Dispos; 2023 Jul 11; 51(7):851-861. PubMed ID: 37055191
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