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Journal Abstract Search

116 related items for PubMed ID: 38973505

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  • 3. Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation.
    Ghosh AK, Yashchuk S, Mizuno A, Chakraborty N, Agniswamy J, Wang YF, Aoki M, Gomez PM, Amano M, Weber IT, Mitsuya H.
    ChemMedChem; 2015 Jan; 10(1):107-15. PubMed ID: 25336073
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  • 6. Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
    Ghosh AK, R Nyalapatla P, Kovela S, Rao KV, Brindisi M, Osswald HL, Amano M, Aoki M, Agniswamy J, Wang YF, Weber IT, Mitsuya H.
    J Med Chem; 2018 May 24; 61(10):4561-4577. PubMed ID: 29763303
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  • 8. Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.
    Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J, Wang YF, Weber IT, Amano M, Mitsuya H.
    Org Biomol Chem; 2015 Dec 28; 13(48):11607-21. PubMed ID: 26462551
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  • 9. Design and synthesis of HIV-1 protease inhibitors. Novel tetrahydrofuran P2/P2'-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex.
    Oscarsson K, Lahmann M, Lindberg J, Kangasmetsä J, Unge T, Oscarson S, Hallberg A, Samuelsson B.
    Bioorg Med Chem; 2003 Mar 20; 11(6):1107-15. PubMed ID: 12614898
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  • 15. Design and synthesis of potent HIV-1 protease inhibitors with (S)-tetrahydrofuran-tertiary amine-acetamide as P2-ligand: Structure-activity studies and biological evaluation.
    Bai X, Yang Z, Zhu M, Dong B, Zhou L, Zhang G, Wang J, Wang Y.
    Eur J Med Chem; 2017 Sep 08; 137():30-44. PubMed ID: 28554091
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  • 16. Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
    Ghosh AK, Rao KV, Nyalapatla PR, Osswald HL, Martyr CD, Aoki M, Hayashi H, Agniswamy J, Wang YF, Bulut H, Das D, Weber IT, Mitsuya H.
    J Med Chem; 2017 May 25; 60(10):4267-4278. PubMed ID: 28418652
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  • 20. Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
    Ghosh AK, Brindisi M, Nyalapatla PR, Takayama J, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.
    Bioorg Med Chem; 2017 Oct 01; 25(19):5114-5127. PubMed ID: 28434781
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