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120 related items for PubMed ID: 4743908

  • 1. Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.
    Hill BT, Goldie JH, Price LA.
    Br J Cancer; 1973 Sep; 28(3):263-8. PubMed ID: 4743908
    [Abstract] [Full Text] [Related]

  • 2. Selective toxicity of a new lipophilic antifolate, BW301U, for methotrexate-resistant cells with reduced drug uptake.
    Taylor IW, Slowiaczek P, Friedlander ML, Tattersall MH.
    Cancer Res; 1985 Mar; 45(3):978-82. PubMed ID: 3971388
    [Abstract] [Full Text] [Related]

  • 3. In vitro screening of biochemical activity of folic acid antagonists in skin.
    McCullough JL, Weinstein GD, Hynes JB.
    J Invest Dermatol; 1977 Jun; 68(6):362-5. PubMed ID: 864277
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of dihydrofolate reductase and cell growth by antifolates in a methotrexate-resistant cell line.
    Hamrell MR.
    Oncology; 1984 Jun; 41(5):343-8. PubMed ID: 6540852
    [Abstract] [Full Text] [Related]

  • 5. Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
    Ohnoshi T, Ohnuma T, Takahashi I, Scanlon K, Kamen BA, Holland JF.
    Cancer Res; 1982 May; 42(5):1655-60. PubMed ID: 6978176
    [Abstract] [Full Text] [Related]

  • 6. Metabolic inhibition by a new antifolate, 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidine (BW3O1U), an effective inhibitor of human lymphoid and dihydrofolate reductase-overproducing mouse cell lines.
    Sedwick WD, Hamrell M, Brown OE, Laszlo J.
    Mol Pharmacol; 1982 Nov; 22(3):766-70. PubMed ID: 7155133
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of a methotrexate-insensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines.
    Dedhar S, Freisheim JH, Hynes JB, Goldie JH.
    Biochem Pharmacol; 1983 Mar 01; 32(5):922-4. PubMed ID: 6838639
    [Abstract] [Full Text] [Related]

  • 8. A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate.
    Selassie CD, Guo Z, Hansch C, Khwaja TA, Pentecost S.
    J Med Chem; 1982 Feb 01; 25(2):157-61. PubMed ID: 7057421
    [Abstract] [Full Text] [Related]

  • 9. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 01; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 10. Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate.
    Browman GP, Gorka C, Mehta C, Lazarus H, Abelson HT.
    Biochem Pharmacol; 1980 Aug 15; 29(16):2241-5. PubMed ID: 7426028
    [No Abstract] [Full Text] [Related]

  • 11. Pyrimethamin-resistant Plasmodium falciparum lack cross-resistance to methotrexate and 2,4-diamino-5-(substituted benzyl) pyrimidines.
    Walter RD, Bergmann B, Kansy M, Wiese M, Seydel JK.
    Parasitol Res; 1991 Aug 15; 77(4):346-50. PubMed ID: 1866423
    [Abstract] [Full Text] [Related]

  • 12. Dihydrofolate reductase activity in adriamycin and methotrexate sensitive and resistant P388 leukemia cells.
    Mandelbaum-Shavit F, Ramu A.
    Cell Biol Int Rep; 1987 May 15; 11(5):389-96. PubMed ID: 3607890
    [Abstract] [Full Text] [Related]

  • 13. New dose-time relationships of folate antagonists to sustain inhibition of human lymphoblasts and leukemic cells in vitro.
    Sedwick WD, Kutler M, Frazer T, Brown OE, Laszlo J.
    Cancer Res; 1979 Sep 15; 39(9):3612-8. PubMed ID: 314333
    [Abstract] [Full Text] [Related]

  • 14. In vitro inhibitory effects of polymer-linked methotrexate derivatives on tetrahydrofolate dehydrogenase and murine L5178Y cells.
    Fung WP, Przybylski M, Ringsdorf H, Zaharko DS.
    J Natl Cancer Inst; 1979 May 15; 62(5):1261-4. PubMed ID: 286102
    [Abstract] [Full Text] [Related]

  • 15. Much more than you expected: The non-DHFR-mediated effects of methotrexate.
    Sramek M, Neradil J, Veselska R.
    Biochim Biophys Acta Gen Subj; 2017 Mar 15; 1861(3):499-503. PubMed ID: 27993660
    [Abstract] [Full Text] [Related]

  • 16. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
    [Abstract] [Full Text] [Related]

  • 17. Transgenic mice expressing the tyr22 variant of murine DHFR: protection of transgenic marrow transplant recipients from lethal doses of methotrexate.
    James RI, May C, Vagt MD, Studebaker R, McIvor RS.
    Exp Hematol; 1997 Nov 15; 25(12):1286-95. PubMed ID: 9357973
    [Abstract] [Full Text] [Related]

  • 18. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct 15; 48(4):758-65. PubMed ID: 7476904
    [Abstract] [Full Text] [Related]

  • 19. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Jpn J Cancer Res; 1997 Sep 15; 88(9):900-6. PubMed ID: 9369939
    [Abstract] [Full Text] [Related]

  • 20. Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
    Selassie CD, Hansch C, Khwaja TA, Dias CB, Pentecost S.
    J Med Chem; 1984 Mar 15; 27(3):347-57. PubMed ID: 6699880
    [Abstract] [Full Text] [Related]

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