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374 related items for PubMed ID: 6324188

  • 1. Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.
    Nelson EM, Tewey KM, Liu LF.
    Proc Natl Acad Sci U S A; 1984 Mar; 81(5):1361-5. PubMed ID: 6324188
    [Abstract] [Full Text] [Related]

  • 2. Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage.
    Pommier Y, Minford JK, Schwartz RE, Zwelling LA, Kohn KW.
    Biochemistry; 1985 Nov 05; 24(23):6410-6. PubMed ID: 3002440
    [Abstract] [Full Text] [Related]

  • 3. Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.
    Covey JM, Kohn KW, Kerrigan D, Tilchen EJ, Pommier Y.
    Cancer Res; 1988 Feb 15; 48(4):860-5. PubMed ID: 2827887
    [Abstract] [Full Text] [Related]

  • 4. Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
    Tewey KM, Chen GL, Nelson EM, Liu LF.
    J Biol Chem; 1984 Jul 25; 259(14):9182-7. PubMed ID: 6086625
    [Abstract] [Full Text] [Related]

  • 5. DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.
    Rowe TC, Chen GL, Hsiang YH, Liu LF.
    Cancer Res; 1986 Apr 25; 46(4 Pt 2):2021-6. PubMed ID: 3004716
    [Abstract] [Full Text] [Related]

  • 6. Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei.
    Pommier Y, Schwartz RE, Zwelling LA, Kohn KW.
    Biochemistry; 1985 Nov 05; 24(23):6406-10. PubMed ID: 3002439
    [Abstract] [Full Text] [Related]

  • 7. Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin.
    Zwelling LA, Michaels S, Erickson LC, Ungerleider RS, Nichols M, Kohn KW.
    Biochemistry; 1981 Nov 10; 20(23):6553-63. PubMed ID: 6895473
    [Abstract] [Full Text] [Related]

  • 8. Effect of 1-beta-D-arabinofuranosylcytosine (ara-C) on nuclear topoisomerase II activity and on the DNA cleavage and cytotoxicity produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) and etoposide in m-AMSA-sensitive and -resistant human leukemia cells.
    Bakic M, Chan D, Andersson BS, Beran M, Silberman L, Estey E, Ricketts L, Zwelling LA.
    Biochem Pharmacol; 1987 Dec 01; 36(23):4067-77. PubMed ID: 2825713
    [Abstract] [Full Text] [Related]

  • 9. Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
    Robinson MJ, Osheroff N.
    Biochemistry; 1990 Mar 13; 29(10):2511-5. PubMed ID: 2159323
    [Abstract] [Full Text] [Related]

  • 10. The production of topoisomerase II-mediated DNA cleavage in human leukemia cells predicts their susceptibility to 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA).
    Bakic M, Beran M, Andersson BS, Silberman L, Estey E, Zwelling LA.
    Biochem Biophys Res Commun; 1986 Jan 29; 134(2):638-45. PubMed ID: 3004458
    [Abstract] [Full Text] [Related]

  • 11. Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli.
    Huff AC, Leatherwood JK, Kreuzer KN.
    Proc Natl Acad Sci U S A; 1989 Feb 29; 86(4):1307-11. PubMed ID: 2537494
    [Abstract] [Full Text] [Related]

  • 12. Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.
    Pommier Y, Covey J, Kerrigan D, Mattes W, Markovits J, Kohn KW.
    Biochem Pharmacol; 1987 Oct 15; 36(20):3477-86. PubMed ID: 2823823
    [Abstract] [Full Text] [Related]

  • 13. Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol.
    Adlakha RC, Ashorn CL, Chan D, Zwelling LA.
    Cancer Res; 1989 Apr 15; 49(8):2052-8. PubMed ID: 2539251
    [Abstract] [Full Text] [Related]

  • 14. Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials.
    Poddevin B, Riou JF, Lavelle F, Pommier Y.
    Mol Pharmacol; 1993 Oct 15; 44(4):767-74. PubMed ID: 8232227
    [Abstract] [Full Text] [Related]

  • 15. Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4'-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage.
    Jensen PB, Sørensen BS, Demant EJ, Sehested M, Jensen PS, Vindeløv L, Hansen HH.
    Cancer Res; 1990 Jun 01; 50(11):3311-6. PubMed ID: 2159380
    [Abstract] [Full Text] [Related]

  • 16. Effect of difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the topoisomerase II-mediated DNA scission produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide in L1210 murine leukemia cells.
    Zwelling LA, Kerrigan D, Marton LJ.
    Cancer Res; 1985 Mar 01; 45(3):1122-6. PubMed ID: 2982483
    [Abstract] [Full Text] [Related]

  • 17. Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.
    Ketron AC, Denny WA, Graves DE, Osheroff N.
    Biochemistry; 2012 Feb 28; 51(8):1730-9. PubMed ID: 22304499
    [Abstract] [Full Text] [Related]

  • 18. In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin.
    Yang L, Rowe TC, Nelson EM, Liu LF.
    Cell; 1985 May 28; 41(1):127-32. PubMed ID: 2986841
    [Abstract] [Full Text] [Related]

  • 19. Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.
    Pommier Y, Zwelling LA, Kao-Shan CS, Whang-Peng J, Bradley MO.
    Cancer Res; 1985 Jul 28; 45(7):3143-9. PubMed ID: 2988762
    [Abstract] [Full Text] [Related]

  • 20. Evidence for a common mechanism of action for antitumor and antibacterial agents that inhibit type II DNA topoisomerases.
    Huff AC, Kreuzer KN.
    J Biol Chem; 1990 Nov 25; 265(33):20496-505. PubMed ID: 2173709
    [Abstract] [Full Text] [Related]

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