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Journal Abstract Search

225 related items for PubMed ID: 36435355

  • 1. Discovery of potent microtubule-destabilizing agents targeting for colchicine site by virtual screening, biological evaluation, and molecular dynamics simulation.
    Zhang H, Luo QQ, Hu ML, Wang N, Qi HZ, Zhang HR, Ding L.
    Eur J Pharm Sci; 2023 Jan 01; 180():106340. PubMed ID: 36435355
    [Abstract] [Full Text] [Related]

  • 2. Discovery of microtubule stabilizers with novel scaffold structures based on virtual screening, biological evaluation, and molecular dynamics simulation.
    Mao J, Luo QQ, Zhang HR, Zheng XH, Shen C, Qi HZ, Hu ML, Zhang H.
    Chem Biol Interact; 2022 Jan 25; 352():109784. PubMed ID: 34932952
    [Abstract] [Full Text] [Related]

  • 3. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.
    Prota AE, Danel F, Bachmann F, Bargsten K, Buey RM, Pohlmann J, Reinelt S, Lane H, Steinmetz MO.
    J Mol Biol; 2014 Apr 17; 426(8):1848-60. PubMed ID: 24530796
    [Abstract] [Full Text] [Related]

  • 4. In Silico Exploration of Novel Tubulin Inhibitors: A Combination of Docking and Molecular Dynamics Simulations, Pharmacophore Modeling, and Virtual Screening.
    Hadizadeh F, Ghodsi R, Mirzaei S, Sahebkar A.
    Comput Math Methods Med; 2022 Apr 17; 2022():4004068. PubMed ID: 35075369
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel microtubule stabilizers targeting taxane binding site by applying molecular docking, molecular dynamics simulation, and anticancer activity testing.
    Zhang H, Qi HZ, Mao J, Zhang HR, Luo QQ, Hu ML, Shen C, Ding L.
    Bioorg Chem; 2022 May 17; 122():105722. PubMed ID: 35303622
    [Abstract] [Full Text] [Related]

  • 6. Identification of Essential 2D and 3D Chemical Features for Discovery of the Novel Tubulin Polymerization Inhibitors.
    Azimi F, Ghasemi JB, Saghaei L, Hassanzadeh F, Mahdavi M, Sadeghi-Aliabadi H, Scotti MT, Scotti L.
    Curr Top Med Chem; 2019 May 17; 19(13):1092-1120. PubMed ID: 31109275
    [Abstract] [Full Text] [Related]

  • 7. Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin.
    Sun K, Sun Z, Zhao F, Shan G, Meng Q.
    Future Med Chem; 2021 May 17; 13(9):839-858. PubMed ID: 33821673
    [Abstract] [Full Text] [Related]

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  • 9. Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.
    Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz JF, Steinmetz MO.
    Int J Mol Sci; 2017 Jun 22; 18(7):. PubMed ID: 28640209
    [Abstract] [Full Text] [Related]

  • 10. Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.
    Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.
    Bioorg Chem; 2018 Dec 22; 81():553-566. PubMed ID: 30248507
    [Abstract] [Full Text] [Related]

  • 11. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
    Du T, Lin S, Ji M, Xue N, Liu Y, Zhang Z, Zhang K, Zhang J, Zhang Y, Wang Q, Sheng L, Li Y, Lu D, Chen X, Xu H.
    Cancer Lett; 2020 Dec 28; 495():22-32. PubMed ID: 32931884
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities.
    Sun YX, Song J, Kong LJ, Sha BB, Tian XY, Liu XJ, Hu T, Chen P, Zhang SY.
    Eur J Med Chem; 2022 Feb 05; 229():114069. PubMed ID: 34971875
    [Abstract] [Full Text] [Related]

  • 13. Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment.
    Guo Q, Zhang H, Deng Y, Zhai S, Jiang Z, Zhu D, Wang L.
    Eur J Med Chem; 2020 Jun 15; 196():112328. PubMed ID: 32320841
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors.
    Wang Z, Liu R, Zhang X, Chang X, Gao M, Zhang S, Guan Q, Sun J, Zuo D, Zhang W.
    Bioorg Med Chem; 2022 Mar 15; 58():116671. PubMed ID: 35193066
    [Abstract] [Full Text] [Related]

  • 15. Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations.
    Liu G, Jiao Y, Huang C, Chang P.
    J Comput Aided Mol Des; 2019 Jul 15; 33(7):659-664. PubMed ID: 31165955
    [Abstract] [Full Text] [Related]

  • 16. Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway.
    Song J, Wang SH, Song CH, Zhang WX, Zhu JX, Tian XY, Fu XJ, Xu Y, Jin CY, Zhang SY.
    Eur J Med Chem; 2022 Oct 05; 240():114583. PubMed ID: 35834904
    [Abstract] [Full Text] [Related]

  • 17. Discovery of novel tubulin inhibitors targeting taxanes site by virtual screening, molecular dynamic simulation, and biological evaluation.
    Zhang H, Mao J, Yang YL, Liu CT, Shen C, Zhang HR, Xie HZ, Ding L.
    J Cell Biochem; 2021 Nov 05; 122(11):1609-1624. PubMed ID: 34237164
    [Abstract] [Full Text] [Related]

  • 18. Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
    Cheng B, Zhu G, Meng L, Wu G, Chen Q, Ma S.
    Eur J Med Chem; 2022 Jan 15; 228():113930. PubMed ID: 34794817
    [Abstract] [Full Text] [Related]

  • 19. Identification of novel αβ-tubulin modulators with antiproliferative activity directed to cancer therapy using ligand and structure-based virtual screening.
    Federico LB, Silva GM, de Fraga Dias A, Figueiró F, Battastini AMO, Dos Santos CBR, Costa LT, Rosa JMC, de Paula da Silva CHT.
    Int J Biol Macromol; 2020 Dec 15; 165(Pt B):3040-3050. PubMed ID: 33736292
    [Abstract] [Full Text] [Related]

  • 20. The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site.
    Boichuk S, Galembikova A, Syuzov K, Dunaev P, Bikinieva F, Aukhadieva A, Zykova S, Igidov N, Gankova K, Novikova M, Kopnin P.
    Molecules; 2021 Sep 24; 26(19):. PubMed ID: 34641324
    [Abstract] [Full Text] [Related]

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