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774 related items for PubMed ID: 6225514

  • 1. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 2. Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.
    Mini E, Moroson BA, Franco CT, Bertino JR.
    Cancer Res; 1985 Jan; 45(1):325-30. PubMed ID: 3855284
    [Abstract] [Full Text] [Related]

  • 3. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y, Ohnuma T.
    Mt Sinai J Med; 1992 Oct; 59(5):419-24. PubMed ID: 1435841
    [Abstract] [Full Text] [Related]

  • 4. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Jpn J Cancer Res; 1997 Sep; 88(9):900-6. PubMed ID: 9369939
    [Abstract] [Full Text] [Related]

  • 5. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [Abstract] [Full Text] [Related]

  • 6. Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
    Ohnoshi T, Ohnuma T, Takahashi I, Scanlon K, Kamen BA, Holland JF.
    Cancer Res; 1982 May; 42(5):1655-60. PubMed ID: 6978176
    [Abstract] [Full Text] [Related]

  • 7. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Mauritz R, Bekkenk MW, Rots MG, Pieters R, Mini E, van Zantwijk CH, Veerman AJ, Peters GJ, Jansen G.
    Clin Cancer Res; 1998 Oct; 4(10):2399-410. PubMed ID: 9796971
    [Abstract] [Full Text] [Related]

  • 8. Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.
    Jansen G, Westerhof GR, Kathmann I, Rademaker BC, Rijksen G, Schornagel JH.
    Cancer Res; 1989 May 01; 49(9):2455-9. PubMed ID: 2706633
    [Abstract] [Full Text] [Related]

  • 9. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS, Galivan J, Wright JE, Rosowsky A.
    Mol Pharmacol; 1994 Apr 01; 45(4):783-91. PubMed ID: 7514264
    [Abstract] [Full Text] [Related]

  • 10. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
    McGuire JJ, Bergoltz VV, Heitzman KJ, Haile WH, Russell CA, Bolanowska WE, Kotake Y, Haneda T, Nomura H.
    Cancer Res; 1994 May 15; 54(10):2673-9. PubMed ID: 8168096
    [Abstract] [Full Text] [Related]

  • 11. Molecular mechanisms of resistance to antifolates, a review.
    Banerjee D, Ercikan-Abali E, Waltham M, Schnieders B, Hochhauser D, Li WW, Fan J, Gorlick R, Goker E, Bertino JR.
    Acta Biochim Pol; 1995 May 15; 42(4):457-64. PubMed ID: 8852336
    [Abstract] [Full Text] [Related]

  • 12. Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
    McGuire JJ, Magee KJ, Russell CA, Canestrari JM.
    Oncol Res; 1997 May 15; 9(3):139-47. PubMed ID: 9220499
    [Abstract] [Full Text] [Related]

  • 13. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 15; 5(9):2548-58. PubMed ID: 10499632
    [Abstract] [Full Text] [Related]

  • 14. Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
    Jansen G, Schornagel JH, Westerhof GR, Rijksen G, Newell DR, Jackman AL.
    Cancer Res; 1990 Dec 01; 50(23):7544-8. PubMed ID: 2253202
    [Abstract] [Full Text] [Related]

  • 15. Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.
    Pizzorno G, Moroson BA, Cashmore AR, Russello O, Mayer JR, Galivan J, Bunni MA, Priest DG, Beardsley GP.
    Cancer Res; 1995 Feb 01; 55(3):566-73. PubMed ID: 7834626
    [Abstract] [Full Text] [Related]

  • 16. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
    Li WW, Tong WP, Bertino JR.
    Clin Cancer Res; 1995 Jun 01; 1(6):631-6. PubMed ID: 9816025
    [Abstract] [Full Text] [Related]

  • 17. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
    McGuire JJ, Russell CA, Bolanowska WE, Freitag CM, Jones CS, Kalman TI.
    Cancer Res; 1990 Mar 15; 50(6):1726-31. PubMed ID: 2306727
    [Abstract] [Full Text] [Related]

  • 18. Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
    Galivan J, Nimec Z, Rhee M.
    Cancer Res; 1987 Oct 15; 47(20):5256-60. PubMed ID: 2958130
    [Abstract] [Full Text] [Related]

  • 19. Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
    Arkin H, Ohnuma T, Kamen BA, Holland JF, Vallabhajosula S.
    Cancer Res; 1989 Dec 01; 49(23):6556-61. PubMed ID: 2573416
    [Abstract] [Full Text] [Related]

  • 20. Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
    Sirotnak FM, Moccio DM, Goutas LJ, Kelleher LE, Montgomery JA.
    Cancer Res; 1982 Mar 01; 42(3):924-8. PubMed ID: 7059991
    [Abstract] [Full Text] [Related]

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