These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis. Yoshinari K. Biol Pharm Bull; 2019; 42(8):1243-1252. PubMed ID: 31366862 [Abstract] [Full Text] [Related]
6. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG. Toxicology; 2018 May 01; 400-401():20-27. PubMed ID: 29548889 [Abstract] [Full Text] [Related]
8. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. J Biol Chem; 2003 Apr 18; 278(16):14146-52. PubMed ID: 12571232 [Abstract] [Full Text] [Related]
15. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Crit Rev Toxicol; 2014 Jan 30; 44(1):64-82. PubMed ID: 24180433 [Abstract] [Full Text] [Related]
18. Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR. Tamasi V, Juvan P, Beer M, Rozman D, Meyer UA. Mol Pharm; 2009 Jan 30; 6(5):1573-81. PubMed ID: 19708687 [Abstract] [Full Text] [Related]