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Journal Abstract Search

126 related items for PubMed ID: 7490724

  • 1. N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity.
    Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GJ, Wardle KA.
    J Med Chem; 1995 Nov 24; 38(24):4760-3. PubMed ID: 7490724
    [No Abstract] [Full Text] [Related]

  • 2. (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.
    Gaster LM, Jennings AJ, Joiner GF, King FD, Mulholland KR, Rahman SK, Starr S, Wyman PA, Wardle KA, Ellis ES.
    J Med Chem; 1993 Dec 10; 36(25):4121-3. PubMed ID: 8258837
    [No Abstract] [Full Text] [Related]

  • 3. Synthesis and pharmacological activity of metabolites of the 5-HT(4) receptor antagonist SB-207266.
    Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G.
    Bioorg Med Chem; 2001 Aug 10; 9(8):2119-28. PubMed ID: 11504648
    [Abstract] [Full Text] [Related]

  • 4. Azabicyclic indole esters as potent 5-HT4 receptor antagonists.
    Wyman PA, Gaster LM, King FD, Sutton JM, Ellis ES, Wardle KA, Young TJ.
    Bioorg Med Chem; 1996 Feb 10; 4(2):255-61. PubMed ID: 8814883
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives.
    Schaus JM, Thompson DC, Bloomquist WE, Susemichel AD, Calligaro DO, Cohen ML.
    J Med Chem; 1998 May 21; 41(11):1943-55. PubMed ID: 9599243
    [Abstract] [Full Text] [Related]

  • 6. 5-HT4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex.
    McLean PG, Coupar IM.
    Naunyn Schmiedebergs Arch Pharmacol; 1995 Aug 21; 352(2):132-40. PubMed ID: 7477435
    [Abstract] [Full Text] [Related]

  • 7. 5-HT3 and 5-HT4 receptors and cholinergic and tachykininergic neurotransmission in the guinea-pig proximal colon.
    Briejer MR, Schuurkes JA.
    Eur J Pharmacol; 1996 Jul 18; 308(2):173-80. PubMed ID: 8840129
    [Abstract] [Full Text] [Related]

  • 8. Effects of 5-HT4 receptor antagonists on rat behaviour in the elevated plus-maze test.
    Silvestre JS, Fernández AG, Palacios JM.
    Eur J Pharmacol; 1996 Aug 15; 309(3):219-22. PubMed ID: 8874143
    [Abstract] [Full Text] [Related]

  • 9. 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.
    Crawforth J, Goodacre S, Maxey R, Bourrain S, Patel S, Marwood R, O'Connor D, Herbert R, Hutson P, Rowley M.
    Bioorg Med Chem Lett; 2000 Dec 18; 10(24):2701-3. PubMed ID: 11133072
    [Abstract] [Full Text] [Related]

  • 10. Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.
    Andersen K, Perregaard J, Arnt J, Nielsen JB, Begtrup M.
    J Med Chem; 1992 Dec 25; 35(26):4823-31. PubMed ID: 1336054
    [Abstract] [Full Text] [Related]

  • 11. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist.
    Hegde SS, Bonhaus DW, Johnson LG, Leung E, Clark RD, Eglen RM.
    Br J Pharmacol; 1995 Jul 25; 115(6):1087-95. PubMed ID: 7582507
    [Abstract] [Full Text] [Related]

  • 12. (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.
    Forbes IT, Dabbs S, Duckworth DM, Jennings AJ, King FD, Lovell PJ, Brown AM, Collin L, Hagan JJ, Middlemiss DN, Riley GJ, Thomas DR, Upton N.
    J Med Chem; 1998 Feb 26; 41(5):655-7. PubMed ID: 9513592
    [No Abstract] [Full Text] [Related]

  • 13. Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
    Bingham S, King BF, Rushant B, Smith MI, Gaster L, Sanger GJ.
    J Pharm Pharmacol; 1995 Mar 26; 47(3):219-22. PubMed ID: 7602484
    [Abstract] [Full Text] [Related]

  • 14. Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.
    Perregaard J, Andersen K, Hyttel J, Sánchez C.
    J Med Chem; 1992 Dec 25; 35(26):4813-22. PubMed ID: 1336053
    [Abstract] [Full Text] [Related]

  • 15. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors.
    Jin JG, Foxx-Orenstein AE, Grider JR.
    J Pharmacol Exp Ther; 1999 Jan 25; 288(1):93-7. PubMed ID: 9862758
    [Abstract] [Full Text] [Related]

  • 16. Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon.
    Irving HR, Tan YY, Tochon-Danguy N, Liu H, Chetty N, Desmond PV, Pouton CW, Coupar IM.
    Life Sci; 2007 Mar 06; 80(13):1198-205. PubMed ID: 17258778
    [Abstract] [Full Text] [Related]

  • 17. The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon.
    Wardle KA, Ellis ES, Baxter GS, Kennett GA, Gaster LM, Sanger GJ.
    Br J Pharmacol; 1994 Jul 06; 112(3):789-94. PubMed ID: 7921604
    [Abstract] [Full Text] [Related]

  • 18. Selective and functional 5-hydroxytryptamine4 receptor antagonism by SB 207266.
    Wardle KA, Bingham S, Ellis ES, Gaster LM, Rushant B, Smith MI, Sanger GJ.
    Br J Pharmacol; 1996 Jun 06; 118(3):665-70. PubMed ID: 8762092
    [Abstract] [Full Text] [Related]

  • 19. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.
    Briejer MR, Bosmans JP, Van Daele P, Jurzak M, Heylen L, Leysen JE, Prins NH, Schuurkes JA.
    Eur J Pharmacol; 2001 Jun 29; 423(1):71-83. PubMed ID: 11438309
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT₆ receptor antagonists.
    Nirogi R, Shinde A, Daulatabad A, Kambhampati R, Gudla P, Shaik M, Gampa M, Balasubramaniam S, Gangadasari P, Reballi V, Badange R, Bojja K, Subramanian R, Bhyrapuneni G, Muddana N, Jayarajan P.
    J Med Chem; 2012 Nov 08; 55(21):9255-69. PubMed ID: 23006002
    [Abstract] [Full Text] [Related]

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