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158 related items for PubMed ID: 35408998

  • 1. A Pharmacokinetic and Metabolism Study of the TRPC6 Inhibitor SH045 in Mice by LC-MS/MS.
    Chai XN, Ludwig FA, Müglitz A, Gong Y, Schaefer M, Regenthal R, Krügel U.
    Int J Mol Sci; 2022 Mar 26; 23(7):. PubMed ID: 35408998
    [Abstract] [Full Text] [Related]

  • 2. Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl N-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice.
    Chai XN, Ludwig FA, Müglitz A, Schaefer M, Yin HY, Brust P, Regenthal R, Krügel U.
    Pharmaceuticals (Basel); 2021 Mar 13; 14(3):. PubMed ID: 33805686
    [Abstract] [Full Text] [Related]

  • 3. In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome.
    Zheng Z, Xu Y, Krügel U, Schaefer M, Grune T, Nürnberg B, Köhler MB, Gollasch M, Tsvetkov D, Markó L.
    Int J Mol Sci; 2022 Jun 20; 23(12):. PubMed ID: 35743312
    [Abstract] [Full Text] [Related]

  • 4. A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6.
    Häfner S, Burg F, Kannler M, Urban N, Mayer P, Dietrich A, Trauner D, Broichhagen J, Schaefer M.
    ChemMedChem; 2018 May 23; 13(10):1028-1035. PubMed ID: 29522264
    [Abstract] [Full Text] [Related]

  • 5. Role of TRPC6 in kidney damage after acute ischemic kidney injury.
    Zheng Z, Tsvetkov D, Bartolomaeus TUP, Erdogan C, Krügel U, Schleifenbaum J, Schaefer M, Nürnberg B, Chai X, Ludwig FA, N'diaye G, Köhler MB, Wu K, Gollasch M, Markó L.
    Sci Rep; 2022 Feb 22; 12(1):3038. PubMed ID: 35194063
    [Abstract] [Full Text] [Related]

  • 6. Pharmacokinetics, bioavailability and tissue distribution study of JCC-02, a novel N-methyl-d-aspartate (NMDA) receptor inhibitor, in rats by LC-MS/MS.
    Yang T, Shi Y, Lin C, Yan C, Zhang D, Lin J.
    Eur J Pharm Sci; 2019 Apr 01; 131():146-152. PubMed ID: 30776467
    [Abstract] [Full Text] [Related]

  • 7. Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).
    Motoyama K, Nagata T, Kobayashi J, Nakamura A, Miyoshi N, Kazui M, Sakurai K, Sakakura T.
    Bioorg Med Chem Lett; 2018 Jul 01; 28(12):2222-2227. PubMed ID: 29752182
    [Abstract] [Full Text] [Related]

  • 8. Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol.
    Urban N, Neuser S, Hentschel A, Köhling S, Rademann J, Schaefer M.
    Br J Pharmacol; 2017 Nov 01; 174(22):4099-4122. PubMed ID: 28800680
    [Abstract] [Full Text] [Related]

  • 9. Atractylodis rhizoma water extract attenuates fructose-induced glomerular injury in rats through anti-oxidation to inhibit TRPC6/p-CaMK4 signaling.
    Chen L, Yang J, Zhao SJ, Li TS, Jiao RQ, Kong LD.
    Phytomedicine; 2021 Oct 01; 91():153643. PubMed ID: 34325092
    [Abstract] [Full Text] [Related]

  • 10. Determination of myrislignan levels in BALB/c mouse plasma by LC-MS/MS and a comparison of its pharmacokinetics after oral and intraperitoneal administration.
    Zhang J, Si H, Sun J, Lv K, Yan B, Li B, Zhou X, Zhang J.
    BMC Vet Res; 2021 Aug 16; 17(1):275. PubMed ID: 34399756
    [Abstract] [Full Text] [Related]

  • 11. Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.
    Mooiman KD, Maas-Bakker RF, Rosing H, Beijnen JH, Schellens JH, Meijerman I.
    Biomed Chromatogr; 2013 Sep 16; 27(9):1107-16. PubMed ID: 23674377
    [Abstract] [Full Text] [Related]

  • 12. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov 16; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 13. Preclinical comprehensive physicochemical and pharmacokinetic profiling of novel nitroimidazole derivative IIIM-019 - A potential oral treatment for tuberculosis.
    Kour G, Kumar A, Singh PP, Sharma S, Bhagat A, Vishwakarma RA, Ahmed Z.
    Pulm Pharmacol Ther; 2016 Oct 16; 40():44-51. PubMed ID: 27457685
    [Abstract] [Full Text] [Related]

  • 14. Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn , and LC-HR-MS/MS.
    Caspar AT, Gaab JB, Michely JA, Brandt SD, Meyer MR, Maurer HH.
    Drug Test Anal; 2018 Jan 16; 10(1):184-195. PubMed ID: 28342193
    [Abstract] [Full Text] [Related]

  • 15. Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics.
    Jayaraman R, Pilla Reddy V, Pasha MK, Wang H, Sangthongpitag K, Yeo P, Hu CY, Wu X, Xin L, Goh E, New LS, Ethirajulu K.
    Drug Metab Dispos; 2011 Dec 16; 39(12):2219-32. PubMed ID: 21873472
    [Abstract] [Full Text] [Related]

  • 16. Development and validation of LC-MS/MS method for quantification of novel PP2A - β-catenin signalling inhibitor, S011-2111 in mice plasma: Application to its preclinical pharmacokinetic studies.
    Riyazuddin M, Husain A, Valicherla GR, Verma S, Gupta AP, Praveena KS, Singh A, Avula SR, Sashidhara KV, Datta D, Gayen JR.
    J Chromatogr B Analyt Technol Biomed Life Sci; 2019 Nov 01; 1130-1131():121829. PubMed ID: 31670104
    [Abstract] [Full Text] [Related]

  • 17. Pharmacokinetics of single-dose and multiple-dose memantine in healthy chinese volunteers using an analytic method of liquid chromatography-tandem mass spectrometry.
    Liu MY, Meng SN, Wu HZ, Wang S, Wei MJ.
    Clin Ther; 2008 Apr 01; 30(4):641-53. PubMed ID: 18498913
    [Abstract] [Full Text] [Related]

  • 18. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats.
    Egorin MJ, Lagattuta TF, Hamburger DR, Covey JM, White KD, Musser SM, Eiseman JL.
    Cancer Chemother Pharmacol; 2002 Jan 01; 49(1):7-19. PubMed ID: 11855755
    [Abstract] [Full Text] [Related]

  • 19. Determination of l-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic study.
    Moreira LN, Feltrin C, Gonçalves JE, de Castro WV, Simões CMO, de Pádua RM, Cortes SF, Braga FC.
    Biomed Pharmacother; 2020 Dec 01; 132():110900. PubMed ID: 33113433
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  • 20. Pharmacokinetics, plasma protein binding, and metabolism of a potential natural chemosensitizer from Marsdenia tenacissima in rats.
    Xie B, Jiang SQ, Shen XL, Wu HQ, Hu YJ.
    J Ethnopharmacol; 2021 Dec 05; 281():114544. PubMed ID: 34419608
    [Abstract] [Full Text] [Related]

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