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107 related items for PubMed ID: 7488240

  • 21. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
    Siegel D, Gibson NW, Preusch PC, Ross D.
    Cancer Res; 1990 Dec 01; 50(23):7483-9. PubMed ID: 1701346
    [Abstract] [Full Text] [Related]

  • 22. Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
    Palom Y, Belcourt MF, Kumar GS, Arai H, Kasai M, Sartorelli AC, Rockwell S, Tomasz M.
    Oncol Res; 1998 Dec 01; 10(10):509-21. PubMed ID: 10338154
    [Abstract] [Full Text] [Related]

  • 23. Increased sensitivity of quinone resistant cells to mitomycin C.
    Begleiter A, Robotham E, Lacey G, Leith MK.
    Cancer Lett; 1989 Jun 01; 45(3):173-6. PubMed ID: 2471583
    [Abstract] [Full Text] [Related]

  • 24. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 01; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

  • 25. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.
    Begleiter A, Robotham E, Leith MK.
    Mol Pharmacol; 1992 Apr 01; 41(4):677-82. PubMed ID: 1373799
    [Abstract] [Full Text] [Related]

  • 26. The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    J Biol Chem; 1998 Apr 10; 273(15):8875-81. PubMed ID: 9535868
    [Abstract] [Full Text] [Related]

  • 27. Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.
    Palom Y, Belcourt MF, Tang LQ, Mehta SS, Sartorelli AC, Pritsos CA, Pritsos KL, Rockwell S, Tomasz M.
    Biochem Pharmacol; 2001 Jun 15; 61(12):1517-29. PubMed ID: 11377381
    [Abstract] [Full Text] [Related]

  • 28. Modulation of the antineoplastic efficacy of mitomycin C by dicoumarol in vivo.
    Rockwell S, Keyes SR, Sartorelli AC.
    Cancer Chemother Pharmacol; 1989 Jun 15; 24(6):349-53. PubMed ID: 2477164
    [Abstract] [Full Text] [Related]

  • 29. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions.
    Begleiter A, Leith MK.
    Mol Pharmacol; 1993 Jul 15; 44(1):210-5. PubMed ID: 8341273
    [Abstract] [Full Text] [Related]

  • 30. Modulation of the cytotoxicity of porfiromycin by dicoumarol in vitro and in vivo.
    Rockwell S, Keyes SR, Sartorelli AC.
    Anticancer Res; 1989 Jul 15; 9(4):817-20. PubMed ID: 2479329
    [Abstract] [Full Text] [Related]

  • 31. Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions.
    Seow HA, Penketh PG, Belcourt MF, Tomasz M, Rockwell S, Sartorelli AC.
    J Biol Chem; 2004 Jul 23; 279(30):31606-12. PubMed ID: 15155746
    [Abstract] [Full Text] [Related]

  • 32. Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
    Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC.
    Cancer Res; 2001 Nov 01; 61(21):7770-6. PubMed ID: 11691791
    [Abstract] [Full Text] [Related]

  • 33. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 1996 Jan 09; 93(1):456-60. PubMed ID: 8552660
    [Abstract] [Full Text] [Related]

  • 34. Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
    Seow HA, Belcourt MF, Penketh PG, Hodnick WF, Tomasz M, Rockwell S, Sartorelli AC.
    Mol Pharmacol; 2005 Feb 09; 67(2):417-23. PubMed ID: 15547247
    [Abstract] [Full Text] [Related]

  • 35. Effect of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro.
    Rockwell S.
    Int J Cancer; 1986 Aug 15; 38(2):229-35. PubMed ID: 3089943
    [Abstract] [Full Text] [Related]

  • 36. Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics.
    Pritsos CA, Sartorelli AC.
    Cancer Res; 1986 Jul 15; 46(7):3528-32. PubMed ID: 3011250
    [Abstract] [Full Text] [Related]

  • 37. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Anderson RF, Boyd M, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2518-28. PubMed ID: 8691449
    [Abstract] [Full Text] [Related]

  • 38. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.
    Plumb JA, Gerritsen M, Workman P.
    Br J Cancer; 1994 Dec 21; 70(6):1136-43. PubMed ID: 7526885
    [Abstract] [Full Text] [Related]

  • 39. Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells.
    Keyes SR, Loomis R, DiGiovanna MP, Pritsos CA, Rockwell S, Sartorelli AC.
    Cancer Commun; 1991 Dec 21; 3(10-11):351-6. PubMed ID: 1760250
    [Abstract] [Full Text] [Related]

  • 40. Activity of C-7 substituted cyclic acetal derivatives of mitomycin C and porfiromycin against hypoxic and oxygenated EMT6 carcinoma cells in vitro and in vivo.
    Rockwell S, Keyes SR, Loomis R, Kelley M, Vyas DM, Wong H, Doyle TW, Sartorelli AC.
    Cancer Commun; 1991 Jun 21; 3(6):191-8. PubMed ID: 2049227
    [Abstract] [Full Text] [Related]

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