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158 related items for PubMed ID: 7499788

  • 1. Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94.
    Chenoufi N, Hubert N, Loréal O, Morel I, Pasdeloup N, Cillard J, Brissot P, Lescoat G.
    J Hepatol; 1995 Aug; 23(2):166-73. PubMed ID: 7499788
    [Abstract] [Full Text] [Related]

  • 2. Iron mobilization, cytoprotection, and inhibition of cell proliferation in normal and transformed rat hepatocyte cultures by the hydroxypyridinone CP411, compared to CP20: a biological and physicochemical study.
    Gaboriau F, Chantrel-Groussard K, Rakba N, Loyer P, Pasdeloup N, Hider RC, Brissot P, Lescoat G.
    Biochem Pharmacol; 2004 Apr 15; 67(8):1479-87. PubMed ID: 15041465
    [Abstract] [Full Text] [Related]

  • 3. Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: comparison of their mechanism of protection with that of desferrioxamine.
    Morel I, Cillard J, Lescoat G, Sergent O, Pasdeloup N, Ocaktan AZ, Abdallah MA, Brissot P, Cillard P.
    Free Radic Biol Med; 1992 Nov 15; 13(5):499-508. PubMed ID: 1334028
    [Abstract] [Full Text] [Related]

  • 4. Cytoprotection and iron mobilization in rat hepatocyte cultures by a new synthetic dihydroxamate chelator.
    Rakba N, Nguyen-Van-Duong MK, Nicolas L, Guillot V, Morel I, Pasdeloup N, Brissot P, Lescoat G.
    Toxicol Lett; 1999 Oct 29; 110(1-2):19-27. PubMed ID: 10593591
    [Abstract] [Full Text] [Related]

  • 5. In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
    Hoyes KP, Jones HM, Abeysinghe RD, Hider RC, Porter JB.
    Exp Hematol; 1993 Jan 29; 21(1):86-92. PubMed ID: 8417963
    [Abstract] [Full Text] [Related]

  • 6. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site.
    Porter JB, Abeysinghe RD, Hoyes KP, Barra C, Huehns ER, Brooks PN, Blackwell MP, Araneta M, Brittenham G, Singh S.
    Br J Haematol; 1993 Sep 29; 85(1):159-68. PubMed ID: 8251385
    [Abstract] [Full Text] [Related]

  • 7. Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones.
    Singh S, Epemolu RO, Dobbin PS, Tilbrook GS, Ellis BL, Damani LA, Hider RC.
    Drug Metab Dispos; 1992 Sep 29; 20(2):256-61. PubMed ID: 1352218
    [Abstract] [Full Text] [Related]

  • 8. EPR study of antioxidant activity of the iron chelators pyoverdin and hydroxypyrid-4-one in iron-loaded hepatocyte culture: comparison with that of desferrioxamine.
    Morel I, Sergent O, Cogrel P, Lescoat G, Pasdeloup N, Brissot P, Cillard P, Cillard J.
    Free Radic Biol Med; 1995 Feb 29; 18(2):303-10. PubMed ID: 7744315
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of iron toxicity in human hepatocyte cultures by pyoverdins Pa A and Pf, the peptidic siderophores of Pseudomonas aeruginosa and fluorescens.
    Jégo P, Chenoufi N, Loréal O, Morel I, Pasdeloup N, Abdallah MA, Brissot P, Lescoat G.
    Liver; 1997 Apr 29; 17(2):70-5. PubMed ID: 9138275
    [Abstract] [Full Text] [Related]

  • 10. Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat.
    Choudhury R, Singh S.
    Drug Metab Dispos; 1995 Mar 29; 23(3):314-20. PubMed ID: 7628295
    [Abstract] [Full Text] [Related]

  • 11. Studies of in vivo iron mobilization by chelators in the ferrocene-loaded rat.
    Florence A, Ward RJ, Peters TJ, Crichton RR.
    Biochem Pharmacol; 1992 Sep 25; 44(6):1023-7. PubMed ID: 1417929
    [Abstract] [Full Text] [Related]

  • 12. Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats.
    Zanninelli G, Choudury R, Loréal O, Guyader D, Lescoat G, Arnaud J, Verna R, Cosson B, Singh S, Hider RC, Brissot P.
    J Hepatol; 1997 Jul 25; 27(1):176-84. PubMed ID: 9252093
    [Abstract] [Full Text] [Related]

  • 13. Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells.
    Chua AC, Ingram HA, Raymond KN, Baker E.
    Eur J Biochem; 2003 Apr 25; 270(8):1689-98. PubMed ID: 12694182
    [Abstract] [Full Text] [Related]

  • 14. Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism.
    Lescoat G, Chantrel-Groussard K, Pasdeloup N, Nick H, Brissot P, Gaboriau F.
    Cell Prolif; 2007 Oct 25; 40(5):755-67. PubMed ID: 17877614
    [Abstract] [Full Text] [Related]

  • 15. The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl-, and 1-[ethan-1'ol]-2-methyl-3-hydroxypyridin-4-one in the rat.
    Fredenburg AM, Sethi RK, Allen DD, Yokel RA.
    Toxicology; 1996 Apr 30; 108(3):191-9. PubMed ID: 8658538
    [Abstract] [Full Text] [Related]

  • 16. Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools.
    Hoyes KP, Porter JB.
    Br J Haematol; 1993 Oct 30; 85(2):393-400. PubMed ID: 8280612
    [Abstract] [Full Text] [Related]

  • 17. Antiproliferative effect of deferiprone on the Hep G2 cell line.
    Chenoufi N, Drénou B, Loréal O, Pigeon C, Brissot P, Lescoat G.
    Biochem Pharmacol; 1998 Aug 15; 56(4):431-7. PubMed ID: 9763218
    [Abstract] [Full Text] [Related]

  • 18. Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.
    Rakba N, Aouad F, Henry C, Caris C, Morel I, Baret P, Pierre JL, Brissot P, Ward RJ, Lescoat G, Crichton RR.
    Biochem Pharmacol; 1998 Jun 01; 55(11):1797-806. PubMed ID: 9714298
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of iron overload toxicity in rat hepatocyte cultures by pyoverdin Pf, the siderophore of Pseudomonas fluorescens.
    Jego P, Hubert N, Morel I, Pasdeloup N, Ocaktan A, Abdallah M, Brissot P, Lescoat G.
    Biochem Pharmacol; 1992 Mar 17; 43(6):1275-80. PubMed ID: 1562281
    [Abstract] [Full Text] [Related]

  • 20. Effects of chelators on iron uptake and release by the brain in the rat.
    Crowe A, Morgan EH.
    Neurochem Res; 1994 Jan 17; 19(1):71-6. PubMed ID: 8139766
    [Abstract] [Full Text] [Related]

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