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Journal Abstract Search

164 related items for PubMed ID: 7495480

  • 1. Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.
    Jackman AL, Kimbell R, Brown M, Brunton L, Bisset GM, Bavetsias V, Marsham P, Hughes LR, Boyle FT.
    Anticancer Drug Des; 1995 Oct; 10(7):573-89. PubMed ID: 7495480
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  • 2. Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
    Jackman AL, Kimbell R, Brown M, Brunton L, Boyle FT.
    Anticancer Drug Des; 1995 Oct; 10(7):555-72. PubMed ID: 7495479
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  • 4. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR.
    Cancer Res; 1991 Oct 15; 51(20):5579-86. PubMed ID: 1913676
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  • 12. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B, Pinedo HM, van Hensbergen Y, Smid K, Telleman F, Schoenmakers PS, van der Wilt CL, van Laar JA, Noordhuis P, Jansen G, Peters GJ.
    Clin Cancer Res; 1999 Mar 15; 5(3):643-54. PubMed ID: 10100718
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  • 13. Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.
    Hennequin LF, Boyle FT, Wardleworth JM, Marsham PR, Kimbell R, Jackman AL.
    J Med Chem; 1996 Feb 02; 39(3):695-704. PubMed ID: 8576912
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  • 14. Thymidylate synthase inhibitors.
    Touroutoglou N, Pazdur R.
    Clin Cancer Res; 1996 Feb 02; 2(2):227-43. PubMed ID: 9816165
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  • 15. A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs.
    Sanghani PC, Jackman A, Evans VR, Thornton T, Hughes L, Calvert AH, Moran RG.
    Mol Pharmacol; 1994 Feb 02; 45(2):341-51. PubMed ID: 8114682
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  • 16. The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Jackman AL, Newell DR, Gibson W, Jodrell DI, Taylor GA, Bishop JA, Hughes LR, Calvert AH.
    Biochem Pharmacol; 1991 Oct 24; 42(10):1885-95. PubMed ID: 1741766
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  • 17. Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents.
    Jackman AL, Bisset GM, Jodrell DI, Gibson W, Kimbell R, Bavetsias V, Calvert AH, Harrap KR, Stephens TC, Smith MN.
    Adv Exp Med Biol; 1993 Oct 24; 338():579-84. PubMed ID: 8304184
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  • 19. The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694.
    Jackman AL, Gibson W, Brown M, Kimbell R, Boyle FT.
    Adv Exp Med Biol; 1993 Oct 24; 339():265-76. PubMed ID: 7513935
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  • 20. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 24; 5(9):2548-58. PubMed ID: 10499632
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