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806 related items for PubMed ID: 7514264

  • 1. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS, Galivan J, Wright JE, Rosowsky A.
    Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264
    [Abstract] [Full Text] [Related]

  • 2. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
    [Abstract] [Full Text] [Related]

  • 3. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct 15; 48(4):758-65. PubMed ID: 7476904
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A, Wright JE, Vaidya CM, Bader H, Forsch RA, Mota CE, Pardo J, Chen CS, Chen YN.
    J Med Chem; 1998 Dec 17; 41(26):5310-9. PubMed ID: 9857098
    [Abstract] [Full Text] [Related]

  • 5. Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
    Rosowsky A, Vaidya CM, Bader H, Wright JE, Teicher BA.
    J Med Chem; 1997 Jan 31; 40(3):286-99. PubMed ID: 9022795
    [Abstract] [Full Text] [Related]

  • 6. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
    Mauritz R, Peters GJ, Priest DG, Assaraf YG, Drori S, Kathmann I, Noordhuis P, Bunni MA, Rosowsky A, Schornagel JH, Pinedo HM, Jansen G.
    Biochem Pharmacol; 2002 Jan 15; 63(2):105-15. PubMed ID: 11841783
    [Abstract] [Full Text] [Related]

  • 7. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 15; 48(3):459-71. PubMed ID: 7565626
    [Abstract] [Full Text] [Related]

  • 8. Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
    Galivan J, Nimec Z, Rhee M, Boschelli D, Oronsky AL, Kerwar SS.
    Cancer Res; 1988 May 01; 48(9):2421-5. PubMed ID: 2965613
    [Abstract] [Full Text] [Related]

  • 9. Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
    Galivan J, Nimec Z, Rhee M.
    Cancer Res; 1987 Oct 15; 47(20):5256-60. PubMed ID: 2958130
    [Abstract] [Full Text] [Related]

  • 10. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 15; 5(9):2548-58. PubMed ID: 10499632
    [Abstract] [Full Text] [Related]

  • 11. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y, Ohnuma T.
    Mt Sinai J Med; 1992 Oct 15; 59(5):419-24. PubMed ID: 1435841
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
    Rosowsky A, Bader H, Wright JE, Keyomarsi K, Matherly LH.
    J Med Chem; 1994 Jul 08; 37(14):2167-74. PubMed ID: 8035423
    [Abstract] [Full Text] [Related]

  • 13. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
    McGuire JJ, Russell CA, Bolanowska WE, Freitag CM, Jones CS, Kalman TI.
    Cancer Res; 1990 Mar 15; 50(6):1726-31. PubMed ID: 2306727
    [Abstract] [Full Text] [Related]

  • 14. Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues.
    Wright JE, Vaidya CM, Chen Y, Rosowsky A.
    Biochem Pharmacol; 2000 Jul 01; 60(1):41-6. PubMed ID: 10807943
    [Abstract] [Full Text] [Related]

  • 15. Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
    Jansen G, Schornagel JH, Westerhof GR, Rijksen G, Newell DR, Jackman AL.
    Cancer Res; 1990 Dec 01; 50(23):7544-8. PubMed ID: 2253202
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  • 20. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 01; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

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