These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Ward R, Li W, Abdul Y, Jackson L, Dong G, Jamil S, Filosa J, Fagan SC, Ergul A. Pharmacol Res; 2019 Apr; 142():237-250. PubMed ID: 30818045 [Abstract] [Full Text] [Related]
4. A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease. Huang S, Chen Z, Fan B, Chen Y, Zhou L, Jiang B, Long H, Zhong W, Li X, Li Y. J Neuroimmunol; 2021 May 15; 354():577543. PubMed ID: 33714750 [Abstract] [Full Text] [Related]
8. Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death. Matsuoka T, Yoshimatsu G, Sakata N, Kawakami R, Tanaka T, Yamada T, Yoshida Y, Hasegawa S, Kodama S. Sci Rep; 2020 Oct 21; 10(1):17920. PubMed ID: 33087823 [Abstract] [Full Text] [Related]
9. MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy. Hong Y, Wei C, Fu M, Li X, Zhang H, Yao B. Int Immunopharmacol; 2024 Jan 05; 126():111236. PubMed ID: 38039716 [Abstract] [Full Text] [Related]
10. Ameliorative effect of selective NLRP3 inflammasome inhibitor MCC950 in an ovalbumin-induced allergic rhinitis murine model. Zhang W, Ba G, Tang R, Li M, Lin H. Int Immunopharmacol; 2020 Jun 05; 83():106394. PubMed ID: 32193102 [Abstract] [Full Text] [Related]
11. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA. Brain Behav Immun; 2017 Mar 05; 61():306-316. PubMed ID: 28003153 [Abstract] [Full Text] [Related]
12. MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats. Zhao J, Guo X, Wang B, Yang Z, Huang T, Guo D, Zhang M, Song J. Neurochem Res; 2020 Sep 05; 45(9):2020-2031. PubMed ID: 32474832 [Abstract] [Full Text] [Related]
13. The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence. Shi Y, Zhao L, Wang J, Liu S, Zhang Y, Qin Q. Eur J Pharmacol; 2022 Dec 15; 937():175364. PubMed ID: 36336012 [Abstract] [Full Text] [Related]
14. Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway. Wang A, Zhong G, Ying M, Fang Z, Chen Y, Wang H, Wang C, Liu C, Guo Y. Neuropharmacology; 2024 Oct 01; 257():110063. PubMed ID: 38972372 [Abstract] [Full Text] [Related]
15. NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation. Li S, Lin Q, Shao X, Mou S, Gu L, Wang L, Zhang Z, Shen J, Zhou Y, Qi C, Jin H, Pang H, Ni Z. Exp Cell Res; 2019 Oct 01; 383(1):111488. PubMed ID: 31276670 [Abstract] [Full Text] [Related]
16. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Niu L, Luo SS, Xu Y, Wang Z, Luo D, Yang H, Li W, He J, Zhong XL, Liu ZH, Zeng JY, Cao WY, Wan W. Neurobiol Learn Mem; 2020 Nov 01; 175():107301. PubMed ID: 32882398 [Abstract] [Full Text] [Related]
17. Nlrp3 Inflammasome Inhibitor MCC950 Ameliorates Obliterative Bronchiolitis by Inhibiting Th1/Th17 Response and Promoting Treg Response After Orthotopic Tracheal Transplantation in Mice. Xu KY, Tong S, Wu CY, Ding XC, Chen JL, Ming Y, Wang SH. Transplantation; 2020 Jun 01; 104(6):e151-e163. PubMed ID: 32108749 [Abstract] [Full Text] [Related]
18. NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report. van der Heijden T, Kritikou E, Venema W, van Duijn J, van Santbrink PJ, Slütter B, Foks AC, Bot I, Kuiper J. Arterioscler Thromb Vasc Biol; 2017 Aug 01; 37(8):1457-1461. PubMed ID: 28596375 [Abstract] [Full Text] [Related]