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176 related items for PubMed ID: 36861094

  • 1. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.
    Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S.
    Cancer Res Commun; 2022 Dec; 2(12):1711-1726. PubMed ID: 36861094
    [Abstract] [Full Text] [Related]

  • 2. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
    Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S.
    Mol Cancer Ther; 2017 May; 16(5):805-818. PubMed ID: 28450422
    [Abstract] [Full Text] [Related]

  • 3. Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models.
    Torres-Sanchez A, Rivera-Robles M, Castillo-Pichardo L, Martínez-Ferrer M, Dorta-Estremera SM, Dharmawardhane S.
    Front Oncol; 2023 May; 13():1152458. PubMed ID: 37397366
    [Abstract] [Full Text] [Related]

  • 4. Development of EHop-016: a small molecule inhibitor of Rac.
    Dharmawardhane S, Hernandez E, Vlaar C.
    Enzymes; 2013 May; 33 Pt A(Pt A):117-46. PubMed ID: 25033803
    [Abstract] [Full Text] [Related]

  • 5. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
    Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S.
    J Biol Chem; 2012 Apr 13; 287(16):13228-38. PubMed ID: 22383527
    [Abstract] [Full Text] [Related]

  • 6. Efficacy and delivery strategies of the dual Rac/Cdc42 inhibitor MBQ-167 in HER2 overexpressing breast cancer.
    Velázquez-Vega LE, Rivera-Robles M, Sánchez-Álvarez AO, Vivas-Mejía PE, Aponte-Reyes M, Cruz-Collazo AM, Grafals-Ruiz N, Dorta-Estremera S, Hernández-O'Farrill E, Vlaar CP, Dharmawardhane S.
    Transl Oncol; 2024 Jun 13; 44():101928. PubMed ID: 38489873
    [Abstract] [Full Text] [Related]

  • 7. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.
    Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M.
    J Biol Chem; 2003 Apr 11; 278(15):13207-15. PubMed ID: 12547822
    [Abstract] [Full Text] [Related]

  • 8. Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer.
    Cruz-Collazo A, Ruiz-Calderon JF, Picon H, Borrero-Garcia LD, Lopez I, Castillo-Pichardo L, Del Mar Maldonado M, Duconge J, Medina JI, Bayro MJ, Hernández-O'Farrill E, Vlaar CP, Dharmawardhane S.
    Mol Cancer Ther; 2021 Dec 11; 20(12):2420-2432. PubMed ID: 34607932
    [Abstract] [Full Text] [Related]

  • 9. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.
    Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF.
    Breast Cancer Res; 2005 Dec 11; 7(6):R965-74. PubMed ID: 16280046
    [Abstract] [Full Text] [Related]

  • 10. The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.
    Baird D, Feng Q, Cerione RA.
    Curr Biol; 2005 Jan 11; 15(1):1-10. PubMed ID: 15649357
    [Abstract] [Full Text] [Related]

  • 11. Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.
    Filipenko NR, Attwell S, Roskelley C, Dedhar S.
    Oncogene; 2005 Sep 01; 24(38):5837-49. PubMed ID: 15897874
    [Abstract] [Full Text] [Related]

  • 12. Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
    Rivera-Robles MJ, Medina-Velázquez J, Asencio-Torres GM, González-Crespo S, Rymond BC, Rodríguez-Medina J, Dharmawardhane S.
    Small GTPases; 2020 Nov 01; 11(6):430-440. PubMed ID: 29969362
    [Abstract] [Full Text] [Related]

  • 13. Structural requirements for PAK activation by Rac GTPases.
    Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH.
    J Biol Chem; 1998 Aug 21; 273(34):21512-8. PubMed ID: 9705280
    [Abstract] [Full Text] [Related]

  • 14. Targeting Rac and Cdc42 GEFs in Metastatic Cancer.
    Maldonado MDM, Medina JI, Velazquez L, Dharmawardhane S.
    Front Cell Dev Biol; 2020 Aug 21; 8():201. PubMed ID: 32322580
    [Abstract] [Full Text] [Related]

  • 15. Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.
    Zhou K, Wang Y, Gorski JL, Nomura N, Collard J, Bokoch GM.
    J Biol Chem; 1998 Jul 03; 273(27):16782-6. PubMed ID: 9642235
    [Abstract] [Full Text] [Related]

  • 16. Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.
    Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF.
    Neoplasia; 2007 Feb 03; 9(2):147-58. PubMed ID: 17356711
    [Abstract] [Full Text] [Related]

  • 17. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
    Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, Winkles JA, Loftus JC, Symons MH, Tran NL.
    Mol Cancer Res; 2012 Jul 03; 10(7):958-68. PubMed ID: 22571869
    [Abstract] [Full Text] [Related]

  • 18. Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac.
    Kawakatsu T, Ogita H, Fukuhara T, Fukuyama T, Minami Y, Shimizu K, Takai Y.
    J Biol Chem; 2005 Feb 11; 280(6):4940-7. PubMed ID: 15485841
    [Abstract] [Full Text] [Related]

  • 19. Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
    Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS.
    Breast Cancer Res; 2017 Jun 30; 19(1):74. PubMed ID: 28666462
    [Abstract] [Full Text] [Related]

  • 20. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.
    Lim L, Manser E, Leung T, Hall C.
    Eur J Biochem; 1996 Dec 01; 242(2):171-85. PubMed ID: 8973630
    [Abstract] [Full Text] [Related]

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