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104 related items for PubMed ID: 3668862

  • 1. Stereoselective glutathione conjugation and amidase-catalyzed hydrolysis of alpha-bromoisovalerylurea enantiomers in isolated rat hepatocytes.
    te Koppele JM, de Lannoy IA, Pang KS, Mulder GJ.
    J Pharmacol Exp Ther; 1987 Oct; 243(1):349-55. PubMed ID: 3668862
    [Abstract] [Full Text] [Related]

  • 2. Stereoselectivity in glutathione conjugation and amidase-catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single-pass perfused rat liver.
    Polhuijs M, Gasinska I, Cherry WF, Mulder GJ, Pang KS.
    J Pharmacol Exp Ther; 1993 Jun; 265(3):1406-12. PubMed ID: 8510017
    [Abstract] [Full Text] [Related]

  • 3. alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.
    te Koppele JM, Dogterom P, Vermeulen NP, Meijer DK, van der Gen A, Mulder GJ.
    J Pharmacol Exp Ther; 1986 Dec; 239(3):905-14. PubMed ID: 3795049
    [Abstract] [Full Text] [Related]

  • 4. Stereoselective glutathione conjugation of the separate alpha-bromoisovalerylurea and alpha-bromoisovaleric acid enantiomers in the rat in vivo and in rat liver subcellular fractions.
    te Koppele JM, Esajas SW, Brussee J, van der Gen A, Mulder GJ.
    Biochem Pharmacol; 1988 Jan 01; 37(1):29-35. PubMed ID: 3337736
    [Abstract] [Full Text] [Related]

  • 5. Stereoselectivity of glutathione conjugation: blood elimination of alpha-bromoisovalerylurea enantiomers and biliary excretion of the conjugates in unanesthetized normal or congenitally jaundiced rats.
    Polhuijs M, Kuipers F, Vonk RJ, Mulder GJ.
    J Pharmacol Exp Ther; 1989 Jun 01; 249(3):874-8. PubMed ID: 2732949
    [Abstract] [Full Text] [Related]

  • 6. alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. I. (Bio-) synthesis, analysis and identification of diastereomeric glutathione conjugates and mercapturates.
    te Koppele JM, van der Mark EJ, Olde Boerrigter JC, Brussee J, van der Gen A, van der Greef J, Mulder GJ.
    J Pharmacol Exp Ther; 1986 Dec 01; 239(3):898-904. PubMed ID: 3795048
    [Abstract] [Full Text] [Related]

  • 7. Isoenzyme-selective inhibition of glutathione conjugation in vivo: selective inhibition of the conjugation of S-2-Bromoisovalerylurea in the rat.
    Ouwerkerk-Mahadevan S, van Boom JH, Mulder GJ.
    J Pharmacol Exp Ther; 1996 Mar 01; 276(3):923-8. PubMed ID: 8786571
    [Abstract] [Full Text] [Related]

  • 8. Stereoselectivity of rat liver glutathione transferase isoenzymes for alpha-bromoisovaleric acid and alpha-bromoisovalerylurea enantiomers.
    Te Koppele JM, Coles B, Ketterer B, Mulder GJ.
    Biochem J; 1988 May 15; 252(1):137-42. PubMed ID: 3421896
    [Abstract] [Full Text] [Related]

  • 9. Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers.
    Mulders TM, van Ommen B, van Bladeren PJ, Breimer DD, Mulder GJ.
    Biochem Pharmacol; 1993 Nov 17; 46(10):1775-80. PubMed ID: 8250963
    [Abstract] [Full Text] [Related]

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  • 11. Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine.
    Ouwerkerk-Mahadevan S, Tirona RG, Ripping RA, Ploemen JH, van Bladeren PJ, Pang KS, van Boom JH, Mulder GJ.
    Drug Metab Dispos; 1997 Oct 17; 25(10):1137-43. PubMed ID: 9321516
    [Abstract] [Full Text] [Related]

  • 12. Stereospecific glutathione conjugation of (R)- and (S)-2-bromoisovalerylurea in freshly isolated rat kidney proximal tubular cells.
    Viver MM, Nagelkerke JF, Mulder GJ.
    Biochem Pharmacol; 1992 Feb 18; 43(4):902-4. PubMed ID: 1540244
    [Abstract] [Full Text] [Related]

  • 13. Relationship between glutathione content in liver and glutathione conjugation rate in the rat in vivo. Effect of buthionine sulphoximine pretreatment on conjugation of the two 2-bromoisovalerylurea enantiomers during intravenous infusion.
    Polhuijs M, Lankhaar G, Mulder GJ.
    Biochem J; 1992 Jul 15; 285 ( Pt 2)(Pt 2):401-4. PubMed ID: 1637334
    [Abstract] [Full Text] [Related]

  • 14. Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes.
    Cmarik JL, Inskeep PB, Meredith MJ, Meyer DJ, Ketterer B, Guengerich FP.
    Cancer Res; 1990 May 01; 50(9):2747-52. PubMed ID: 2328501
    [Abstract] [Full Text] [Related]

  • 15. Glutathione conjugation and pharmacokinetics of 2-bromo-3-phenylpropionic acid in vitro and in the rat in vivo.
    Snel CA, Mahadevan S, Polhuijs M, Mulder GJ.
    Chirality; 1992 May 01; 4(7):407-14. PubMed ID: 1361150
    [Abstract] [Full Text] [Related]

  • 16. Bimolecular glutathione conjugation kinetics of ethacrynic acid in rat liver: in vitro and perfusion studies.
    Tirona RG, Pang KS.
    J Pharmacol Exp Ther; 1999 Sep 01; 290(3):1230-41. PubMed ID: 10454499
    [Abstract] [Full Text] [Related]

  • 17. Stereoselectivity in the urinary excretion of the mercapturates of (R-) and (S-) alpha-bromoisovalerylurea in man.
    te Koppele JM, Schipper C, Breimer DD, Mulder GJ.
    Br J Clin Pharmacol; 1989 Aug 01; 28(2):151-4. PubMed ID: 2775620
    [Abstract] [Full Text] [Related]

  • 18. Stereoselectivity of glutathione conjugation in vivo, in the perfused liver and in isolated hepatocytes.
    Mulder GJ, te Koppele JM, Schipper CG, Snel WH, Pang KS, Polhuijs M.
    Drug Metab Rev; 1991 Aug 01; 23(3-4):311-30. PubMed ID: 1935574
    [No Abstract] [Full Text] [Related]

  • 19. Stereo- and regioselective conjugation of S-halovinyl mercapturic acid sulfoxides by glutathione S-transferases.
    Rosner E, Müller M, Dekant W.
    Chem Res Toxicol; 1998 Jan 01; 11(1):12-8. PubMed ID: 9477221
    [Abstract] [Full Text] [Related]

  • 20. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
    Tang W, Borel AG, Abbott FS.
    Drug Metab Dispos; 1996 Apr 01; 24(4):436-46. PubMed ID: 8801059
    [Abstract] [Full Text] [Related]

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