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132 related items for PubMed ID: 36007604

  • 1. IKs inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog.
    van Bavel JJA, Beekman HDM, van Weperen VYH, van der Linde HJ, van der Heyden MAG, Vos MA.
    Eur J Pharmacol; 2022 Oct 15; 932():175218. PubMed ID: 36007604
    [Abstract] [Full Text] [Related]

  • 2. Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model.
    Varkevisser R, van der Heyden MA, Tieland RG, Beekman JD, Vos MA.
    Eur J Pharmacol; 2013 Nov 15; 720(1-3):49-54. PubMed ID: 24211677
    [Abstract] [Full Text] [Related]

  • 3. IKs Activator ML277 Mildly Affects Repolarization and Arrhythmic Outcome in the CAVB Dog Model.
    van Bavel JJA, Beekman HDM, Smoczyńska A, van der Heyden MAG, Vos MA.
    Biomedicines; 2023 Apr 11; 11(4):. PubMed ID: 37189765
    [Abstract] [Full Text] [Related]

  • 4. Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog.
    Dunnink A, van Opstal JM, Oosterhoff P, Winckels SK, Beekman JD, van der Nagel R, Cora Verduyn S, Vos MA.
    Europace; 2012 Mar 11; 14(3):431-6. PubMed ID: 21946817
    [Abstract] [Full Text] [Related]

  • 5. The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs.
    Stams TR, Bourgonje VJ, Beekman HD, Schoenmakers M, van der Nagel R, Oosterhoff P, van Opstal JM, Vos MA.
    Br J Pharmacol; 2014 Feb 11; 171(3):714-22. PubMed ID: 24490860
    [Abstract] [Full Text] [Related]

  • 6. Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs.
    Bossu A, Kostense A, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA.
    Pharmacol Res; 2018 Jul 11; 133():132-140. PubMed ID: 29753687
    [Abstract] [Full Text] [Related]

  • 7. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
    Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA.
    Br J Pharmacol; 2018 Jun 11; 175(12):2470-2482. PubMed ID: 29582428
    [Abstract] [Full Text] [Related]

  • 8. Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
    Antoons G, Oros A, Beekman JD, Engelen MA, Houtman MJ, Belardinelli L, Stengl M, Vos MA.
    J Am Coll Cardiol; 2010 Feb 23; 55(8):801-9. PubMed ID: 20170820
    [Abstract] [Full Text] [Related]

  • 9. Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model.
    Dunnink A, Sharif S, Oosterhoff P, Winckels S, Montagne D, Beekman J, van der Nagel R, van der Heyden MA, Vos MA.
    J Cardiovasc Pharmacol; 2010 Jun 23; 55(6):601-8. PubMed ID: 20555233
    [Abstract] [Full Text] [Related]

  • 10. Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.
    Stams TR, Oosterhoff P, Heijdel A, Dunnink A, Beekman JD, van der Nagel R, van Rijen HV, van der Heyden MA, Vos MA.
    Circ J; 2016 May 25; 80(6):1336-45. PubMed ID: 27151565
    [Abstract] [Full Text] [Related]

  • 11. LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
    Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG.
    Br J Pharmacol; 2019 Oct 25; 176(19):3871-3885. PubMed ID: 31339551
    [Abstract] [Full Text] [Related]

  • 12. Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome.
    van Opstal JM, Schoenmakers M, Verduyn SC, de Groot SH, Leunissen JD, van Der Hulst FF, Molenschot MM, Wellens HJ, Vos MA.
    Circulation; 2001 Nov 27; 104(22):2722-7. PubMed ID: 11723026
    [Abstract] [Full Text] [Related]

  • 13. Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias.
    Van Opstal JM, Leunissen JD, Wellens HJ, Vos MA.
    Eur J Pharmacol; 2001 Jan 19; 412(1):67-76. PubMed ID: 11166738
    [Abstract] [Full Text] [Related]

  • 14. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011 Jan 19; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

  • 15. Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes.
    Stams TR, Oros A, der Nagel Rv, Beekman JD, Chamberlin P, Dittrich HC, Vos MA.
    Eur J Pharmacol; 2011 Dec 15; 672(1-3):126-34. PubMed ID: 22001562
    [Abstract] [Full Text] [Related]

  • 16. An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog.
    Sprenkeler DJ, Bossu A, Beekman JDM, Schoenmakers M, Vos MA.
    Front Physiol; 2018 Dec 15; 9():1086. PubMed ID: 30135660
    [Abstract] [Full Text] [Related]

  • 17. Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
    Boulaksil M, Jungschleger JG, Antoons G, Houtman MJ, de Boer TP, Wilders R, Beekman JD, Maessen JG, van der Hulst FF, van der Heyden MA, van Veen TA, van Rijen HV, de Bakker JM, Vos MA.
    Circ Arrhythm Electrophysiol; 2011 Aug 15; 4(4):566-76. PubMed ID: 21622813
    [Abstract] [Full Text] [Related]

  • 18. New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts.
    Kui P, Orosz S, Takács H, Sarusi A, Csík N, Rárosi F, Csekő C, Varró A, Papp JG, Forster T, Farkas AS, Farkas A.
    J Pharmacol Toxicol Methods; 2016 Aug 15; 80():26-34. PubMed ID: 27063345
    [Abstract] [Full Text] [Related]

  • 19. Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.
    Lengyel C, Varró A, Tábori K, Papp JG, Baczkó I.
    Br J Pharmacol; 2007 Aug 15; 151(7):941-51. PubMed ID: 17533421
    [Abstract] [Full Text] [Related]

  • 20. MS-551 and KCB-328, two class III drugs aggravated adrenaline-induced arrhythmias.
    Xue Y, Yamada C, Aye NN, Hashimoto K.
    Br J Pharmacol; 1998 Aug 15; 124(8):1712-8. PubMed ID: 9756388
    [Abstract] [Full Text] [Related]

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