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Journal Abstract Search

595 related items for PubMed ID: 36166898

  • 1. Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities.
    Ahmed AHH, Mohamed MFA, Allam RM, Nafady A, Mohamed SK, Gouda AE, Beshr EAM.
    Bioorg Chem; 2022 Dec; 129():106171. PubMed ID: 36166898
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and aromatase inhibitors with dual anti-inflammatory and anti-neoplastic activities.
    A A Fadaly W, A M M Elshaier Y, T M Nemr M, R A Abdellatif K.
    Bioorg Chem; 2023 May; 134():106428. PubMed ID: 36893546
    [Abstract] [Full Text] [Related]

  • 3. Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
    Shaker AMM, Shahin MI, AboulMagd AM, Abdel Aleem SA, Abdel-Rahman HM, Abou El Ella DA.
    Bioorg Chem; 2022 Dec; 129():106143. PubMed ID: 36191430
    [Abstract] [Full Text] [Related]

  • 4. New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.
    Fadaly WAA, Elshaier YAMM, Hassanein EHM, Abdellatif KRA.
    Bioorg Chem; 2020 May; 98():103752. PubMed ID: 32197148
    [Abstract] [Full Text] [Related]

  • 5. Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.
    Alswah M, Bayoumi AH, Elgamal K, Elmorsy A, Ihmaid S, Ahmed HEA.
    Molecules; 2017 Dec 27; 23(1):. PubMed ID: 29280968
    [Abstract] [Full Text] [Related]

  • 6. Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity.
    Mourad AAE, Mourad MAE, Jones PG.
    Drug Des Devel Ther; 2020 Dec 27; 14():3111-3130. PubMed ID: 32848361
    [Abstract] [Full Text] [Related]

  • 7. Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity.
    Shawky AM, Almalki FA, Abdalla AN, Youssif BGM, Abdel-Fattah MM, Hersi F, El-Sherief HAM, Ibrahim NA, Gouda AM.
    Eur J Med Chem; 2023 Nov 05; 259():115712. PubMed ID: 37567059
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors.
    Rahimzadeh Oskuei S, Mirzaei S, Reza Jafari-Nik M, Hadizadeh F, Eisvand F, Mosaffa F, Ghodsi R.
    Bioorg Chem; 2021 Jul 05; 112():104904. PubMed ID: 33933802
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition.
    Amin MM, Abuo-Rahma GEA, Shaykoon MSA, Marzouk AA, Abourehab MAS, Saraya RE, Badr M, Sayed AM, Beshr EAM.
    Bioorg Chem; 2023 May 05; 134():106444. PubMed ID: 36893547
    [Abstract] [Full Text] [Related]

  • 10. Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.
    Wang G, Liu W, Gong Z, Huang Y, Li Y, Peng Z.
    J Enzyme Inhib Med Chem; 2020 Dec 05; 35(1):139-144. PubMed ID: 31724435
    [Abstract] [Full Text] [Related]

  • 11. Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance.
    Liu Z, Yang Z, Ablise M.
    Bioorg Chem; 2024 Jun 05; 147():107310. PubMed ID: 38583249
    [Abstract] [Full Text] [Related]

  • 12. 1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity.
    Naaz F, Preeti Pallavi MC, Shafi S, Mulakayala N, Shahar Yar M, Sampath Kumar HM.
    Bioorg Chem; 2018 Dec 05; 81():1-20. PubMed ID: 30081353
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors.
    Wang YT, Shi TQ, Zhu HL, Liu CH.
    Bioorg Med Chem; 2019 Feb 01; 27(3):502-515. PubMed ID: 30606674
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors.
    Wang G, Liu W, Gong Z, Huang Y, Li Y, Peng Z.
    Bioorg Chem; 2020 Jan 01; 95():103565. PubMed ID: 31927336
    [Abstract] [Full Text] [Related]

  • 15. Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities.
    Fadaly WAA, Nemr MTM, Kahk NM.
    Bioorg Chem; 2024 Jun 01; 147():107403. PubMed ID: 38691909
    [Abstract] [Full Text] [Related]

  • 16. Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors.
    Wang G, Peng Z, Li Y.
    Chem Pharm Bull (Tokyo); 2019 Jul 01; 67(7):725-728. PubMed ID: 30982797
    [Abstract] [Full Text] [Related]

  • 17. Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
    Ghanim AM, Rezq S, Ibrahim TS, Romero DG, Kothayer H.
    Eur J Med Chem; 2021 Jul 05; 219():113457. PubMed ID: 33892270
    [Abstract] [Full Text] [Related]

  • 18. Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers.
    Sherbiny FF, Bayoumi AH, El-Morsy AM, Sobhy M, Hagras M.
    Bioorg Chem; 2021 Nov 05; 116():105325. PubMed ID: 34507234
    [Abstract] [Full Text] [Related]

  • 19. Synthesis of different heterocycles-linked chalcone conjugates as cytotoxic agents and tubulin polymerization inhibitors.
    Shankaraiah N, Nekkanti S, Brahma UR, Praveen Kumar N, Deshpande N, Prasanna D, Senwar KR, Jaya Lakshmi U.
    Bioorg Med Chem; 2017 Sep 01; 25(17):4805-4816. PubMed ID: 28774575
    [Abstract] [Full Text] [Related]

  • 20. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
    Shen FQ, Wang ZC, Wu SY, Ren SZ, Man RJ, Wang BZ, Zhu HL.
    Bioorg Med Chem Lett; 2017 Aug 15; 27(16):3653-3660. PubMed ID: 28720504
    [Abstract] [Full Text] [Related]

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