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158 related items for PubMed ID: 39274913

  • 1. Design, Synthesis, and Anticancer Activity of Novel Enmein-Type Diterpenoid Derivatives Targeting the PI3K/Akt/mTOR Signaling Pathway.
    Wang J, Wang L, Zhang Y, Pan S, Lin Y, Wu J, Bu M.
    Molecules; 2024 Aug 27; 29(17):. PubMed ID: 39274913
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, Cytotoxicity and Antimicrobial Activity of New Enmein-type Kauranoid Diterpenoid Derivatives.
    Li D, Han T, Hu X, Tian K, Xu S, Zhou T, Cheng K, Li Z, Hua H, Xu J.
    Anticancer Agents Med Chem; 2017 Aug 27; 17(12):1679-1688. PubMed ID: 28403782
    [Abstract] [Full Text] [Related]

  • 3. Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics.
    Gao X, Li J, Wang M, Xu S, Liu W, Zang L, Li Z, Hua H, Xu J, Li D.
    Eur J Med Chem; 2018 Feb 25; 146():588-598. PubMed ID: 29407983
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  • 4. Synthesis, anticancer evaluation and mechanism studies of novel indolequinone derivatives of ursolic acid.
    Wang WY, Wu WY, Li AL, Liu QS, Sun Y, Gu W.
    Bioorg Chem; 2021 Apr 25; 109():104705. PubMed ID: 33618252
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  • 5. Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/mTOR signaling pathway in human breast cancer cells.
    Kamal A, Lakshma Nayak V, Nagesh N, Vishnuvardhan MV, Subba Reddy NV.
    Bioorg Chem; 2016 Jun 25; 66():124-31. PubMed ID: 27149364
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
    Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y.
    Bioorg Chem; 2021 Jun 25; 111():104872. PubMed ID: 33838560
    [Abstract] [Full Text] [Related]

  • 7. Bioactive enmein-type 6,7-seco-ent-kaurane diterpenoids: natural products, synthetic derivatives and apoptosis related mechanism.
    Li H, Sun B, Wang M, Hu X, Gao X, Xu S, Xu Y, Xu J, Hua H, Li D.
    Arch Pharm Res; 2018 Nov 25; 41(11):1051-1061. PubMed ID: 30242610
    [Abstract] [Full Text] [Related]

  • 8. Lupeol-3-carbamate Derivatives: Synthesis and Biological Evaluation as Potential Antitumor Agents.
    Tian S, Zhao Y, Deng S, Hou L, Song J, Wang M, Bu M.
    Molecules; 2024 Aug 23; 29(17):. PubMed ID: 39274838
    [Abstract] [Full Text] [Related]

  • 9. Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy.
    Xu T, Tian W, Zhang Q, Liu J, Liu Z, Jin J, Guo Y, Bai LP.
    Bioorg Chem; 2021 Oct 23; 115():105257. PubMed ID: 34426156
    [Abstract] [Full Text] [Related]

  • 10. Hydrogen sulfide releasing enmein-type diterpenoid derivatives as apoptosis inducers through mitochondria-related pathways.
    Xu F, Gao X, Li H, Xu S, Li X, Hu X, Li Z, Xu J, Hua H, Li D.
    Bioorg Chem; 2019 Feb 23; 82():192-203. PubMed ID: 30326401
    [Abstract] [Full Text] [Related]

  • 11. Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway.
    Kattan SW, Nafie MS, Elmgeed GA, Alelwani W, Badar M, Tantawy MA.
    J Steroid Biochem Mol Biol; 2020 Apr 23; 198():105604. PubMed ID: 31982513
    [Abstract] [Full Text] [Related]

  • 12. 3-Arylamino-quinoxaline-2-carboxamides inhibit the PI3K/Akt/mTOR signaling pathways to activate P53 and induce apoptosis.
    Chen NY, Lu K, Yuan JM, Li XJ, Gu ZY, Pan CX, Mo DL, Su GF.
    Bioorg Chem; 2021 Sep 23; 114():105101. PubMed ID: 34175723
    [Abstract] [Full Text] [Related]

  • 13. Luteoloside induces G0/G1 arrest and pro-death autophagy through the ROS-mediated AKT/mTOR/p70S6K signalling pathway in human non-small cell lung cancer cell lines.
    Zhou M, Shen S, Zhao X, Gong X.
    Biochem Biophys Res Commun; 2017 Dec 09; 494(1-2):263-269. PubMed ID: 29024631
    [Abstract] [Full Text] [Related]

  • 14. New quinoline/chalcone hybrids as anti-cancer agents: Design, synthesis, and evaluations of cytotoxicity and PI3K inhibitory activity.
    Abbas SH, Abd El-Hafeez AA, Shoman ME, Montano MM, Hassan HA.
    Bioorg Chem; 2019 Feb 09; 82():360-377. PubMed ID: 30428415
    [Abstract] [Full Text] [Related]

  • 15. Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
    Hu X, Bai Z, Qiao J, Li H, Xu S, Wang X, Xu Y, Xu J, Hua H, Li D.
    Eur J Med Chem; 2019 Jun 01; 171():169-179. PubMed ID: 30921757
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway.
    Lv L, Song K, Xiao Y, Zheng J, Zhang W, Li L, Wei Y, Chen H, He Y, Guo Z, Nie S.
    Bioorg Chem; 2024 Oct 01; 151():107648. PubMed ID: 39032406
    [Abstract] [Full Text] [Related]

  • 17. Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway.
    Wang T, Zou J, Wu Q, Wang R, Yuan CL, Shu J, Zhai BB, Huang XT, Liu NZ, Hua FY, Wang XC, Mei WJ.
    Eur J Pharmacol; 2021 Dec 05; 912():174586. PubMed ID: 34710368
    [Abstract] [Full Text] [Related]

  • 18. S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.
    Zhang C, Yang N, Yang CH, Ding HS, Luo C, Zhang Y, Wu MJ, Zhang XW, Shen X, Jiang HL, Meng LH, Ding J.
    PLoS One; 2009 Dec 05; 4(3):e4881. PubMed ID: 19293927
    [Abstract] [Full Text] [Related]

  • 19. Design, Synthesis, and Antitumor Activity of Isoliquiritigenin Amino Acid Ester Derivatives.
    Liu C, Liu X, Ma Q, Su F, Cai E.
    Molecules; 2024 Jun 03; 29(11):. PubMed ID: 38893517
    [Abstract] [Full Text] [Related]

  • 20. Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells.
    Pan RR, Zhang CY, Li Y, Zhang BB, Zhao L, Ye Y, Song YN, Zhang M, Tie HY, Zhang H, Zhu JY.
    J Nat Prod; 2020 Apr 24; 83(4):1238-1248. PubMed ID: 32223193
    [Abstract] [Full Text] [Related]

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