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229 related items for PubMed ID: 3599032

  • 1. Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
    Nair MG, Dhawan R, Ghazala M, Kalman TI, Ferone R, Gaumont Y, Kisliuk RL.
    J Med Chem; 1987 Jul; 30(7):1256-61. PubMed ID: 3599032
    [Abstract] [Full Text] [Related]

  • 2. Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
    Nair MG, Nanavati NT, Nair IG, Kisliuk RL, Gaumont Y, Hsiao MC, Kalman TI.
    J Med Chem; 1986 Sep; 29(9):1754-60. PubMed ID: 3091832
    [Abstract] [Full Text] [Related]

  • 3. Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.
    Patil SD, Jones C, Nair MG, Galivan J, Maley F, Kisliuk RL, Gaumont Y, Duch D, Ferone R.
    J Med Chem; 1989 Jun; 32(6):1284-9. PubMed ID: 2542557
    [Abstract] [Full Text] [Related]

  • 4. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Kimbell R, Gibson W, Boyle FT, Bisset GM.
    J Med Chem; 1996 Jan 05; 39(1):73-85. PubMed ID: 8568829
    [Abstract] [Full Text] [Related]

  • 5. Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.
    Jones TR, Smithers MJ, Taylor MA, Jackman AL, Calvert AH, Harland SJ, Harrap KR.
    J Med Chem; 1986 Apr 05; 29(4):468-72. PubMed ID: 3754284
    [Abstract] [Full Text] [Related]

  • 6. Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.
    Thornton TJ, Jones TR, Jackman AL, Flinn A, O'Connor BM, Warner P, Calvert AH.
    J Med Chem; 1991 Mar 05; 34(3):978-84. PubMed ID: 2002476
    [Abstract] [Full Text] [Related]

  • 7. Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.
    Li SW, Nair MG, Edwards DM, Kisliuk RL, Gaumont Y, Dev IK, Duch DS, Humphreys J, Smith GK, Ferone R.
    J Med Chem; 1991 Sep 05; 34(9):2746-54. PubMed ID: 1895294
    [Abstract] [Full Text] [Related]

  • 8. Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.
    Ghazala M, Nair MG, Toghiyani TR, Kisliuk RL, Gaumont Y, Kalman TI.
    J Med Chem; 1986 Jul 05; 29(7):1263-9. PubMed ID: 3100797
    [Abstract] [Full Text] [Related]

  • 9. Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid.
    Nair MG, Salter DC, Kisliuk RL, Gaumont Y, North G, Sirotnak FM.
    J Med Chem; 1983 Apr 05; 26(4):605-7. PubMed ID: 6403710
    [Abstract] [Full Text] [Related]

  • 10. Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
    Jackman AL, Marsham PR, Thornton TJ, Bishop JA, O'Connor BM, Hughes LR, Calvert AH, Jones TR.
    J Med Chem; 1990 Nov 05; 33(11):3067-71. PubMed ID: 2231607
    [Abstract] [Full Text] [Related]

  • 11. Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid.
    Jones TR, Smithers MJ, Betteridge RF, Taylor MA, Jackman AL, Calvert AH, Davies LC, Harrap KR.
    J Med Chem; 1986 Jun 05; 29(6):1114-8. PubMed ID: 3712376
    [Abstract] [Full Text] [Related]

  • 12. Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
    Thornton TJ, Jackman AL, Marsham PR, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1992 Jun 12; 35(12):2321-7. PubMed ID: 1613755
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
    Piper JR, Malik ND, Rhee MS, Galivan J, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):332-7. PubMed ID: 1732551
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  • 16. Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Thornton TJ, Pawelczak K, Boyle FT, Bisset GM.
    Adv Exp Med Biol; 1993 Jan 24; 338():593-6. PubMed ID: 8304188
    [No Abstract] [Full Text] [Related]

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  • 18. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Jackman AL, Alison DL, Calvert AH, Harrap KR.
    Cancer Res; 1986 Jun 24; 46(6):2810-5. PubMed ID: 2938731
    [Abstract] [Full Text] [Related]

  • 19. Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
    Marsham PR, Jackman AL, Barker AJ, Boyle FT, Pegg SJ, Wardleworth JM, Kimbell R, O'Connor BM, Calvert AH, Hughes LR.
    J Med Chem; 1995 Mar 17; 38(6):994-1004. PubMed ID: 7699716
    [Abstract] [Full Text] [Related]

  • 20. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
    [Abstract] [Full Text] [Related]

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