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Journal Abstract Search

237 related items for PubMed ID: 648118

  • 1. Pharmacologic considerations in the design of toxicology experiments.
    Darby TD.
    Clin Toxicol; 1978 Feb; 12(2):229-38. PubMed ID: 648118
    [Abstract] [Full Text] [Related]

  • 2. Future of toxicology--low-dose toxicology and risk--benefit analysis.
    Rietjens IM, Alink GM.
    Chem Res Toxicol; 2006 Aug; 19(8):977-81. PubMed ID: 16918235
    [Abstract] [Full Text] [Related]

  • 3. The use of pharmacokinetics as an interpretive and predictive tool in chemical toxicology testing and risk assessment: a position paper on the appropriate use of pharmacokinetics in chemical toxicology.
    Frantz SW, Beatty PW, English JC, Hundley SG, Wilson AG.
    Regul Toxicol Pharmacol; 1994 Jun; 19(3):317-37. PubMed ID: 8090955
    [Abstract] [Full Text] [Related]

  • 4. On setting the first dose in man: quantitating biotherapeutic drug-target binding through pharmacokinetic and pharmacodynamic models.
    Lowe PJ, Tannenbaum S, Wu K, Lloyd P, Sims J.
    Basic Clin Pharmacol Toxicol; 2010 Mar; 106(3):195-209. PubMed ID: 20050847
    [Abstract] [Full Text] [Related]

  • 5. In silico toxicology for the pharmaceutical sciences.
    Valerio LG.
    Toxicol Appl Pharmacol; 2009 Dec 15; 241(3):356-70. PubMed ID: 19716836
    [Abstract] [Full Text] [Related]

  • 6. Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations.
    Gabrielsson J, Dolgos H, Gillberg PG, Bredberg U, Benthem B, Duker G.
    Drug Discov Today; 2009 Apr 15; 14(7-8):358-72. PubMed ID: 19162219
    [Abstract] [Full Text] [Related]

  • 7. Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery - the GSK experience.
    Vanderwall DE, Yuen N, Al-Ansari M, Bailey J, Fram D, Green DV, Pickett S, Vitulli G, Luengo JI, Almenoff JS.
    Drug Discov Today; 2011 Aug 15; 16(15-16):646-53. PubMed ID: 21601652
    [Abstract] [Full Text] [Related]

  • 8. Nonlinear pharmacokinetics relative to toxicity and use of toxicological data.
    Ramsey JC.
    Drug Metab Rev; 1982 Aug 15; 13(5):779-97. PubMed ID: 6754308
    [No Abstract] [Full Text] [Related]

  • 9. Safety pharmacology: an essential interface of pharmacology and toxicology in the non-clinical assessment of new pharmaceuticals.
    Claude JR, Claude N.
    Toxicol Lett; 2004 Jun 15; 151(1):25-8. PubMed ID: 15177637
    [Abstract] [Full Text] [Related]

  • 10. Pharmacokinetic considerations in toxicity testing.
    Jollow DJ, Roberts S, Price V, Longacre S, Smith C.
    Drug Metab Rev; 1982 Jun 15; 13(6):983-1007. PubMed ID: 6754320
    [No Abstract] [Full Text] [Related]

  • 11. The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinical trials with monoclonal antibodies.
    Muller PY, Milton M, Lloyd P, Sims J, Brennan FR.
    Curr Opin Biotechnol; 2009 Dec 15; 20(6):722-9. PubMed ID: 19896825
    [Abstract] [Full Text] [Related]

  • 12. Considerations in chronic toxicity testing: the chemical, the dose, the design.
    Munro IC.
    J Environ Pathol Toxicol; 1977 Dec 15; 1(2):183-97. PubMed ID: 553130
    [Abstract] [Full Text] [Related]

  • 13. Assessment of the safety of drugs for animals.
    Robens JF.
    Vet Hum Toxicol; 1979 Feb 15; 21(1):12-23. PubMed ID: 425289
    [Abstract] [Full Text] [Related]

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  • 15. Safety assessment of drug residues.
    Jackson BA.
    J Am Vet Med Assoc; 1980 May 15; 176(10 Spec No):1141-4. PubMed ID: 6894293
    [Abstract] [Full Text] [Related]

  • 16.
    ; . PubMed ID:
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  • 17. In silico methods for early toxicity assessment.
    Merlot C.
    Curr Opin Drug Discov Devel; 2008 Jan 15; 11(1):80-5. PubMed ID: 18175270
    [Abstract] [Full Text] [Related]

  • 18. Methodological innovations expand the safety pharmacology horizon.
    Pugsley MK, Curtis MJ.
    J Pharmacol Toxicol Methods; 2012 Sep 15; 66(2):59-62. PubMed ID: 22617368
    [Abstract] [Full Text] [Related]

  • 19. Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences.
    Calabrese EJ.
    Environ Pollut; 2005 Dec 15; 138(3):379-411. PubMed ID: 16098930
    [Abstract] [Full Text] [Related]

  • 20. Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation.
    Chapman KL, Holzgrefe H, Black LE, Brown M, Chellman G, Copeman C, Couch J, Creton S, Gehen S, Hoberman A, Kinter LB, Madden S, Mattis C, Stemple HA, Wilson S.
    Regul Toxicol Pharmacol; 2013 Jun 15; 66(1):88-103. PubMed ID: 23524271
    [Abstract] [Full Text] [Related]

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