These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

191 related items for PubMed ID: 36633273

  • 1. Capturing the free energy of transition state stabilization: insights from the inhibition of mandelate racemase.
    Bearne SL.
    Philos Trans R Soc Lond B Biol Sci; 2023 Feb 27; 378(1871):20220041. PubMed ID: 36633273
    [Abstract] [Full Text] [Related]

  • 2. A Phenylboronic Acid-Based Transition State Analogue Yields Nanomolar Inhibition of Mandelate Racemase.
    Kuehm OP, Hayden JA, Bearne SL.
    Biochemistry; 2023 Jun 20; 62(12):1929-1942. PubMed ID: 37285384
    [Abstract] [Full Text] [Related]

  • 3. An additional role for the Brønsted acid-base catalysts of mandelate racemase in transition state stabilization.
    Nagar M, Bearne SL.
    Biochemistry; 2015 Nov 10; 54(44):6743-52. PubMed ID: 26480244
    [Abstract] [Full Text] [Related]

  • 4. Hydrophobic nature of the active site of mandelate racemase.
    St Maurice M, Bearne SL.
    Biochemistry; 2004 Mar 09; 43(9):2524-32. PubMed ID: 14992589
    [Abstract] [Full Text] [Related]

  • 5. Reaction intermediate analogues for mandelate racemase: interaction between Asn 197 and the alpha-hydroxyl of the substrate promotes catalysis.
    St Maurice M, Bearne SL.
    Biochemistry; 2000 Nov 07; 39(44):13324-35. PubMed ID: 11063568
    [Abstract] [Full Text] [Related]

  • 6. A Paradigm for CH Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase.
    Bearne SL, St Maurice M.
    Adv Protein Chem Struct Biol; 2017 Nov 07; 109():113-160. PubMed ID: 28683916
    [Abstract] [Full Text] [Related]

  • 7. Structure of mandelate racemase with bound intermediate analogues benzohydroxamate and cupferron.
    Lietzan AD, Nagar M, Pellmann EA, Bourque JR, Bearne SL, St Maurice M.
    Biochemistry; 2012 Feb 14; 51(6):1160-70. PubMed ID: 22264153
    [Abstract] [Full Text] [Related]

  • 8. Redefining the minimal substrate tolerance of mandelate racemase. Racemization of trifluorolactate.
    Nagar M, Narmandakh A, Khalak Y, Bearne SL.
    Biochemistry; 2011 Oct 18; 50(41):8846-52. PubMed ID: 21894901
    [Abstract] [Full Text] [Related]

  • 9. Kinetics and thermodynamics of mandelate racemase catalysis.
    St Maurice M, Bearne SL.
    Biochemistry; 2002 Mar 26; 41(12):4048-58. PubMed ID: 11900548
    [Abstract] [Full Text] [Related]

  • 10. Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center.
    Sharma AN, Grandinetti L, Johnson ER, St Maurice M, Bearne SL.
    Biochemistry; 2020 Aug 25; 59(33):3026-3037. PubMed ID: 32786399
    [Abstract] [Full Text] [Related]

  • 11. Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant.
    Kallarakal AT, Mitra B, Kozarich JW, Gerlt JA, Clifton JG, Petsko GA, Kenyon GL.
    Biochemistry; 1995 Mar 07; 34(9):2788-97. PubMed ID: 7893690
    [Abstract] [Full Text] [Related]

  • 12. Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis.
    Siddiqi F, Bourque JR, Jiang H, Gardner M, St Maurice M, Blouin C, Bearne SL.
    Biochemistry; 2005 Jun 28; 44(25):9013-21. PubMed ID: 15966725
    [Abstract] [Full Text] [Related]

  • 13. Potent inhibition of mandelate racemase by a fluorinated substrate-product analogue with a novel binding mode.
    Nagar M, Lietzan AD, St Maurice M, Bearne SL.
    Biochemistry; 2014 Feb 25; 53(7):1169-78. PubMed ID: 24472022
    [Abstract] [Full Text] [Related]

  • 14. The role of residue S139 of mandelate racemase: synergistic effect of S139 and E317 on transition state stabilization.
    Gu J, Yu H.
    J Biomol Struct Dyn; 2012 Feb 25; 30(5):585-93. PubMed ID: 22731931
    [Abstract] [Full Text] [Related]

  • 15. Altering the Y137-K164-K166 triad of mandelate racemase and its effect on the observed pKa of the Brønsted base catalysts.
    Fetter CM, Morrison ZA, Nagar M, Douglas CD, Bearne SL.
    Arch Biochem Biophys; 2019 May 15; 666():116-126. PubMed ID: 30935886
    [Abstract] [Full Text] [Related]

  • 16. Mandelate racemase in pieces: effective concentrations of enzyme functional groups in the transition state.
    Bearne SL, Wolfenden R.
    Biochemistry; 1997 Feb 18; 36(7):1646-56. PubMed ID: 9048548
    [Abstract] [Full Text] [Related]

  • 17. [Genome mining and characterization of a new mandelate racemase].
    Zhou M, Tang C, Xu J, Yu H.
    Sheng Wu Gong Cheng Xue Bao; 2018 Jun 25; 34(6):897-905. PubMed ID: 29943535
    [Abstract] [Full Text] [Related]

  • 18. Application of circular dichroism-based assays to racemases and epimerases: Recognition and catalysis of reactions of chiral substrates by mandelate racemase.
    Bearne SL, Hayden JA.
    Methods Enzymol; 2023 Jun 25; 685():127-169. PubMed ID: 37245900
    [Abstract] [Full Text] [Related]

  • 19. Virtual screening of mandelate racemase mutants with enhanced activity based on binding energy in the transition state.
    Gu J, Liu M, Guo F, Xie W, Lu W, Ye L, Chen Z, Yuan S, Yu H.
    Enzyme Microb Technol; 2014 Feb 05; 55():121-7. PubMed ID: 24411454
    [Abstract] [Full Text] [Related]

  • 20. Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317.
    Mitra B, Kallarakal AT, Kozarich JW, Gerlt JA, Clifton JG, Petsko GA, Kenyon GL.
    Biochemistry; 1995 Mar 07; 34(9):2777-87. PubMed ID: 7893689
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 10.