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Journal Abstract Search

114 related items for PubMed ID: 6806055

  • 1. Dihydrofolate reductase inhibition. A study in the use of X-ray crystallography, molecular graphics, and quantitative structure-activity relations in drug design.
    Hansch C.
    Drug Intell Clin Pharm; 1982 May; 16(5):391-6. PubMed ID: 6806055
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  • 2. A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate.
    Selassie CD, Guo Z, Hansch C, Khwaja TA, Pentecost S.
    J Med Chem; 1982 Feb; 25(2):157-61. PubMed ID: 7057421
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  • 3. Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis.
    Hansch C, Li R, Blaney JM, Langridge R.
    J Med Chem; 1982 Jul; 25(7):777-84. PubMed ID: 6809941
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  • 4. Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
    Hansch C, Hathaway BA, Guo ZR, Selassie CD, Dietrich SW, Blaney JM, Langridge R, Volz KW, Kaufman BT.
    J Med Chem; 1984 Feb; 27(2):129-43. PubMed ID: 6420569
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  • 5. On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
    Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT.
    J Med Chem; 1989 Aug; 32(8):1895-905. PubMed ID: 2502631
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  • 6. Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in making inferences about the mechanism of resistance and the structure of the enzyme is situ compared with the enzyme in vitro.
    Coats EA, Genther CS, Dietrich SW, Guo ZR, Hansch C.
    J Med Chem; 1981 Dec; 24(12):1422-9. PubMed ID: 6796688
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  • 10. Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
    Selassie CD, Hansch C, Khwaja TA, Dias CB, Pentecost S.
    J Med Chem; 1984 Mar; 27(3):347-57. PubMed ID: 6699880
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  • 11. On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
    Selassie CD, Li RL, Poe M, Hansch C.
    J Med Chem; 1991 Jan; 34(1):46-54. PubMed ID: 1899453
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  • 12. Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.
    Booth RG, Selassie CD, Hansch C, Santi DV.
    J Med Chem; 1987 Jul; 30(7):1218-24. PubMed ID: 3599028
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  • 13. Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.
    Marlowe CK, Selassie CD, Santi DV.
    J Med Chem; 1995 Mar 17; 38(6):967-72. PubMed ID: 7699713
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  • 14. A comparison of the inhibition of bovine and murine leukemia dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazines.
    Guo ZR, Dietrich SW, Hansch C, Dolnick BJ, Bertino JR.
    Mol Pharmacol; 1981 Nov 17; 20(3):649-56. PubMed ID: 7329407
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  • 18. Inhibition of dihydrofolate reductase: structure-activity correlations of 2,4-diamino-5-benzylpyrimidines based upon molecular shape analysis.
    Hopfinger AJ.
    J Med Chem; 1981 Jul 17; 24(7):818-22. PubMed ID: 7277386
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  • 19. Quantitative structure-activity relationships by neural networks and inductive logic programming. II. The inhibition of dihydrofolate reductase by triazines.
    Hirst JD, King RD, Sternberg MJ.
    J Comput Aided Mol Des; 1994 Aug 17; 8(4):421-32. PubMed ID: 7815093
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  • 20. Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.
    Srinivasan B, Tonddast-Navaei S, Skolnick J.
    Eur J Med Chem; 2015 Oct 20; 103():600-14. PubMed ID: 26414808
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