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Journal Abstract Search

146 related items for PubMed ID: 6220000

  • 1. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
    Bapat AR, Zarow C, Danenberg PV.
    J Biol Chem; 1983 Apr 10; 258(7):4130-6. PubMed ID: 6220000
    [Abstract] [Full Text] [Related]

  • 2. Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine.
    Davis ST, Berger SH.
    Mol Pharmacol; 1993 May 10; 43(5):702-8. PubMed ID: 8502227
    [Abstract] [Full Text] [Related]

  • 3. Resistance of CCRF-CEM cloned sublines to 5-fluorodeoxyuridine associated with enhanced phosphatase activities.
    Fernandes DJ, Cranford SK.
    Biochem Pharmacol; 1985 Jan 01; 34(1):125-32. PubMed ID: 3155614
    [Abstract] [Full Text] [Related]

  • 4. Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
    Zhang ZG, Malmberg M, Yin MB, Slocum HK, Rustum YM.
    Biochem Pharmacol; 1993 Mar 09; 45(5):1157-64. PubMed ID: 8461045
    [Abstract] [Full Text] [Related]

  • 5. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Jackman AL, Alison DL, Calvert AH, Harrap KR.
    Cancer Res; 1986 Jun 09; 46(6):2810-5. PubMed ID: 2938731
    [Abstract] [Full Text] [Related]

  • 6. Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis.
    Lockshin A, Danenberg PV.
    Biochemistry; 1980 Sep 02; 19(18):4244-51. PubMed ID: 6932226
    [Abstract] [Full Text] [Related]

  • 7. Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
    Hughey CT, Barbour KW, Berger FG, Berger SH.
    Mol Pharmacol; 1993 Aug 02; 44(2):316-23. PubMed ID: 8355668
    [Abstract] [Full Text] [Related]

  • 8. A method for the determination of total, free, and 5-fluorodeoxyuridylate-bound thymidylate synthase in cell extracts.
    Fernandes DJ, Cranford SK.
    Anal Biochem; 1984 Nov 01; 142(2):378-85. PubMed ID: 6241433
    [Abstract] [Full Text] [Related]

  • 9. Thymidylate synthetase purified to homogeneity from human leukemic cells.
    Lockshin A, Moran RG, Danenberg PV.
    Proc Natl Acad Sci U S A; 1979 Feb 01; 76(2):750-4. PubMed ID: 34155
    [Abstract] [Full Text] [Related]

  • 10. Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
    Fernandes DJ, Cranford SK.
    Cancer Res; 1986 Apr 01; 46(4 Pt 1):1741-7. PubMed ID: 2936450
    [Abstract] [Full Text] [Related]

  • 11. Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil.
    Washtien WL.
    Mol Pharmacol; 1984 Jan 01; 25(1):171-7. PubMed ID: 6708932
    [Abstract] [Full Text] [Related]

  • 12. Tight-binding complexes of thymidylate synthetase, folate analogs and deoxyribonucleotides.
    Danenberg PV, Lockshin A.
    Adv Enzyme Regul; 1982 Jan 01; 20():99-110. PubMed ID: 6810659
    [Abstract] [Full Text] [Related]

  • 13. Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase.
    Reilly RT, Forsthoefel AM, Berger FG.
    Arch Biochem Biophys; 1997 Jun 15; 342(2):338-43. PubMed ID: 9186496
    [Abstract] [Full Text] [Related]

  • 14. Mechanisms of resistance to fluoropyrimidines.
    Zhang ZG, Harstrick A, Rustum YM.
    Semin Oncol; 1992 Apr 15; 19(2 Suppl 3):4-9. PubMed ID: 1532673
    [Abstract] [Full Text] [Related]

  • 15. Effects of Mg2+ and adenine nucleotides on thymidylate synthetase from different mouse tumors.
    Rode W, Jastreboff MM.
    Mol Cell Biochem; 1984 Apr 15; 60(1):73-6. PubMed ID: 6231470
    [Abstract] [Full Text] [Related]

  • 16. Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate.
    Pellino AM, Danenberg PV.
    J Biol Chem; 1985 Sep 15; 260(20):10996-1000. PubMed ID: 3928628
    [Abstract] [Full Text] [Related]

  • 17. Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.
    Galivan JH, Maley GF, Maley F.
    Biochemistry; 1976 Jan 27; 15(2):356-62. PubMed ID: 813762
    [Abstract] [Full Text] [Related]

  • 18. Spectroscopic studies of ternary complexes of thymidylate synthetase, deoxyribonucleotides, and folate analogs.
    Lockshin A, Mondal K, Danenberg PV.
    J Biol Chem; 1984 Sep 25; 259(18):11346-52. PubMed ID: 6236224
    [Abstract] [Full Text] [Related]

  • 19. Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
    Boothman DA, Briggle TV, Greer S.
    Cancer Res; 1987 May 01; 47(9):2354-62. PubMed ID: 2952263
    [Abstract] [Full Text] [Related]

  • 20. Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
    Moran RG, Spears CP, Heidelberger C.
    Proc Natl Acad Sci U S A; 1979 Mar 01; 76(3):1456-60. PubMed ID: 108681
    [Abstract] [Full Text] [Related]

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