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243 related items for PubMed ID: 6733364

  • 1. Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle erythrocytes.
    Beddell CR, Goodford PJ, Kneen G, White RD, Wilkinson S, Wootton R.
    Br J Pharmacol; 1984 Jun; 82(2):397-407. PubMed ID: 6733364
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  • 3. Pharmacological modification of oxygen affinity improves deformability of deoxygenated sickle erythrocytes: a possible therapeutic approach to sickle cell disease.
    Keidan AJ, Sowter MC, Johnson CS, Marwah SS, Stuart J.
    Clin Sci (Lond); 1989 Apr; 76(4):357-62. PubMed ID: 2714049
    [Abstract] [Full Text] [Related]

  • 4. New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?
    Oder E, Safo MK, Abdulmalik O, Kato GJ.
    Br J Haematol; 2016 Oct; 175(1):24-30. PubMed ID: 27605087
    [Abstract] [Full Text] [Related]

  • 5. An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling.
    Omar AM, Abdulmalik O, Ghatge MS, Muhammad YA, Paredes SD, El-Araby ME, Safo MK.
    Biomolecules; 2020 Nov 02; 10(11):. PubMed ID: 33147875
    [Abstract] [Full Text] [Related]

  • 6. Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation.
    Jensen M, Bunn HF, Halikas G, Kan YW, Nathan DG.
    J Clin Invest; 1973 Oct 02; 52(10):2542-7. PubMed ID: 4729047
    [Abstract] [Full Text] [Related]

  • 7. Pyridyl derivatives of benzaldehyde as potential antisickling agents.
    Nnamani IN, Joshi GS, Danso-Danquah R, Abdulmalik O, Asakura T, Abraham DJ, Safo MK.
    Chem Biodivers; 2008 Sep 02; 5(9):1762-9. PubMed ID: 18816529
    [Abstract] [Full Text] [Related]

  • 8. Effects of carbon dioxide and pH variations in vitro on blood respiratory functions, red blood cell volume, transmembrane pH gradients, and sickling in sickle cell anemia.
    Ueda Y, Bookchin RM.
    J Lab Clin Med; 1984 Aug 02; 104(2):146-59. PubMed ID: 6431043
    [Abstract] [Full Text] [Related]

  • 9. 5'-deoxypyridoxal as a potential anti-sickling agent.
    Benesch R, Benesch RE, Edalji R, Suzuki T.
    Proc Natl Acad Sci U S A; 1977 Apr 02; 74(4):1721-3. PubMed ID: 266212
    [Abstract] [Full Text] [Related]

  • 10. Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
    Henry ER, Metaferia B, Li Q, Harper J, Best RB, Glass KE, Cellmer T, Dunkelberger EB, Conrey A, Thein SL, Bunn HF, Eaton WA.
    Blood; 2021 Sep 30; 138(13):1172-1181. PubMed ID: 34197597
    [Abstract] [Full Text] [Related]

  • 11. The effects in volunteers of BW12C, a compound designed to left-shift the blood-oxygen saturation curve.
    Fitzharris P, McLean AE, Sparks RG, Weatherley BC, White RD, Wootton R.
    Br J Clin Pharmacol; 1985 Apr 30; 19(4):471-81. PubMed ID: 3994894
    [Abstract] [Full Text] [Related]

  • 12. Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.
    Pagare PP, Ghatge MS, Musayev FN, Deshpande TM, Chen Q, Braxton C, Kim S, Venitz J, Zhang Y, Abdulmalik O, Safo MK.
    Bioorg Med Chem; 2018 May 15; 26(9):2530-2538. PubMed ID: 29655608
    [Abstract] [Full Text] [Related]

  • 13. Abnormal haemoglobin electrophoresis caused by BW 12C.
    van Rhee F, Ware I, Littlewood T.
    J Clin Pathol; 1992 Oct 15; 45(10):930. PubMed ID: 1430268
    [Abstract] [Full Text] [Related]

  • 14. Sickling as a function of oxygen delivery: effect of simulated transfusions of stored, fresh and inositol-hexaphosphate-loaded (low affinity) red cells.
    Kumpati J, Franco RS, Weiner M, Martelo OJ.
    Blood Cells; 1982 Oct 15; 8(2):263-72. PubMed ID: 7159750
    [Abstract] [Full Text] [Related]

  • 15. Effect of BW12C on oxygen affinity of haemoglobin in sickle-cell disease.
    Keidan AJ, Franklin IM, White RD, Joy M, Huehns ER, Stuart J.
    Lancet; 1986 Apr 12; 1(8485):831-4. PubMed ID: 2870317
    [Abstract] [Full Text] [Related]

  • 16. Preservation of deformability (filterability) of sickle cells by BW12C during progressive deoxygenation.
    Kenny MW, Stuart J.
    Br J Haematol; 1983 Nov 12; 55(3):465-71. PubMed ID: 6639888
    [Abstract] [Full Text] [Related]

  • 17. The effect of 2,3-diphosphoglycerate on the oxygen dissociation curve of human haemoglobin.
    Goodford PJ, Norrington FE, Paterson RA, Wootton R.
    J Physiol; 1977 Dec 12; 273(3):631-45. PubMed ID: 604451
    [Abstract] [Full Text] [Related]

  • 18. Increasing haemoglobin oxygen affinity to prevent sickling: abnormal haemoglobin variants as models.
    Franklin IM, Huehns ER, Rosemeyer MA.
    Br J Haematol; 1986 Oct 12; 64(2):319-29. PubMed ID: 3778826
    [Abstract] [Full Text] [Related]

  • 19. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
    Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR.
    Br J Haematol; 2016 Oct 12; 175(1):141-53. PubMed ID: 27378309
    [Abstract] [Full Text] [Related]

  • 20. Recombinant human hemoglobins designed for gene therapy of sickle cell disease.
    McCune SL, Reilly MP, Chomo MJ, Asakura T, Townes TM.
    Proc Natl Acad Sci U S A; 1994 Oct 11; 91(21):9852-6. PubMed ID: 7937904
    [Abstract] [Full Text] [Related]

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