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Journal Abstract Search

263 related items for PubMed ID: 7530622

  • 1. The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans.
    Rodrigues AD, Ferrero JL, Amann MT, Rotert GA, Cepa SP, Surber BW, Machinist JM, Tich NR, Sullivan JP, Garvey DS.
    Drug Metab Dispos; 1994; 22(5):788-98. PubMed ID: 7530622
    [Abstract] [Full Text] [Related]

  • 2. In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.
    Rodrigues AD, Kukulka MJ, Ferrero JL, Cashman JR.
    Drug Metab Dispos; 1995 Oct; 23(10):1143-52. PubMed ID: 8654204
    [Abstract] [Full Text] [Related]

  • 3. Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey.
    Sharer JE, Shipley LA, Vandenbranden MR, Binkley SN, Wrighton SA.
    Drug Metab Dispos; 1995 Nov; 23(11):1231-41. PubMed ID: 8591724
    [Abstract] [Full Text] [Related]

  • 4. The role of cytochromes P-450 and flavin-containing monooxygenase in the metabolism of (S)-nicotine by rabbit lung.
    Williams DE, Shigenaga MK, Castagnoli N.
    Drug Metab Dispos; 1990 Nov; 18(4):418-28. PubMed ID: 1976062
    [Abstract] [Full Text] [Related]

  • 5. In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.
    Kumar GN, Jayanti V, Lee RD, Whittern DN, Uchic J, Thomas S, Johnson P, Grabowski B, Sham H, Betebenner D, Kempf DJ, Denissen JF.
    Drug Metab Dispos; 1999 Jan; 27(1):86-91. PubMed ID: 9884314
    [Abstract] [Full Text] [Related]

  • 6. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
    Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, Hughes ML, Cadman ED, Adams P, Garvey DS.
    J Pharmacol Exp Ther; 1994 Jul; 270(1):310-8. PubMed ID: 7518514
    [Abstract] [Full Text] [Related]

  • 7. Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices.
    Steensma A, Beamand JA, Walters DG, Price RJ, Lake BG.
    Xenobiotica; 1994 Sep; 24(9):893-907. PubMed ID: 7810171
    [Abstract] [Full Text] [Related]

  • 8. Comparative studies of the in vitro metabolism and covalent binding of 14C-benzene by liver slices and microsomal fraction of mouse, rat, and human.
    Brodfuehrer JI, Chapman DE, Wilke TJ, Powis G.
    Drug Metab Dispos; 1990 Sep; 18(1):20-7. PubMed ID: 1970773
    [Abstract] [Full Text] [Related]

  • 9. Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase.
    Acheampong AA, Chien DS, Lam S, Vekich S, Breau A, Usansky J, Harcourt D, Munk SA, Nguyen H, Garst M, Tang-Liu D.
    Xenobiotica; 1996 Oct; 26(10):1035-55. PubMed ID: 8905918
    [Abstract] [Full Text] [Related]

  • 10. Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.
    Onderwater RC, Commandeur JN, Vermeulen NP.
    Toxicology; 2004 Apr 15; 197(2):81-91. PubMed ID: 15003319
    [Abstract] [Full Text] [Related]

  • 11. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov 15; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 12. Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices.
    Ekins S, Williams JA, Murray GI, Burke MD, Marchant NC, Engeset J, Hawksworth GM.
    Drug Metab Dispos; 1996 Sep 15; 24(9):990-5. PubMed ID: 8886609
    [Abstract] [Full Text] [Related]

  • 13. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
    Beland FA.
    Toxic Rep Ser; 1999 Aug 15; (59):1-66, A1-E7. PubMed ID: 11803702
    [Abstract] [Full Text] [Related]

  • 14. Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.
    Lin JH, Chiba M, Balani SK, Chen IW, Kwei GY, Vastag KJ, Nishime JA.
    Drug Metab Dispos; 1996 Oct 15; 24(10):1111-20. PubMed ID: 8894513
    [Abstract] [Full Text] [Related]

  • 15. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
    Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP.
    J Pharmacol Exp Ther; 1994 Oct 15; 271(1):353-61. PubMed ID: 7965735
    [Abstract] [Full Text] [Related]

  • 16. Biotransformation of a somatostatin analogue in precision-cut liver and kidney slices from rat, dog and man.
    Connors MS, Larrauri A, Dannecker R, Nufer R, Brendel K, Vickers AE.
    Xenobiotica; 1996 Feb 15; 26(2):133-41. PubMed ID: 8867998
    [Abstract] [Full Text] [Related]

  • 17. Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human.
    Prueksaritanont T, Balani SK, Dwyer LM, Ellis JD, Kauffman LR, Varga SL, Pitzenberger SM, Theoharides AD.
    Drug Metab Dispos; 1995 Jul 15; 23(7):688-95. PubMed ID: 7587955
    [Abstract] [Full Text] [Related]

  • 18. Characterization of [3H]ABT-418: a novel cholinergic channel ligand.
    Anderson DJ, Williams M, Pauly JR, Raszkiewicz JL, Campbell JE, Rotert G, Surber B, Thomas SB, Wasicak J, Arneric SP.
    J Pharmacol Exp Ther; 1995 Jun 15; 273(3):1434-41. PubMed ID: 7791118
    [Abstract] [Full Text] [Related]

  • 19. In vitro metabolism of a potent HIV-protease inhibitor (141W94) using rat, monkey and human liver S9.
    Singh R, Chang SY, Taylor LC.
    Rapid Commun Mass Spectrom; 1996 Jun 15; 10(9):1019-26. PubMed ID: 8755234
    [Abstract] [Full Text] [Related]

  • 20. Flavin-containing monooxygenase-mediated N-oxidation of the M(1)-muscarinic agonist xanomeline.
    Ring BJ, Wrighton SA, Aldridge SL, Hansen K, Haehner B, Shipley LA.
    Drug Metab Dispos; 1999 Oct 15; 27(10):1099-103. PubMed ID: 10497134
    [Abstract] [Full Text] [Related]

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