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170 related items for PubMed ID: 37192550

  • 1. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases.
    Hausdorff M, Delpal A, Barelier S, Nicollet L, Canard B, Touret F, Colmant A, Coutard B, Vasseur JJ, Decroly E, Debart F.
    Eur J Med Chem; 2023 Aug 05; 256():115474. PubMed ID: 37192550
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
    Ahmed-Belkacem R, Sutto-Ortiz P, Guiraud M, Canard B, Vasseur JJ, Decroly E, Debart F.
    Eur J Med Chem; 2020 Sep 01; 201():112557. PubMed ID: 32563813
    [Abstract] [Full Text] [Related]

  • 3. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.
    Ahmed-Belkacem R, Hausdorff M, Delpal A, Sutto-Ortiz P, Colmant AMG, Touret F, Ogando NS, Snijder EJ, Canard B, Coutard B, Vasseur JJ, Decroly E, Debart F.
    J Med Chem; 2022 Apr 28; 65(8):6231-6249. PubMed ID: 35439007
    [Abstract] [Full Text] [Related]

  • 4. Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.
    Case JB, Ashbrook AW, Dermody TS, Denison MR.
    J Virol; 2016 Aug 15; 90(16):7248-7256. PubMed ID: 27252528
    [Abstract] [Full Text] [Related]

  • 5. Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19.
    Selvaraj C, Dinesh DC, Panwar U, Abhirami R, Boura E, Singh SK.
    J Biomol Struct Dyn; 2021 Aug 15; 39(13):4582-4593. PubMed ID: 32567979
    [Abstract] [Full Text] [Related]

  • 6. 3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors.
    Bobileva O, Bobrovs R, Sirma EE, Kanepe I, Bula AL, Patetko L, Ramata-Stunda A, Grinberga S, Jirgensons A, Jaudzems K.
    Molecules; 2023 Jan 12; 28(2):. PubMed ID: 36677825
    [Abstract] [Full Text] [Related]

  • 7. Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
    Kottur J, White KM, Rodriguez ML, Rechkoblit O, Quintana-Feliciano R, Nayar A, García-Sastre A, Aggarwal AK.
    PLoS Pathog; 2023 Jul 12; 19(7):e1011546. PubMed ID: 37523415
    [Abstract] [Full Text] [Related]

  • 8. Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
    Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M.
    SLAS Discov; 2021 Oct 12; 26(9):1200-1211. PubMed ID: 34192965
    [Abstract] [Full Text] [Related]

  • 9. N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition.
    Pan R, Kindler E, Cao L, Zhou Y, Zhang Z, Liu Q, Ebert N, Züst R, Sun Y, Gorbalenya AE, Perlman S, Thiel V, Chen Y, Guo D.
    mBio; 2022 Feb 22; 13(1):e0366221. PubMed ID: 35073761
    [Abstract] [Full Text] [Related]

  • 10. Synthetic Platforms for Characterizing and Targeting of SARS-CoV-2 Genome Capping Enzymes.
    Ornelas MY, Thomas AY, Johnson Rosas LI, Scoville RO, Mehta AP.
    ACS Synth Biol; 2022 Nov 18; 11(11):3759-3771. PubMed ID: 36331143
    [Abstract] [Full Text] [Related]

  • 11. A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases.
    Samrat SK, Bashir Q, Zhang R, Huang Y, Liu Y, Wu X, Brown T, Wang W, Zheng YG, Zhang QY, Chen Y, Li Z, Li H.
    Emerg Microbes Infect; 2023 Dec 18; 12(1):2204164. PubMed ID: 37060263
    [Abstract] [Full Text] [Related]

  • 12. N-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2.
    Ahmed-Belkacem R, Troussier J, Delpal A, Canard B, Vasseur JJ, Decroly E, Debart F.
    RSC Med Chem; 2024 Mar 20; 15(3):839-847. PubMed ID: 38516599
    [Abstract] [Full Text] [Related]

  • 13. Porcine Epidemic Diarrhea Virus Deficient in RNA Cap Guanine-N-7 Methylation Is Attenuated and Induces Higher Type I and III Interferon Responses.
    Lu Y, Cai H, Lu M, Ma Y, Li A, Gao Y, Zhou J, Gu H, Li J, Gu J.
    J Virol; 2020 Jul 30; 94(16):. PubMed ID: 32461321
    [Abstract] [Full Text] [Related]

  • 14. Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
    Imprachim N, Yosaatmadja Y, Newman JA.
    Nucleic Acids Res; 2023 Jan 11; 51(1):475-487. PubMed ID: 36546776
    [Abstract] [Full Text] [Related]

  • 15. The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
    Otava T, Šála M, Li F, Fanfrlík J, Devkota K, Perveen S, Chau I, Pakarian P, Hobza P, Vedadi M, Boura E, Nencka R.
    ACS Infect Dis; 2021 Aug 13; 7(8):2214-2220. PubMed ID: 34152728
    [Abstract] [Full Text] [Related]

  • 16. Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase.
    Chen Y, Tao J, Sun Y, Wu A, Su C, Gao G, Cai H, Qiu S, Wu Y, Ahola T, Guo D.
    J Virol; 2013 Jun 13; 87(11):6296-305. PubMed ID: 23536667
    [Abstract] [Full Text] [Related]

  • 17. Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.
    Pearson LA, Green CJ, Lin D, Petit AP, Gray DW, Cowling VH, Fordyce EAF.
    SLAS Discov; 2021 Jul 13; 26(6):749-756. PubMed ID: 33724070
    [Abstract] [Full Text] [Related]

  • 18. Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.
    Chen Y, Cai H, Pan J, Xiang N, Tien P, Ahola T, Guo D.
    Proc Natl Acad Sci U S A; 2009 Mar 03; 106(9):3484-9. PubMed ID: 19208801
    [Abstract] [Full Text] [Related]

  • 19. Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex.
    Chen J, Zhou Y, Wei X, Xu X, Qin Z, Ong CP, Ye ZW, Jin DY, Boitrel B, Yuan S, Chan JF, Li H, Sun H.
    ACS Infect Dis; 2024 Mar 08; 10(3):858-869. PubMed ID: 37897418
    [Abstract] [Full Text] [Related]

  • 20. Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex.
    Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z, Wu A, Sun Y, Yang Z, Tien P, Ahola T, Liang Y, Liu X, Guo D.
    PLoS Pathog; 2011 Oct 08; 7(10):e1002294. PubMed ID: 22022266
    [Abstract] [Full Text] [Related]

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