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124 related items for PubMed ID: 3712374

  • 1. Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
    DeGraw JI, Christie PH, Tagawa H, Kisliuk RL, Gaumont Y, Schmid FA, Sirotnak FM.
    J Med Chem; 1986 Jun; 29(6):1056-61. PubMed ID: 3712374
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
    DeGraw JI, Christie PH, Colwell WT, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):320-4. PubMed ID: 1732549
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
    DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1990 Jan 24; 33(1):212-5. PubMed ID: 2296020
    [Abstract] [Full Text] [Related]

  • 4. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1986 Jun 24; 29(6):1080-7. PubMed ID: 2423690
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.
    DeGraw JI, Christie PH, Brown EG, Kelly LF, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1984 Mar 24; 27(3):376-80. PubMed ID: 6699882
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM.
    J Med Chem; 1988 Nov 24; 31(11):2164-9. PubMed ID: 3184124
    [Abstract] [Full Text] [Related]

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  • 8. Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin.
    DeGraw JI, Colwell WT, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1986 Sep 24; 29(9):1786-9. PubMed ID: 3091834
    [Abstract] [Full Text] [Related]

  • 9. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
    Rosowsky A, Bader H, Kohler W, Freisheim JH, Moran RG.
    J Med Chem; 1988 Jul 24; 31(7):1338-44. PubMed ID: 2898531
    [Abstract] [Full Text] [Related]

  • 10. Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.
    Rosowsky A, Bader H, Freisheim JH.
    J Med Chem; 1991 Jan 24; 34(1):203-8. PubMed ID: 1992118
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
    Piper JR, Johnson CA, Otter GM, Sirotnak FM.
    J Med Chem; 1992 Aug 07; 35(16):3002-6. PubMed ID: 1501226
    [Abstract] [Full Text] [Related]

  • 12. Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
    Rosowsky A, Bader H, Radike-Smith M, Cucchi CA, Wick MM, Freisheim JH.
    J Med Chem; 1986 Sep 07; 29(9):1703-9. PubMed ID: 3462394
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.
    DeGraw JI, Brown VH, Tagawa H, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1982 Oct 07; 25(10):1227-30. PubMed ID: 7143361
    [Abstract] [Full Text] [Related]

  • 14. 10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1982 Jul 07; 25(7):877-80. PubMed ID: 7108907
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 07; 34(4):1447-54. PubMed ID: 2016722
    [Abstract] [Full Text] [Related]

  • 16. Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin.
    Rosowsky A, Freisheim JH, Bader H, Forsch RA, Susten SS, Cucchi CA, Frei E.
    J Med Chem; 1985 May 07; 28(5):660-7. PubMed ID: 3872941
    [Abstract] [Full Text] [Related]

  • 17. Reduced forms of aminopterin and methotrexate in L1210 lymphoma.
    Makulu DR, Fölsch E.
    J Natl Cancer Inst; 1977 Jul 07; 59(1):245-9. PubMed ID: 875056
    [Abstract] [Full Text] [Related]

  • 18. Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
    Rosowsky A, Freisheim JH, Moran RG, Solan VC, Bader H, Wright JE, Radike-Smith M.
    J Med Chem; 1986 May 07; 29(5):655-60. PubMed ID: 2871191
    [Abstract] [Full Text] [Related]

  • 19. Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.
    Rosowsky A, Bader H, Forsch RA, Moran RG, Freisheim JH.
    J Med Chem; 1988 Apr 07; 31(4):763-8. PubMed ID: 3351853
    [Abstract] [Full Text] [Related]

  • 20. Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.
    Rosowsky A, Moran RC, Forsch RA, Radike-Smith M, Colman PD, Wick MM, Freisheim JH.
    Biochem Pharmacol; 1986 Oct 01; 35(19):3327-33. PubMed ID: 3768024
    [Abstract] [Full Text] [Related]

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