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Journal Abstract Search

709 related items for PubMed ID: 7529032

  • 1. Enzymatic properties of two mutants of reverse transcriptase of human immunodeficiency virus type 1 (tyrosine 181-->isoleucine and tyrosine 188-->leucine), resistant to nonnucleoside inhibitors.
    Loya S, Bakhanashvili M, Tal R, Hughes SH, Boyer PL, Hizi A.
    AIDS Res Hum Retroviruses; 1994 Aug; 10(8):939-46. PubMed ID: 7529032
    [Abstract] [Full Text] [Related]

  • 2. Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.
    Pelemans H, Aertsen A, Van Laethem K, Vandamme AM, De Clercq E, Pérez-Pérez MJ, San-Félix A, Velázquez S, Camarasa MJ, Balzarini J.
    Virology; 2001 Feb 01; 280(1):97-106. PubMed ID: 11162823
    [Abstract] [Full Text] [Related]

  • 3. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates.
    Ueno T, Shirasaka T, Mitsuya H.
    J Biol Chem; 1995 Oct 06; 270(40):23605-11. PubMed ID: 7559526
    [Abstract] [Full Text] [Related]

  • 4. Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors.
    Auwerx J, Esnouf R, De Clercq E, Balzarini J.
    Mol Pharmacol; 2004 Jan 06; 65(1):244-51. PubMed ID: 14722257
    [Abstract] [Full Text] [Related]

  • 5. Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases.
    Amacker M, Hübscher U.
    J Mol Biol; 1998 May 15; 278(4):757-65. PubMed ID: 9614940
    [Abstract] [Full Text] [Related]

  • 6. Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.
    Pokholok DK, Gudima SO, Yesipov DS, Dobrynin VN, Rechinsky VO, Kochetkov SN.
    FEBS Lett; 1993 Jul 05; 325(3):237-41. PubMed ID: 7686510
    [Abstract] [Full Text] [Related]

  • 7. Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme.
    Tasara T, Amacker M, Hübscher U.
    Biochemistry; 1999 Feb 02; 38(5):1633-42. PubMed ID: 9931031
    [Abstract] [Full Text] [Related]

  • 8. Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
    Maga G, Amacker M, Hübscher U, Gosselin G, Imbach JL, Mathé C, Faraj A, Sommadossi JP, Spadari S.
    Nucleic Acids Res; 1999 Feb 15; 27(4):972-8. PubMed ID: 9927728
    [Abstract] [Full Text] [Related]

  • 9. Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.
    Shaw-Reid CA, Feuston B, Munshi V, Getty K, Krueger J, Hazuda DJ, Parniak MA, Miller MD, Lewis D.
    Biochemistry; 2005 Feb 08; 44(5):1595-606. PubMed ID: 15683243
    [Abstract] [Full Text] [Related]

  • 10. Analysis of HIV-2 RT mutants provides evidence that resistance of HIV-1 RT and HIV-2 RT to nucleoside analogs involves a repositioning of the template-primer.
    Perach M, Rubinek T, Hughes SH, Hizi A.
    J Mol Biol; 1997 May 09; 268(3):648-54. PubMed ID: 9171288
    [Abstract] [Full Text] [Related]

  • 11. [Studies of the resistance of the human immunodeficiency virus to azidothymidine. I. Kinetic studies of the interaction between reverse transcriptase and a series of its mutant forms with substrates and azidothymidine-5'-trisphosphate].
    Pokholok DK, Gudima SO, Esipov DS, Dobrynin VN, Memelova LV, Rechinskiĭ VO, Kochetkov SN.
    Biokhimiia; 1994 May 09; 59(5):739-47. PubMed ID: 7519060
    [Abstract] [Full Text] [Related]

  • 12. Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli.
    Kim B, Hathaway TR, Loeb LA.
    J Biol Chem; 1996 Mar 01; 271(9):4872-8. PubMed ID: 8617758
    [Abstract] [Full Text] [Related]

  • 13. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.
    Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, Pauwels R, Andries K, Janssen PA, Arnold E.
    J Mol Biol; 1994 Oct 28; 243(3):369-87. PubMed ID: 7525966
    [Abstract] [Full Text] [Related]

  • 14. Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
    Buckheit RW, Fliakas-Boltz V, Yeagy-Bargo S, Weislow O, Mayers DL, Boyer PL, Hughes SH, Pan BC, Chu SH, Bader JP.
    Virology; 1995 Jun 20; 210(1):186-93. PubMed ID: 7540784
    [Abstract] [Full Text] [Related]

  • 15. The catalytic properties of the reverse transcriptase of the lentivirus equine infectious anemia virus.
    Rubinek T, Loya S, Shaharabany M, Hughes SH, Clark PK, Hizi A.
    Eur J Biochem; 1994 Feb 01; 219(3):977-83. PubMed ID: 7509281
    [Abstract] [Full Text] [Related]

  • 16. A drug resistance mutation in the inhibitor binding pocket of human immunodeficiency virus type 1 reverse transcriptase impairs DNA synthesis and RNA degradation.
    Fan N, Rank KB, Slade DE, Poppe SM, Evans DB, Kopta LA, Olmsted RA, Thomas RC, Tarpley WG, Sharma SK.
    Biochemistry; 1996 Jul 30; 35(30):9737-45. PubMed ID: 8703945
    [Abstract] [Full Text] [Related]

  • 17. Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors.
    Debyser Z, De Vreese K, Knops-Gerrits PP, Baekelandt V, Bhikhabhai R, Strandberg B, Pauwels R, Anné J, Desmyter J, De Clercq E.
    Mol Pharmacol; 1993 Apr 30; 43(4):521-6. PubMed ID: 7682649
    [Abstract] [Full Text] [Related]

  • 18. A rapid phenotypic assay for detecting multiple nucleoside analogue reverse transcriptase inhibitor-resistant HIV-1 in plasma.
    Qari SH, Winters M, Vandamme AM, Merigan T, Heneine W.
    Antivir Ther; 2002 Jun 30; 7(2):131-9. PubMed ID: 12212925
    [Abstract] [Full Text] [Related]

  • 19. Enzymatic properties and sensitivity to inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with Glu-138-->Arg and Tyr-188-->His mutations.
    Zhang H, Vrang L, Bäckbro K, Unge T, Noréen R, Oberg B.
    Antiviral Res; 1994 May 30; 24(1):43-57. PubMed ID: 7524439
    [Abstract] [Full Text] [Related]

  • 20. Construction of the chimeric reverse transcriptase of simian immunodeficiency virus sensitive to nonnucleoside reverse transcriptase inhibitor.
    Isaka Y, Sato A, Kawauchi S, Suyama A, Miki S, Hayami M, Fujiwara T.
    Microbiol Immunol; 1998 May 30; 42(3):195-202. PubMed ID: 9570285
    [Abstract] [Full Text] [Related]

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