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Journal Abstract Search

195 related items for PubMed ID: 35499073

  • 1. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1.
    Lee WS, Al-Ramahi I, Jeong HH, Jang Y, Lin T, Adamski CJ, Lavery LA, Rath S, Richman R, Bondar VV, Alcala E, Revelli JP, Orr HT, Liu Z, Botas J, Zoghbi HY.
    J Clin Invest; 2022 May 02; 132(9):. PubMed ID: 35499073
    [Abstract] [Full Text] [Related]

  • 2. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
    Nitschke L, Coffin SL, Xhako E, El-Najjar DB, Orengo JP, Alcala E, Dai Y, Wan YW, Liu Z, Orr HT, Zoghbi HY.
    JCI Insight; 2021 Feb 08; 6(3):. PubMed ID: 33554954
    [Abstract] [Full Text] [Related]

  • 3. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
    Lee WS, Lavery L, Rousseaux MWC, Rutledge EB, Jang Y, Wan YW, Wu SR, Kim W, Al-Ramahi I, Rath S, Adamski CJ, Bondar VV, Tewari A, Soleimani S, Mota S, Yalamanchili HK, Orr HT, Liu Z, Botas J, Zoghbi HY.
    EMBO J; 2021 Apr 01; 40(7):e106106. PubMed ID: 33709453
    [Abstract] [Full Text] [Related]

  • 4. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.
    Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G.
    Neuroscience; 2016 Jul 07; 327():20-31. PubMed ID: 27058144
    [Abstract] [Full Text] [Related]

  • 5. Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
    Handler HP, Duvick L, Mitchell JS, Cvetanovic M, Reighard M, Soles A, Mather KB, Rainwater O, Serres S, Nichols-Meade T, Coffin SL, You Y, Ruis BL, O'Callaghan B, Henzler C, Zoghbi HY, Orr HT.
    Neuron; 2023 Feb 15; 111(4):493-507.e6. PubMed ID: 36577403
    [Abstract] [Full Text] [Related]

  • 6. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
    Rousseaux MWC, Tschumperlin T, Lu HC, Lackey EP, Bondar VV, Wan YW, Tan Q, Adamski CJ, Friedrich J, Twaroski K, Chen W, Tolar J, Henzler C, Sharma A, Bajić A, Lin T, Duvick L, Liu Z, Sillitoe RV, Zoghbi HY, Orr HT.
    Neuron; 2018 Mar 21; 97(6):1235-1243.e5. PubMed ID: 29526553
    [Abstract] [Full Text] [Related]

  • 7. PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.
    Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY.
    Hum Mol Genet; 2018 Aug 15; 27(16):2863-2873. PubMed ID: 29860311
    [Abstract] [Full Text] [Related]

  • 8. Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models.
    Asher M, Rosa JG, Rainwater O, Duvick L, Bennyworth M, Lai RY, CRC-SCA, Kuo SH, Cvetanovic M.
    Hum Mol Genet; 2020 Jan 01; 29(1):117-131. PubMed ID: 31696233
    [Abstract] [Full Text] [Related]

  • 9. Ataxin-1 regulates proliferation of hippocampal neural precursors.
    Asher M, Johnson A, Zecevic B, Pease D, Cvetanovic M.
    Neuroscience; 2016 May 13; 322():54-65. PubMed ID: 26876606
    [Abstract] [Full Text] [Related]

  • 10. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
    Orr HT.
    Prog Neurobiol; 2012 Dec 13; 99(3):179-85. PubMed ID: 22531670
    [Abstract] [Full Text] [Related]

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  • 12. Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1.
    Shuvaev AN, Belozor OS, Mozhei OI, Shuvaev AN, Fritsler YV, Khilazheva ED, Mosyagina AI, Hirai H, Teschemacher AG, Kasparov S.
    Cells; 2022 Jul 20; 11(14):. PubMed ID: 35883691
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  • 14. ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms.
    Rocha S, Vieira J, Vázquez N, López-Fernández H, Fdez-Riverola F, Reboiro-Jato M, Sousa AD, Vieira CP.
    BMC Med Genomics; 2019 Oct 26; 12(1):145. PubMed ID: 31655597
    [Abstract] [Full Text] [Related]

  • 15. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
    Crespo-Barreto J, Fryer JD, Shaw CA, Orr HT, Zoghbi HY.
    PLoS Genet; 2010 Jul 08; 6(7):e1001021. PubMed ID: 20628574
    [Abstract] [Full Text] [Related]

  • 16. BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1.
    Rosa JG, Hamel K, Soles A, Sheeler C, Borgenheimer E, Gilliat S, Sbrocco K, Ghanoum F, Handler HP, Forster C, Rainwater O, Cvetanovic M.
    Neurobiol Dis; 2023 Mar 08; 178():106023. PubMed ID: 36724861
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  • 19. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
    Bowman AB, Lam YC, Jafar-Nejad P, Chen HK, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY.
    Nat Genet; 2007 Mar 08; 39(3):373-9. PubMed ID: 17322884
    [Abstract] [Full Text] [Related]

  • 20. Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model.
    Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJ.
    Cerebellum; 2014 Oct 08; 13(5):596-606. PubMed ID: 24930030
    [Abstract] [Full Text] [Related]

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