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PUBMED FOR HANDHELDS

Journal Abstract Search


233 related items for PubMed ID: 3768024

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  • 24. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
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  • 25. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
    Rosowsky A, Forsch RA, Wright JE.
    J Med Chem; 2004 Dec 30; 47(27):6958-63. PubMed ID: 15615544
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  • 27. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
    Kuehl M, Brixner DI, Broom AD, Avery TL, Blakley RL.
    Cancer Res; 1988 Mar 15; 48(6):1481-8. PubMed ID: 2449950
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  • 29. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A, Wright JE, Vaidya CM, Bader H, Forsch RA, Mota CE, Pardo J, Chen CS, Chen YN.
    J Med Chem; 1998 Dec 17; 41(26):5310-9. PubMed ID: 9857098
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  • 32. Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.
    Jackman AL, Taylor GA, O'Connor BM, Bishop JA, Moran RG, Calvert AH.
    Cancer Res; 1990 Sep 01; 50(17):5212-8. PubMed ID: 2386929
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  • 36. Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.
    Sirotnak FM, Schmid FA, Otter GM, Piper JR, Montgomery JA.
    Cancer Res; 1988 Oct 15; 48(20):5686-91. PubMed ID: 3167828
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  • 37. Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.
    Rosowsky A, Forsch R, Uren J, Wick M, Kumar AA, Freisheim JH.
    J Med Chem; 1983 Dec 15; 26(12):1719-24. PubMed ID: 6139480
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  • 38. Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
    Rumberger BG, Schmid FA, Otter GM, Sirotnak FM.
    Cancer Commun; 1990 Dec 15; 2(9):305-10. PubMed ID: 2206778
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  • 39. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 15; 48(3):459-71. PubMed ID: 7565626
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  • 40. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
    Rosowsky A, Bader H, Wright JE, Keyomarsi K, Matherly LH.
    J Med Chem; 1994 Jul 08; 37(14):2167-74. PubMed ID: 8035423
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