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128 related items for PubMed ID: 3933498

  • 1. Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid.
    Bjorge SM, Baillie TA.
    Biochem Biophys Res Commun; 1985 Oct 15; 132(1):245-52. PubMed ID: 3933498
    [Abstract] [Full Text] [Related]

  • 2. On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver.
    Gregersen N, Mortensen PB, Kølvraa S.
    Pediatr Res; 1983 Oct 15; 17(10):828-34. PubMed ID: 6634246
    [Abstract] [Full Text] [Related]

  • 3. Studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid, a metabolite of the antiepileptic drug valproic acid. Evidence for the formation of chemically reactive intermediates.
    Rettenmeier AW, Prickett KS, Gordon WP, Bjorge SM, Chang SL, Levy RH, Baillie TA.
    Drug Metab Dispos; 1985 Oct 15; 13(1):81-96. PubMed ID: 2858383
    [Abstract] [Full Text] [Related]

  • 4. Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
    Kassahun K, Hu P, Grillo MP, Davis MR, Jin L, Baillie TA.
    Chem Biol Interact; 1994 Mar 15; 90(3):253-75. PubMed ID: 8168173
    [Abstract] [Full Text] [Related]

  • 5. Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes.
    Aires CC, Soveral G, Luís PB, ten Brink HJ, de Almeida IT, Duran M, Wanders RJ, Silva MF.
    FEBS Lett; 2008 Oct 15; 582(23-24):3359-66. PubMed ID: 18775709
    [Abstract] [Full Text] [Related]

  • 6. Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status.
    Tang W, Borel AG, Fujimiya T, Abbott FS.
    Chem Res Toxicol; 1995 Oct 15; 8(5):671-82. PubMed ID: 7548749
    [Abstract] [Full Text] [Related]

  • 7. In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analog 4-pentenoic acid.
    Kassahun K, Abbott F.
    Drug Metab Dispos; 1993 Oct 15; 21(6):1098-106. PubMed ID: 7905390
    [Abstract] [Full Text] [Related]

  • 8. Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid.
    Rettenmeier AW, Gordon WP, Prickett KS, Levy RH, Lockard JS, Thummel KE, Baillie TA.
    Drug Metab Dispos; 1986 Oct 15; 14(4):443-53. PubMed ID: 2873992
    [Abstract] [Full Text] [Related]

  • 9. The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes.
    Porubek DJ, Grillo MP, Baillie TA.
    Drug Metab Dispos; 1989 Oct 15; 17(2):123-30. PubMed ID: 2565201
    [Abstract] [Full Text] [Related]

  • 10. Biotransformation and pharmacokinetics in the rhesus monkey of 2-n-propyl-4-pentenoic acid, a toxic metabolite of valproic acid.
    Rettenmeier AW, Gordon WP, Prickett KS, Levy RH, Baillie TA.
    Drug Metab Dispos; 1986 Oct 15; 14(4):454-64. PubMed ID: 2873993
    [Abstract] [Full Text] [Related]

  • 11. Reversal of the adverse chronic effects of the unsaturated derivative of valproic acid--2-n-propyl-4-pentenoic acid--on ketogenesis and liver coenzyme A metabolism by a single injection of pantothenate, carnitine, and acetylcysteine in developing mice.
    Thurston JH, Hauhart RE.
    Pediatr Res; 1993 Jan 15; 33(1):72-6. PubMed ID: 8433865
    [Abstract] [Full Text] [Related]

  • 12. Influence of valproic acid on hepatic carbohydrate and lipid metabolism.
    Becker CM, Harris RA.
    Arch Biochem Biophys; 1983 Jun 15; 223(2):381-92. PubMed ID: 6407400
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of 4-pentenoic acid and inhibition of thiolase by metabolites of 4-pentenoic acid.
    Schulz H.
    Biochemistry; 1983 Apr 12; 22(8):1827-32. PubMed ID: 6133549
    [Abstract] [Full Text] [Related]

  • 14. Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.
    Silva MF, Ruiter JP, IJlst L, Jakobs C, Duran M, de Almeida IT, Wanders RJ.
    Chem Biol Interact; 2001 Sep 28; 137(3):203-12. PubMed ID: 11566289
    [Abstract] [Full Text] [Related]

  • 15. Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations.
    Bjorge SM, Baillie TA.
    Drug Metab Dispos; 1991 Sep 28; 19(4):823-9. PubMed ID: 1680661
    [Abstract] [Full Text] [Related]

  • 16. Comparative transfer of valproic acid and of an active metabolite into brain and liver: possible pharmacological and toxicological consequences.
    Löscher W, Nau H.
    Arch Int Pharmacodyn Ther; 1984 Aug 28; 270(2):192-202. PubMed ID: 6435554
    [Abstract] [Full Text] [Related]

  • 17. Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats.
    Kadota Y, Toyoda T, Hayashi-Kato M, Kitaura Y, Shimomura Y.
    Metabolism; 2015 Sep 28; 64(9):1157-64. PubMed ID: 26104959
    [Abstract] [Full Text] [Related]

  • 18. Evidence for the synthesis of the multi-positional isomers of monounsaturated fatty acid in Methylococcus capsusatus by the anaerobic pathway.
    Jahnke LL, Diggs K.
    FEMS Microbiol Lett; 1989 Sep 28; 58():183-8. PubMed ID: 11542184
    [Abstract] [Full Text] [Related]

  • 19. In vitro effects of valproate and valproate metabolites on mitochondrial oxidations. Relevance of CoA sequestration to the observed inhibitions.
    Ponchaut S, van Hoof F, Veitch K.
    Biochem Pharmacol; 1992 Jun 09; 43(11):2435-42. PubMed ID: 1610408
    [Abstract] [Full Text] [Related]

  • 20. Action of the antiepileptic drug, valproic acid, on fatty acid oxidation in isolated rat hepatocytes.
    Coudé FX, Grimber G, Pelet A, Benoit Y.
    Biochem Biophys Res Commun; 1983 Sep 15; 115(2):730-6. PubMed ID: 6414476
    [Abstract] [Full Text] [Related]

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