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105 related items for PubMed ID: 37285384

  • 1. A Phenylboronic Acid-Based Transition State Analogue Yields Nanomolar Inhibition of Mandelate Racemase.
    Kuehm OP, Hayden JA, Bearne SL.
    Biochemistry; 2023 Jun 20; 62(12):1929-1942. PubMed ID: 37285384
    [Abstract] [Full Text] [Related]

  • 2. Capturing the free energy of transition state stabilization: insights from the inhibition of mandelate racemase.
    Bearne SL.
    Philos Trans R Soc Lond B Biol Sci; 2023 Feb 27; 378(1871):20220041. PubMed ID: 36633273
    [Abstract] [Full Text] [Related]

  • 3. Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center.
    Sharma AN, Grandinetti L, Johnson ER, St Maurice M, Bearne SL.
    Biochemistry; 2020 Aug 25; 59(33):3026-3037. PubMed ID: 32786399
    [Abstract] [Full Text] [Related]

  • 4. An additional role for the Brønsted acid-base catalysts of mandelate racemase in transition state stabilization.
    Nagar M, Bearne SL.
    Biochemistry; 2015 Nov 10; 54(44):6743-52. PubMed ID: 26480244
    [Abstract] [Full Text] [Related]

  • 5. Hydrophobic nature of the active site of mandelate racemase.
    St Maurice M, Bearne SL.
    Biochemistry; 2004 Mar 09; 43(9):2524-32. PubMed ID: 14992589
    [Abstract] [Full Text] [Related]

  • 6. Reaction intermediate analogues for mandelate racemase: interaction between Asn 197 and the alpha-hydroxyl of the substrate promotes catalysis.
    St Maurice M, Bearne SL.
    Biochemistry; 2000 Nov 07; 39(44):13324-35. PubMed ID: 11063568
    [Abstract] [Full Text] [Related]

  • 7. Kinetics and thermodynamics of mandelate racemase catalysis.
    St Maurice M, Bearne SL.
    Biochemistry; 2002 Mar 26; 41(12):4048-58. PubMed ID: 11900548
    [Abstract] [Full Text] [Related]

  • 8. Structure of mandelate racemase with bound intermediate analogues benzohydroxamate and cupferron.
    Lietzan AD, Nagar M, Pellmann EA, Bourque JR, Bearne SL, St Maurice M.
    Biochemistry; 2012 Feb 14; 51(6):1160-70. PubMed ID: 22264153
    [Abstract] [Full Text] [Related]

  • 9. Redefining the minimal substrate tolerance of mandelate racemase. Racemization of trifluorolactate.
    Nagar M, Narmandakh A, Khalak Y, Bearne SL.
    Biochemistry; 2011 Oct 18; 50(41):8846-52. PubMed ID: 21894901
    [Abstract] [Full Text] [Related]

  • 10. A Paradigm for CH Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase.
    Bearne SL, St Maurice M.
    Adv Protein Chem Struct Biol; 2017 Oct 18; 109():113-160. PubMed ID: 28683916
    [Abstract] [Full Text] [Related]

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  • 13. Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis.
    Siddiqi F, Bourque JR, Jiang H, Gardner M, St Maurice M, Blouin C, Bearne SL.
    Biochemistry; 2005 Jun 28; 44(25):9013-21. PubMed ID: 15966725
    [Abstract] [Full Text] [Related]

  • 14. The role of residue S139 of mandelate racemase: synergistic effect of S139 and E317 on transition state stabilization.
    Gu J, Yu H.
    J Biomol Struct Dyn; 2012 Jun 28; 30(5):585-93. PubMed ID: 22731931
    [Abstract] [Full Text] [Related]

  • 15. Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant.
    Kallarakal AT, Mitra B, Kozarich JW, Gerlt JA, Clifton JG, Petsko GA, Kenyon GL.
    Biochemistry; 1995 Mar 07; 34(9):2788-97. PubMed ID: 7893690
    [Abstract] [Full Text] [Related]

  • 16. Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron.
    Bourque JR, Burley RK, Bearne SL.
    Bioorg Med Chem Lett; 2007 Jan 01; 17(1):105-8. PubMed ID: 17055725
    [Abstract] [Full Text] [Related]

  • 17. Mandelate racemase in pieces: effective concentrations of enzyme functional groups in the transition state.
    Bearne SL, Wolfenden R.
    Biochemistry; 1997 Feb 18; 36(7):1646-56. PubMed ID: 9048548
    [Abstract] [Full Text] [Related]

  • 18. [Genome mining and characterization of a new mandelate racemase].
    Zhou M, Tang C, Xu J, Yu H.
    Sheng Wu Gong Cheng Xue Bao; 2018 Jun 25; 34(6):897-905. PubMed ID: 29943535
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  • 20. Altering the binding determinant on the interdigitating loop of mandelate racemase shifts specificity towards that of d-tartrate dehydratase.
    Nagar M, Hayden JA, Sagey E, Worthen G, Park M, Sharma AN, Fetter CM, Kuehm OP, Bearne SL.
    Arch Biochem Biophys; 2022 Mar 30; 718():109119. PubMed ID: 35016855
    [Abstract] [Full Text] [Related]

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