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Journal Abstract Search

143 related items for PubMed ID: 3754453

  • 1. The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action.
    Stratford IJ, Walling JM, Silver AR.
    Br J Cancer; 1986 Mar; 53(3):339-44. PubMed ID: 3754453
    [Abstract] [Full Text] [Related]

  • 2. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.
    Sapora O, Paone A, Maggi A, Jenner TJ, O'Neill P.
    Biochem Pharmacol; 1992 Oct 06; 44(7):1341-7. PubMed ID: 1417957
    [Abstract] [Full Text] [Related]

  • 3. RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.
    Stratford IJ, O'Neill P, Sheldon PW, Silver AR, Walling JM, Adams GE.
    Biochem Pharmacol; 1986 Jan 01; 35(1):105-9. PubMed ID: 3753579
    [No Abstract] [Full Text] [Related]

  • 4. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.
    Jenner TJ, Sapora O, O'Neill P, Fielden EM.
    Biochem Pharmacol; 1988 Oct 15; 37(20):3837-42. PubMed ID: 3190731
    [Abstract] [Full Text] [Related]

  • 5. Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues.
    Walling JM, Stratford IJ, Adams GE, Silver AR, Ahmed I, Jenkins TC, Fielden EM.
    Int J Radiat Oncol Biol Phys; 1986 Jul 15; 12(7):1083-6. PubMed ID: 3755712
    [Abstract] [Full Text] [Related]

  • 6. Studies on the toxicity of RSU-1069.
    Whitmore GF, Gulyas S.
    Int J Radiat Oncol Biol Phys; 1986 Jul 15; 12(7):1219-22. PubMed ID: 3755716
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  • 7. Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069.
    Hill RP, Gulyas S, Whitmore GF.
    Br J Cancer; 1986 Jun 15; 53(6):743-51. PubMed ID: 3755053
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  • 9. Variation of the radiosensitizing efficiency of RSU-1069 with pre-irradiation contact times: a rapid mix study.
    Austen KR, Jenner TJ, O'Neill P, Fielden EM.
    Int J Radiat Biol Relat Stud Phys Chem Med; 1987 Aug 15; 52(2):281-8. PubMed ID: 3497125
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  • 10. Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo.
    Adams GE, Ahmed I, Sheldon PW, Stratford IJ.
    Br J Cancer; 1984 May 15; 49(5):571-7. PubMed ID: 6547051
    [Abstract] [Full Text] [Related]

  • 11. RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo.
    Adams GE, Ahmed I, Sheldon PW, Stratford IJ.
    Int J Radiat Oncol Biol Phys; 1984 Sep 15; 10(9):1653-6. PubMed ID: 6548211
    [Abstract] [Full Text] [Related]

  • 12. Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin.
    Roizin-Towle L, Pirro JP, Hall EJ.
    Radiat Res; 1990 Oct 15; 124(1 Suppl):S50-5. PubMed ID: 2236511
    [Abstract] [Full Text] [Related]

  • 13. Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro.
    Silver AR, O'Neill P, Jenkins TC.
    Biochem Pharmacol; 1985 Oct 01; 34(19):3537-42. PubMed ID: 3902026
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  • 15. Comparative DNA damage induced by nitroimidazole-aziridine drugs: 1. Effects of methyl substitution on drug action.
    Dale LD, Tocher JH, Edwards DI.
    Anticancer Drug Des; 1988 Dec 01; 3(3):169-75. PubMed ID: 3207464
    [Abstract] [Full Text] [Related]

  • 16. Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas.
    Cole S, Stratford IJ, Adams GE, Fielden EM, Jenkins TC.
    Radiat Res; 1990 Oct 01; 124(1 Suppl):S38-43. PubMed ID: 2236508
    [Abstract] [Full Text] [Related]

  • 17. The repair of DNA damage induced in V79 mammalian cells by the nitroimidazole-aziridine, RSU-1069. Implications for radiosensitization.
    Jenner TJ, O'Neill P, Crump PW, Fielden EM, Sapora O, Santodonato L.
    Biochem Pharmacol; 1991 Oct 09; 42(9):1705-10. PubMed ID: 1930296
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  • 20. Assessment of the repair and damage of DNA induced by parent and reduced RSU-1069, a 2-nitroimidazole-aziridine.
    O'Neill P, Cunniffe SM.
    Int J Radiat Oncol Biol Phys; 1989 Apr 09; 16(4):963-6. PubMed ID: 2649467
    [Abstract] [Full Text] [Related]

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