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166 related items for PubMed ID: 37541759

  • 1. Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood-Brain Barrier Endothelium.
    Wang Z, Sharda N, Omtri RS, Li L, Kandimalla KK.
    Mol Pharmacol; 2023 Nov; 104(5):203-213. PubMed ID: 37541759
    [Abstract] [Full Text] [Related]

  • 2. Distinct Uptake Kinetics of Alzheimer Disease Amyloid-β 40 and 42 at the Blood-Brain Barrier Endothelium.
    Sharda N, Ahlschwede KM, Curran GL, Lowe VJ, Kandimalla KK.
    J Pharmacol Exp Ther; 2021 Mar; 376(3):482-490. PubMed ID: 33303699
    [Abstract] [Full Text] [Related]

  • 3. Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery.
    Omtri RS, Davidson MW, Arumugam B, Poduslo JF, Kandimalla KK.
    Mol Pharm; 2012 Jul 02; 9(7):1887-97. PubMed ID: 22574751
    [Abstract] [Full Text] [Related]

  • 4. Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium.
    Wang Z, Sharda N, Curran GL, Li L, Lowe VJ, Kandimalla KK.
    Mol Pharm; 2021 Nov 01; 18(11):4148-4161. PubMed ID: 34664956
    [Abstract] [Full Text] [Related]

  • 5. Differential Effects of Alzheimer's Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking.
    Omtri RS, Thompson KJ, Tang X, Gali CC, Panzenboeck U, Davidson MW, Kalari KR, Kandimalla KK.
    Neuroscience; 2018 Mar 01; 373():159-168. PubMed ID: 29337241
    [Abstract] [Full Text] [Related]

  • 6. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein.
    Kandimalla KK, Scott OG, Fulzele S, Davidson MW, Poduslo JF.
    PLoS One; 2009 Mar 01; 4(2):e4627. PubMed ID: 19247480
    [Abstract] [Full Text] [Related]

  • 7. Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature.
    Agyare EK, Leonard SR, Curran GL, Yu CC, Lowe VJ, Paravastu AK, Poduslo JF, Kandimalla KK.
    Mol Pharm; 2013 May 06; 10(5):1557-65. PubMed ID: 23249146
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.
    Shackleton B, Crawford F, Bachmeier C.
    Fluids Barriers CNS; 2016 Aug 08; 13(1):14. PubMed ID: 27503326
    [Abstract] [Full Text] [Related]

  • 9. Distinct Effects of Beta-Amyloid, Its Isomerized and Phosphorylated Forms on the Redox Status and Mitochondrial Functioning of the Blood-Brain Barrier Endothelium.
    Petrovskaya AV, Tverskoi AM, Barykin EP, Varshavskaya KB, Dalina AA, Mitkevich VA, Makarov AA, Petrushanko IY.
    Int J Mol Sci; 2022 Dec 22; 24(1):. PubMed ID: 36613623
    [Abstract] [Full Text] [Related]

  • 10. Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain.
    Swaminathan SK, Ahlschwede KM, Sarma V, Curran GL, Omtri RS, Decklever T, Lowe VJ, Poduslo JF, Kandimalla KK.
    J Cereb Blood Flow Metab; 2018 May 22; 38(5):904-918. PubMed ID: 28569090
    [Abstract] [Full Text] [Related]

  • 11. Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling.
    Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, Kaddoumi A.
    Neuropharmacology; 2014 Apr 22; 79():668-78. PubMed ID: 24467845
    [Abstract] [Full Text] [Related]

  • 12. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier.
    Zhou AL, Swaminathan SK, Salian VS, Wang L, Curran GL, Min HK, Lowe VJ, Kandimalla KK.
    Mol Pharm; 2024 May 06; 21(5):2176-2186. PubMed ID: 38625027
    [Abstract] [Full Text] [Related]

  • 13. High-Density Lipoprotein Mimetic Peptide 4F Efficiently Crosses the Blood-Brain Barrier and Modulates Amyloid-β Distribution between Brain and Plasma.
    Swaminathan SK, Zhou AL, Ahlschwede KM, Curran GL, Lowe VJ, Li L, Kandimalla KK.
    J Pharmacol Exp Ther; 2020 Nov 06; 375(2):308-316. PubMed ID: 32778535
    [Abstract] [Full Text] [Related]

  • 14. Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier.
    Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV.
    Mol Neurodegener; 2023 Jan 27; 18(1):7. PubMed ID: 36707892
    [Abstract] [Full Text] [Related]

  • 15. Distinctive contribution of two additional residues in protein aggregation of Aβ42 and Aβ40 isoforms.
    Im D, Choi TS.
    BMB Rep; 2024 Jun 27; 57(6):263-272. PubMed ID: 38835114
    [Abstract] [Full Text] [Related]

  • 16. Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.
    Parodi-Rullán R, Ghiso J, Cabrera E, Rostagno A, Fossati S.
    Aging Cell; 2020 Nov 27; 19(11):e13258. PubMed ID: 33155752
    [Abstract] [Full Text] [Related]

  • 17. iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta.
    Ding Y, Palecek SP, Shusta EV.
    Fluids Barriers CNS; 2024 Oct 11; 21(1):79. PubMed ID: 39394110
    [Abstract] [Full Text] [Related]

  • 18. New Evidence for P-gp-Mediated Export of Amyloid-β PEPTIDES in Molecular, Blood-Brain Barrier and Neuronal Models.
    Chai AB, Hartz AMS, Gao X, Yang A, Callaghan R, Gelissen IC.
    Int J Mol Sci; 2020 Dec 29; 22(1):. PubMed ID: 33383667
    [Abstract] [Full Text] [Related]

  • 19. Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway.
    Hartz AM, Zhong Y, Wolf A, LeVine H, Miller DS, Bauer B.
    J Neurosci; 2016 Feb 10; 36(6):1930-41. PubMed ID: 26865616
    [Abstract] [Full Text] [Related]

  • 20. Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients.
    Kung MP, Skovronsky DM, Hou C, Zhuang ZP, Gur TL, Zhang B, Trojanowski JQ, Lee VM, Kung HF.
    J Mol Neurosci; 2003 Feb 10; 20(1):15-24. PubMed ID: 12663930
    [Abstract] [Full Text] [Related]

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