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134 related items for PubMed ID: 35803175

  • 1. Design and synthesis of NAD(P)H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties.
    Zhu H, Lu L, Zhu W, Tan Y, Duan Y, Liu J, Ye W, Zhu Z, Xu J, Xu S.
    Eur J Med Chem; 2022 Oct 05; 240():114575. PubMed ID: 35803175
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.
    Xu S, Yao H, Pei L, Hu M, Li D, Qiu Y, Wang G, Wu L, Yao H, Zhu Z, Xu J.
    Eur J Med Chem; 2017 May 26; 132():310-321. PubMed ID: 28395199
    [Abstract] [Full Text] [Related]

  • 3. An NAD(P)H:Quinone Oxidoreductase 1 Responsive and Self-Immolative Prodrug of 5-Fluorouracil for Safe and Effective Cancer Therapy.
    Zhang X, Li X, Li Z, Wu X, Wu Y, You Q, Zhang X.
    Org Lett; 2018 Jun 15; 20(12):3635-3638. PubMed ID: 29847952
    [Abstract] [Full Text] [Related]

  • 4. 3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.
    Jaffar M, Phillips RM, Williams KJ, Mrema I, Cole C, Wind NS, Ward TH, Stratford IJ, Patterson AV.
    Biochem Pharmacol; 2003 Oct 01; 66(7):1199-206. PubMed ID: 14505799
    [Abstract] [Full Text] [Related]

  • 5. Isopentyl-Deoxynboquinone Induces Mitochondrial Dysfunction and G2/M Phase Cell Cycle Arrest to Selectively Kill NQO1-Positive Pancreatic Cancer Cells.
    Jiang L, Liu Y, Tumbath S, Boudreau MW, Chatkewitz LE, Wang J, Su X, Zahid KR, Li K, Chen Y, Yang K, Hergenrother PJ, Huang X.
    Antioxid Redox Signal; 2024 Jul 01; 41(1-3):74-92. PubMed ID: 37950707
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents.
    Qu Y, Zhang C, Ma X, Gao Y, Liu J, Wu L.
    Bioorg Med Chem; 2020 Dec 15; 28(24):115821. PubMed ID: 33091789
    [Abstract] [Full Text] [Related]

  • 7. Synthesis, biological evaluation and mechanism studies of C-3 substituted nitrogenous heterocyclic 23-Hydroxybetulinic acid derivatives as anticancer agents.
    Zhou H, Zhu H, Zha Y, Xu J, Wang T, Xu S.
    Fitoterapia; 2022 Jul 15; 160():105222. PubMed ID: 35618147
    [Abstract] [Full Text] [Related]

  • 8. Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.
    Volpato M, Abou-Zeid N, Tanner RW, Glassbrook LT, Taylor J, Stratford I, Loadman PM, Jaffar M, Phillips RM.
    Mol Cancer Ther; 2007 Dec 15; 6(12 Pt 1):3122-30. PubMed ID: 18089707
    [Abstract] [Full Text] [Related]

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  • 10. Novel β-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage.
    Guo Y, Xu L, Ling C, Yang T, Zheng W, Lv J, Guo Q, Chen B.
    Chem Biol Drug Des; 2020 Dec 15; 96(6):1433-1446. PubMed ID: 32592323
    [Abstract] [Full Text] [Related]

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  • 12. NQO1-selective activated prodrugs of combretastatin A-4: Synthesis and biological evaluation.
    Zhang C, Qu Y, Ma X, Li M, Li S, Li Y, Wu L.
    Bioorg Chem; 2020 Oct 15; 103():104200. PubMed ID: 32890998
    [Abstract] [Full Text] [Related]

  • 13. Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
    Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA.
    Clin Cancer Res; 2005 Apr 15; 11(8):3055-64. PubMed ID: 15837761
    [Abstract] [Full Text] [Related]

  • 14. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
    Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D.
    Biochem Pharmacol; 2001 Jun 15; 61(12):1509-16. PubMed ID: 11377380
    [Abstract] [Full Text] [Related]

  • 15. An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
    Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA.
    Cancer Res; 2012 Jun 15; 72(12):3038-47. PubMed ID: 22532167
    [Abstract] [Full Text] [Related]

  • 16. Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.
    Swann E, Barraja P, Oberlander AM, Gardipee WT, Hudnott AR, Beall HD, Moody CJ.
    J Med Chem; 2001 Sep 27; 44(20):3311-9. PubMed ID: 11563930
    [Abstract] [Full Text] [Related]

  • 17. Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities.
    Ling Y, Yang QX, Teng YN, Chen S, Gao WJ, Guo J, Hsu PL, Liu Y, Morris-Natschke SL, Hung CC, Lee KH.
    Eur J Med Chem; 2018 Jun 25; 154():199-209. PubMed ID: 29803003
    [Abstract] [Full Text] [Related]

  • 18. Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer.
    Wu X, Li X, Li Z, Yu Y, You Q, Zhang X.
    J Med Chem; 2018 Dec 27; 61(24):11280-11297. PubMed ID: 30508483
    [Abstract] [Full Text] [Related]

  • 19. Effect of β-Eudesmol on NQO1 suppression-enhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents.
    Srijiwangsa P, Ponnikorn S, Na-Bangchang K.
    BMC Pharmacol Toxicol; 2018 Jun 19; 19(1):32. PubMed ID: 29914576
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and biological activity of 1,4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate.
    Kadela-Tomanek M, Jastrzębska M, Marciniec K, Chrobak E, Bębenek E, Latocha M, Kuśmierz D, Boryczka S.
    Bioorg Chem; 2021 Jan 19; 106():104478. PubMed ID: 33272711
    [Abstract] [Full Text] [Related]

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