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Journal Abstract Search

125 related items for PubMed ID: 7277386

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  • 24. On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
    Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT.
    J Med Chem; 1989 Aug; 32(8):1895-905. PubMed ID: 2502631
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  • 27. Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
    Hansch C, Hathaway BA, Guo ZR, Selassie CD, Dietrich SW, Blaney JM, Langridge R, Volz KW, Kaufman BT.
    J Med Chem; 1984 Feb; 27(2):129-43. PubMed ID: 6420569
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  • 28. Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase.
    Wang M, Yang J, Yuan M, Xue L, Li H, Tian C, Wang X, Liu J, Zhang Z.
    Eur J Med Chem; 2017 Mar 10; 128():88-97. PubMed ID: 28152430
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  • 36. 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 10. 2,4-Diamino-5-(6-quinolylmethyl)- and -[(tetrahydro-6-quinolyl)methyl]pyrimidine derivatives. Further specificity studies.
    Rauckman BS, Tidwell MY, Johnson JV, Roth B.
    J Med Chem; 1989 Aug 10; 32(8):1927-35. PubMed ID: 2502632
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  • 37. Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
    Gangjee A, Shi J, Queener SF, Barrows LR, Kisliuk RL.
    J Med Chem; 1993 Oct 29; 36(22):3437-43. PubMed ID: 8230134
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  • 38. Quantitative structure-activity relationship by distance geometry: quinazolines as dihydrofolate reductase inhibitors.
    Ghose AK, Crippen GM.
    J Med Chem; 1982 Aug 29; 25(8):892-9. PubMed ID: 7120278
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  • 39. Dihydrofolate reductase inhibition. A study in the use of X-ray crystallography, molecular graphics, and quantitative structure-activity relations in drug design.
    Hansch C.
    Drug Intell Clin Pharm; 1982 May 29; 16(5):391-6. PubMed ID: 6806055
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