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Journal Abstract Search

99 related items for PubMed ID: 6470960

  • 1. Relationship between molecular structure and cytochrome P450-metabolic intermediate complex formation, studied with orphenadrine analogues.
    Bast A, Savenije-Chapel EM, Noordhoek J.
    J Pharm Sci; 1984 Jul; 73(7):953-6. PubMed ID: 6470960
    [Abstract] [Full Text] [Related]

  • 2. Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the rat.
    Bast A, van Kemenade FA, Savenije-Chapel EM, Noordhoek J.
    Res Commun Chem Pathol Pharmacol; 1983 Jun; 40(3):391-403. PubMed ID: 6622816
    [Abstract] [Full Text] [Related]

  • 3. Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes.
    Roos PH, Mahnke A.
    Biochem Pharmacol; 1996 Jul 12; 52(1):73-84. PubMed ID: 8678911
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of oxidative drug metabolism by orphenadrine: in vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics.
    Reidy GF, Mehta I, Murray M.
    Mol Pharmacol; 1989 May 12; 35(5):736-43. PubMed ID: 2725477
    [Abstract] [Full Text] [Related]

  • 5. Cytochrome P450 metabolic intermediate complex of nefopam.
    Leurs R, Donnell D, Timmerman H, Bast A.
    J Pharm Pharmacol; 1987 Oct 12; 39(10):835-7. PubMed ID: 2891822
    [Abstract] [Full Text] [Related]

  • 6. Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat.
    Bast A, Noordhoek J.
    Biochem Pharmacol; 1982 Sep 01; 31(17):2745-53. PubMed ID: 7138571
    [No Abstract] [Full Text] [Related]

  • 7. Evidence for complexation of P-450 IIC6 by an orphenadrine metabolite.
    Reidy GF, Murray M.
    Biochem Biophys Res Commun; 1990 Jan 30; 166(2):772-9. PubMed ID: 2302238
    [Abstract] [Full Text] [Related]

  • 8. Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat.
    Bast A, Savenije-Chapel EM, van Kemenade FA, Scheefhals LW, Noordhoek J.
    Arch Toxicol; 1983 Oct 30; 54(2):131-7. PubMed ID: 6651526
    [Abstract] [Full Text] [Related]

  • 9. Cytochrome P-450 metabolic-intermediate complex formation with a series of diphenhydramine analogues.
    Bast A, Valk AJ, Timmerman H.
    Agents Actions; 1990 Apr 30; 30(1-2):161-5. PubMed ID: 2371918
    [Abstract] [Full Text] [Related]

  • 10. Common multiple interactions of tricyclic anti-depressants and orphenadrine with liver microsomal cytochrome P450 enzymes of the rat.
    Roos PH.
    Xenobiotica; 1999 Jun 30; 29(6):629-40. PubMed ID: 10426561
    [Abstract] [Full Text] [Related]

  • 11. Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline.
    Murray M.
    Mol Pharmacol; 1992 Nov 30; 42(5):931-8. PubMed ID: 1435757
    [Abstract] [Full Text] [Related]

  • 12. Interaction of nefopam and orphenadrine with the cytochrome P-450 and the glutathione system in rat liver.
    Leurs R, Donnell D, Timmerman H, Bast A.
    J Pharm Pharmacol; 1989 Jun 30; 41(6):388-93. PubMed ID: 2570834
    [Abstract] [Full Text] [Related]

  • 13. Dependence of hydrogen peroxide formation in rat liver microsomes on the molecular structure of cytochrome P-450 substrates: a study with barbiturates and beta-adrenoceptor antagonists.
    Bast A, Goossens PA, Savenije-Chapel EM.
    Eur J Drug Metab Pharmacokinet; 1989 Jun 30; 14(2):93-100. PubMed ID: 2574109
    [Abstract] [Full Text] [Related]

  • 14. Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. 8. Stereoselectivity in metabolic intermediary complex formation with a series of chiral 2-substituted 1-phenyl-2-aminoethanes.
    Paulsen-Sörman UB, Jönsson KH, Lindeke BG.
    J Med Chem; 1984 Mar 30; 27(3):342-6. PubMed ID: 6699879
    [Abstract] [Full Text] [Related]

  • 15. Complexes of cytochrome P450 with metyrapone. A convenient method for the quantitative analysis of phenobarbital-inducible cytochrome P450 in rat liver microsomes.
    Mitani F, Shephard EA, Phillips IR, Rabin BR.
    FEBS Lett; 1982 Nov 08; 148(2):302-6. PubMed ID: 7152025
    [Abstract] [Full Text] [Related]

  • 16. Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers.
    Lindstrom TD, Hanssen BR, Wrighton SA.
    Antimicrob Agents Chemother; 1993 Feb 08; 37(2):265-9. PubMed ID: 8452357
    [Abstract] [Full Text] [Related]

  • 17. Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-,N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine.
    Shu L, Hollenberg PF.
    Carcinogenesis; 1996 Apr 08; 17(4):839-48. PubMed ID: 8625499
    [Abstract] [Full Text] [Related]

  • 18. Enhanced rates of cytochrome P450 metabolic-intermediate complex formation from nonmacrolide amines in rifampicin-treated rabbit liver microsomes.
    Franklin MR.
    Drug Metab Dispos; 1995 Dec 08; 23(12):1379-82. PubMed ID: 8689947
    [Abstract] [Full Text] [Related]

  • 19. Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine.
    Riddick DS, Marks GS.
    Biochem Pharmacol; 1990 Oct 15; 40(8):1915-21. PubMed ID: 2242024
    [Abstract] [Full Text] [Related]

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