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115 related items for PubMed ID: 3950869

  • 1. Metabolism of spironolactone by adrenocortical and hepatic microsomes: relationship to cytochrome P-450 destruction.
    Sherry JH, O'Donnell JP, Flowers L, Lacagnin LB, Colby HD.
    J Pharmacol Exp Ther; 1986 Mar; 236(3):675-80. PubMed ID: 3950869
    [Abstract] [Full Text] [Related]

  • 2. Spironolactone inhibition of cortisol production by guinea pig adrenocortical cells.
    Rourke KA, Colby HD.
    Horm Metab Res; 1990 Nov; 22(11):573-5. PubMed ID: 2177032
    [Abstract] [Full Text] [Related]

  • 3. Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone.
    Colby HD, O'Donnell JP, Flowers NL, Kossor DC, Johnson PB, Levitt M.
    Toxicology; 1991 Apr 08; 67(2):143-54. PubMed ID: 2031249
    [Abstract] [Full Text] [Related]

  • 4. Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450.
    Kossor DC, Kominami S, Takemori S, Colby HD.
    Mol Pharmacol; 1991 Aug 08; 40(2):321-5. PubMed ID: 1875914
    [Abstract] [Full Text] [Related]

  • 5. Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase.
    Ng SF, Waxman DJ.
    Cancer Res; 1990 Feb 01; 50(3):464-71. PubMed ID: 2105156
    [Abstract] [Full Text] [Related]

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  • 7. Mechanisms responsible for the thermal sensitivity of adrenal microsomal monooxygenases.
    Colby HD, Johnson PB, Pope MR.
    Drug Metab Dispos; 1991 Feb 01; 19(3):679-82. PubMed ID: 1680636
    [Abstract] [Full Text] [Related]

  • 8. Conversion of spironolactone to 7 alpha-thiomethylspironolactone by hepatic and renal microsomes.
    LaCagnin LB, Lutsie P, Colby HD.
    Biochem Pharmacol; 1987 Oct 15; 36(20):3439-44. PubMed ID: 3675606
    [Abstract] [Full Text] [Related]

  • 9. Adrenal mitochondrial metabolism of spironolactone. Absence of metabolic activation.
    Flowers NL, Sherry JH, O'Donnell JP, Colby HD.
    Biochem Pharmacol; 1988 Apr 15; 37(8):1591-5. PubMed ID: 3358788
    [Abstract] [Full Text] [Related]

  • 10. Mechanism of action of spironolactone on adrenocortical function in guinea pigs.
    Greiner JW, Kramer RE, Jarrell J, Colby HD.
    J Pharmacol Exp Ther; 1976 Sep 15; 198(3):709-15. PubMed ID: 978470
    [Abstract] [Full Text] [Related]

  • 11. Destruction of testicular cytochrome P-450 by 7 alpha-thiospironolactone is catalyzed by the 17 alpha-hydroxylase.
    Kossor DC, Kominami S, Takemori S, Colby HD.
    J Steroid Biochem Mol Biol; 1992 May 15; 42(3-4):421-4. PubMed ID: 1606053
    [Abstract] [Full Text] [Related]

  • 12. Metabolism of 4-chlorobiphenyl by guinea pig adrenocortical and hepatic microsomes.
    Eacho PI, O'Donnell JP, Colby HD.
    Biochem Pharmacol; 1984 Nov 15; 33(22):3627-32. PubMed ID: 6334521
    [Abstract] [Full Text] [Related]

  • 13. Dose-dependent actions of spironolactone on the inner and outer zones of the guinea pig adrenal cortex.
    Kossor DC, Colby HD.
    Pharmacology; 1992 Nov 15; 45(1):27-33. PubMed ID: 1508965
    [Abstract] [Full Text] [Related]

  • 14. Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole.
    Woodcroft KJ, Webb CD, Yao M, Weedon AC, Bend JR.
    Chem Res Toxicol; 1997 May 15; 10(5):589-99. PubMed ID: 9168258
    [Abstract] [Full Text] [Related]

  • 15. Mechanism of action of spironolactone on cortisol production by guinea pig adrenocortical cells.
    Rourke KA, Bergstrom JM, Larson IW, Colby HD.
    Mol Cell Endocrinol; 1991 Oct 15; 81(1-3):127-34. PubMed ID: 1797582
    [Abstract] [Full Text] [Related]

  • 16. Effects of cadmium in vitro on microsomal steroid metabolism in the inner and outer zones of the guinea pig adrenal cortex.
    Colby HD, Pope MR, Johnson PB, Sherry JH.
    J Biochem Toxicol; 1987 Oct 15; 2():1-11. PubMed ID: 3150009
    [Abstract] [Full Text] [Related]

  • 17. Comparative effects of cadmium, zinc, and lead in vitro on pulmonary, adrenal, and hepatic microsomal metabolism in the guinea pig.
    Colby HD, Johnson PB, Zulkoski JS, Pope MR, Miles PR.
    J Toxicol Environ Health; 1981 Oct 15; 8(5-6):907-15. PubMed ID: 7338951
    [Abstract] [Full Text] [Related]

  • 18. Identification of spironolactone metabolites in plasma and target organs of guinea pigs.
    Los LE, Coddington AB, Ramjit HG, Colby HD.
    Drug Metab Dispos; 1993 Oct 15; 21(6):1086-90. PubMed ID: 7905388
    [Abstract] [Full Text] [Related]

  • 19. Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite.
    Cook CS, Hauswald C, Oppermann JA, Schoenhard GL.
    J Pharmacol Exp Ther; 1993 Jul 15; 266(1):1-7. PubMed ID: 8331551
    [Abstract] [Full Text] [Related]

  • 20. In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.
    Tang J, Akao T, Nakamura N, Wang ZT, Takagawa K, Sasahara M, Hattori M.
    Drug Metab Dispos; 2007 Oct 15; 35(10):1832-9. PubMed ID: 17639025
    [Abstract] [Full Text] [Related]

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