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Journal Abstract Search

146 related items for PubMed ID: 6699880

  • 1. Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
    Selassie CD, Hansch C, Khwaja TA, Dias CB, Pentecost S.
    J Med Chem; 1984 Mar; 27(3):347-57. PubMed ID: 6699880
    [Abstract] [Full Text] [Related]

  • 2. A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate.
    Selassie CD, Guo Z, Hansch C, Khwaja TA, Pentecost S.
    J Med Chem; 1982 Feb; 25(2):157-61. PubMed ID: 7057421
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of a methotrexate-insensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines.
    Dedhar S, Freisheim JH, Hynes JB, Goldie JH.
    Biochem Pharmacol; 1983 Mar 01; 32(5):922-4. PubMed ID: 6838639
    [Abstract] [Full Text] [Related]

  • 4. Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
    Coats EA, Genther CS, Selassie CD, Strong CD, Hansch C.
    J Med Chem; 1985 Dec 01; 28(12):1910-6. PubMed ID: 3934385
    [Abstract] [Full Text] [Related]

  • 5. Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate.
    Selassie CD, Strong CD, Hansch C, Delcamp TJ, Freisheim JH, Khwaja TA.
    Cancer Res; 1986 Feb 01; 46(2):744-56. PubMed ID: 3940640
    [Abstract] [Full Text] [Related]

  • 6. Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
    Selassie CD, Li R, Hansch C, Khwaja TA, Dias CB.
    J Med Chem; 1982 May 01; 25(5):518-22. PubMed ID: 7086836
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.
    Hathaway BA, Guo ZR, Hansch C, Delcamp TJ, Susten SS, Freisheim JH.
    J Med Chem; 1984 Feb 01; 27(2):144-9. PubMed ID: 6694162
    [Abstract] [Full Text] [Related]

  • 8. Further studies on substituted quinazolines and triazines as inhibitors of a methotrexate-insensitive murine dihydrofolate reductase.
    Dedhar S, Freisheim JH, Hynes JB, Goldie JH.
    Biochem Pharmacol; 1986 Apr 01; 35(7):1143-7. PubMed ID: 3964294
    [Abstract] [Full Text] [Related]

  • 9. Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in making inferences about the mechanism of resistance and the structure of the enzyme is situ compared with the enzyme in vitro.
    Coats EA, Genther CS, Dietrich SW, Guo ZR, Hansch C.
    J Med Chem; 1981 Dec 01; 24(12):1422-9. PubMed ID: 6796688
    [Abstract] [Full Text] [Related]

  • 10. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Mauritz R, Bekkenk MW, Rots MG, Pieters R, Mini E, van Zantwijk CH, Veerman AJ, Peters GJ, Jansen G.
    Clin Cancer Res; 1998 Oct 01; 4(10):2399-410. PubMed ID: 9796971
    [Abstract] [Full Text] [Related]

  • 11. Dihydrofolate reductase inhibition. A study in the use of X-ray crystallography, molecular graphics, and quantitative structure-activity relations in drug design.
    Hansch C.
    Drug Intell Clin Pharm; 1982 May 01; 16(5):391-6. PubMed ID: 6806055
    [Abstract] [Full Text] [Related]

  • 12. Characterization by flow cytometry and fluorescein-methotrexate labeling of hydrophilic and lipophilic antifolate resistance in cultured mammalian cells.
    Assaraf YG.
    Anticancer Drugs; 1993 Oct 01; 4(5):535-44. PubMed ID: 8292810
    [Abstract] [Full Text] [Related]

  • 13. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 01; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 14. Comparison of quantitative structure-activity relationships of the inhibition of leukemia cells in culture with the inhibition of dihydrofolate reductase from leukemia cells and other cell types.
    Khwaja TA, Pentecost S, Selassie CD, Guo Z, Hansch C.
    J Med Chem; 1982 Feb 01; 25(2):153-6. PubMed ID: 7057420
    [Abstract] [Full Text] [Related]

  • 15. A comparison of the inhibition of bovine and murine leukemia dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazines.
    Guo ZR, Dietrich SW, Hansch C, Dolnick BJ, Bertino JR.
    Mol Pharmacol; 1981 Nov 01; 20(3):649-56. PubMed ID: 7329407
    [No Abstract] [Full Text] [Related]

  • 16. Biological and biochemical properties of new anticancer folate antagonists.
    Fry DW, Jackson RC.
    Cancer Metastasis Rev; 1987 Nov 01; 5(3):251-70. PubMed ID: 3549036
    [Abstract] [Full Text] [Related]

  • 17. Conformational analysis of lipophilic antifolates: crystal and molecular structures of three s-triazine dihydrofolate reductase inhibitors.
    Cody V, Sutton PA.
    Anticancer Drug Des; 1987 Dec 01; 2(3):253-62. PubMed ID: 3449089
    [Abstract] [Full Text] [Related]

  • 18. Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
    Ohnoshi T, Ohnuma T, Takahashi I, Scanlon K, Kamen BA, Holland JF.
    Cancer Res; 1982 May 01; 42(5):1655-60. PubMed ID: 6978176
    [Abstract] [Full Text] [Related]

  • 19. Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
    Piper JR, Johnson CA, Maddry JA, Malik ND, McGuire JJ, Otter GM, Sirotnak FM.
    J Med Chem; 1993 Dec 24; 36(26):4161-71. PubMed ID: 8277497
    [Abstract] [Full Text] [Related]

  • 20. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
    Rosowsky A, Bader H, Kohler W, Freisheim JH, Moran RG.
    J Med Chem; 1988 Jul 24; 31(7):1338-44. PubMed ID: 2898531
    [Abstract] [Full Text] [Related]

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