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Journal Abstract Search

181 related items for PubMed ID: 7544273

  • 1. Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance.
    Joshi L, Murata Y, Wondisford FE, Szkudlinski MW, Desai R, Weintraub BD.
    Endocrinology; 1995 Sep; 136(9):3839-48. PubMed ID: 7544273
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  • 2. Fusing the carboxy-terminal peptide of the chorionic gonadotropin (CG) beta-subunit to the common alpha-subunit: retention of O-linked glycosylation and enhanced in vivo bioactivity of chimeric human CG.
    Furuhashi M, Shikone T, Fares FA, Sugahara T, Hsueh AJ, Boime I.
    Mol Endocrinol; 1995 Jan; 9(1):54-63. PubMed ID: 7539107
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  • 3. Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity.
    Szkudlinski MW, Thotakura NR, Bucci I, Joshi LR, Tsai A, East-Palmer J, Shiloach J, Weintraub BD.
    Endocrinology; 1993 Oct; 133(4):1490-503. PubMed ID: 8404588
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  • 4. Biological activity and metabolic clearance of a recombinant human thyrotropin produced in Chinese hamster ovary cells.
    Thotakura NR, Desai RK, Bates LG, Cole ES, Pratt BM, Weintraub BD.
    Endocrinology; 1991 Jan; 128(1):341-8. PubMed ID: 1846103
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  • 5. Carbohydrate modifications transform human chorionic gonadotropin into a potent stimulator of adenosine 3',5'-monophosphate and growth responses in FRTL-5 thyroid cells.
    Hoermann R, Keutmann HT, Amir SM.
    Endocrinology; 1991 Feb; 128(2):1129-35. PubMed ID: 1846577
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  • 8. Development of a long-acting erythropoietin by fusing the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit to the coding sequence of human erythropoietin.
    Fares F, Ganem S, Hajouj T, Agai E.
    Endocrinology; 2007 Oct; 148(10):5081-7. PubMed ID: 17641000
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  • 9. Expression of human thyrotropin in cell lines with different glycosylation patterns combined with mutagenesis of specific glycosylation sites. Characterization of a novel role for the oligosaccharides in the in vitro and in vivo bioactivity.
    Grossmann M, Szkudlinski MW, Tropea JE, Bishop LA, Thotakura NR, Schofield PR, Weintraub BD.
    J Biol Chem; 1995 Dec 08; 270(49):29378-85. PubMed ID: 7493973
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  • 12. Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin.
    Grossmann M, Szkudlinski MW, Dias JA, Xia H, Wong R, Puett D, Weintraub BD.
    Mol Endocrinol; 1996 Jun 08; 10(6):769-79. PubMed ID: 8776737
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  • 13. Subunit-specific functions of N-linked oligosaccharides in human thyrotropin: role of terminal residues of alpha- and beta-subunit oligosaccharides in metabolic clearance and bioactivity.
    Szkudlinski MW, Thotakura NR, Weintraub BD.
    Proc Natl Acad Sci U S A; 1995 Sep 26; 92(20):9062-6. PubMed ID: 7568073
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  • 14. Design of a long-lived thyrotropin antagonist from derivatives of human chorionic gonadotropin.
    Hoermann R, Amir SM, Nomura T, Ingbar SH.
    Endocrinology; 1989 Jan 26; 124(1):223-32. PubMed ID: 2462487
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  • 15. The role of the asparagine-linked oligosaccharides of the alpha-subunit in human thyrotropin bioactivity.
    Fares FA, Gruener N, Kraiem Z.
    Endocrinology; 1996 Feb 26; 137(2):555-60. PubMed ID: 8593802
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  • 16. Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit.
    Fares FA, Suganuma N, Nishimori K, LaPolt PS, Hsueh AJ, Boime I.
    Proc Natl Acad Sci U S A; 1992 May 15; 89(10):4304-8. PubMed ID: 1374895
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  • 17. Conversion of thyrotropin heterodimer to a biologically active single-chain.
    Fares FA, Yamabe S, Ben-Menahem D, Pixley M, Hsueh AJ, Boime I.
    Endocrinology; 1998 May 15; 139(5):2459-64. PubMed ID: 9564858
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  • 18. Carbohydrate-mediated polyethylene glycol conjugation of TSH improves its pharmacological properties.
    Park A, Honey DM, Hou L, Bird JJ, Zarazinski C, Searles M, Braithwaite C, Kingsbury JS, Kyazike J, Culm-Merdek K, Greene B, Stefano JE, Qiu H, McPherson JM, Pan CQ.
    Endocrinology; 2013 Mar 15; 154(3):1373-83. PubMed ID: 23389953
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  • 20. Asparagine-linked oligosaccharide structures determine clearance and organ distribution of pituitary and recombinant thyrotropin.
    Szkudlinski MW, Thotakura NR, Tropea JE, Grossmann M, Weintraub BD.
    Endocrinology; 1995 Aug 15; 136(8):3325-30. PubMed ID: 7628367
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